FDA inopa nyevero pamusoro pechirwere chisingawanzo asi chakakomba
Lamictal (lamotrigine) mushonga unticonvulsive unowanzoshandiswa sechimiro chetsika kune vanhu vanorarama neBipolar disorder . Inoshanda kuburikidza nekuenzanisa kusiyanisa kwakanyanya mumafungiro uye kunonyanya kubatsira mukurapa kuora mwoyo kwakanyanya. Mishonga yave ichinakidzwa kushandiswa kwepamusoro kubva pakutanga kwayo muna 1994 uye nhasi iri pakati peHorld Health Organisation's List of Essential Medications.
Asi, pasinei nemararamiro ayo akatendwa, Lamictal ine dambudziko rayo. Mune vamwe vanhu, Lamictal yave ichizivikanwa ichikonzera kupisa kwakanyanya uye kuputika, kutsvaga kwakatungamirira US Food and Drug Administration (FDA) kubudisa nyevero bhenekeri nyevero kuvayiridzira vatengi pamusoro pechinhu chisingawanzo asi chinogona kuuraya.
Lamictal uye Hypersensitivity Reactions
Mune mazano avo, FDA yakanyevera pamusoro pehuwandu hwehutachiona hwehutano hunogona kuitika kuvanhu vanotora Lamictal. A hypersensitive reaction ndiyo imwe iyo iyo mamiriro kana mishonga inokonzera kuti maitiro ezvirwere zvemusununguko awedzere kugadzirisa, zvichikonzera kurwara kana kutadza kushandura mafungiro ega.
NaRamictal, izvi zvinogona kusanganisira kushandurwa kunozivikanwa seStevens-Johnson syndrome (SJS), chepidermal necrolysis (TEN), uye zvinodhaka zvinoshandiswa nemishonga ne eosinophilia uye systemic zviratidzo (DRESS syndrome).
Chimwe nechimwe chezviitiko izvi chinoratidzika nechakaoma (vamwe vanoti "kutsamwa") kumhanyira izvo zvinowanzoitika mavhiki maviri kusvika masere ekushandisa zvinodhaka.
Kufa kwehuwandu hunokosha, kubva pa5 kubva muzana kuenda kune yakakwirira se30 muzana.
Chimwe nechimwe chinogadziriswa chinotsanangurwa nezvayo zvinowanikwa:
- Stevens-Johnson Syndrome (SJS) inogona kutotanga kufanana nemararamiro akafanana nehupukanana semusoro, fever, chironda, kukwezva, chirwere, uye kurutsa. Izvi zvinogona kuteverwa nehupenyu hwose hunoonekwa nekukurumidza kukurumidza kupararira, kuputika kwechiso uye rurimi, uye kuputika kwakanyanya kwemakumbo emuromo, mhuno, uye maziso. Kushanda kweganda kunogona kuva kunetseka kunoshamisa uye, pane dzimwe nguva, kunotungamirira kumusasa nekudururwa kweganda.
- Dhiyabhorosi epidermal necrolysis (TEN) inokosha SJS asi yakaipisisa. DZENYU inotsanangurwa sechisimba chezvinopfuura 30 muzana zveganda zvakasiyana neSJS iyo inosanganisira zvishoma pane 10 muzana. Uyezve, mukana wekufa kubva kuTEN uri pakati pechina kana katatu mukuru kune SJS.
- DRESS syndrome inoshandiswa nemishonga inogona kukonzera kukwikwidzana pamwe nemamwe zviratidzo zvinosanganisira kusuruvara kunetseka uye kuputika kwechikamu chimwechete chikuru (kazhinji kacho chiropa, mafungiro, mapapu, mwoyo, musumuka, kana pancreas).
Kurapa kunosanganisira kupedzisira kuitika kweLamictal uye kushandiswa kwemishonga inotsigira kurapa marwadzo, kudzivirira utachiona, uye kuvimbisa kuti munhu wacho anoramba akachengetwa zvakanaka. Kuora kweganda kunobatwa nenzira yakafanana kune moto unopisa. Corticosteroids inowanzoshandiswa kuderedza kupisa.
Zviitiko Zvinosangana neHypersensitivity
Kakawanda, vanhu vanopfuura pasi pe17 vane mikana yekudavira kuna Lamictal kupfuura vanhu vakuru. Mukuwedzera, pane zvinhu zvakawanda zvinogona kuwedzera mukana wekupindura kwakashata:
- Kutora zvinopfuura chirongwa chinorayirwa paunotanga kurapwa
- Kuwedzeresa chiremba nokukurumidza paunotanga panzvimbo pokutsika zvishoma nezvishoma
- Kuchengetedza kurapwa uye kutanga zvakare pane zvakakwana zvizere
- Kutora mishonga Depakene (valproic acid) kana Depakote (sodium valproate) pamwe chete naLamictal
Inofanira kurehwa, zvisinei, kuti hypersensitivity inogona kuitika dzimwe nguva kunyange iwe uri kutora mishonga sezvinorayirwa. Kunyange zvazvo maitiro ezviratidzo anoita seanoita chikamu, zvikonzero zvinowanzoita idiopathic (zvinoreva kuti hatizivi chete chikonzero).
Zvinorayirwa neBlack Box Warning
IA FDA yakabudisa nyevero yebhokisi yepamusoro nekuda kwehuwandu hwehutano hwehutachiona hunofananidzwa nemimwe mishonga inoshandiswa kugadzirisa zvirwere zvepfungwa.
Maererano nekutsvakurudza kwavo, pane hutatu huwandu huri muhutano kana iwe ukatora Lamictal uchienzanisa nedzimwe mamiriro ekugadzirisa.
Kana uri pasi pemakore gumi nematanhatu, dambudziko racho richawedzera kaviri. Zvakakosha kucherechedza, zvisinei, kuti havasi zvose zvinokonzerwa ne hypersensitivity zvichaguma neSJS. Kuzviisa zvose muone, pane chaizvoizvo 0.1 muzana mukana wechiitiko ichocho chinoitika. Pakupedzisira, kwaiva kuoma kwezvaiitika, pamwe nekuwanikwa kweimwe mafungiro ekusimudzira zvinodhaka, izvo zvakagadzirisa chisarudzo cheDFA zvakanyanya sekuwanda kwehuwandu hwega.
Chinhu chakakosha ndeichi: Kana uchinge uchinge uchinge uchatora Lamictal, ona chiremba wako pakarepo. Kana iri kupararira nokukurumidza, danai 911 kana kuenda kunzvimbo yako yepamhanho yekukurumidza. Zviri nani kuti uve wakachengeteka kudarika urombo, zvisinei nokuti njodzi inogona kuva yakaderera.
> Sources:
> GlaxoSmithKline. " Lamictal (lamotrigine) : Pfungwa Dzokunyora Mashoko" Triangle Park, North Carolina; yakarongedzwa muna December 2016.
> Wang, X .; Iv, B ;; Wang, H ;; et al. "Lamotrigine-yakakonzera zvakanyanya kukanganiswa kwemaitiro akashata: Ongorora zvinyorwa kubva muna 1999-2014." Zvinyorwa zveKliniki Neuroscience. 2015; 22 (6): 1005-1011.