The Scarce Science Inopera Ichi Calcium Channel Blocker
Verapamil, chimiro che calcium channel blocker, yakadzidzwa makore akapfuura sechirwere chezvikamu zvemanic muvanhu vane bipolar disorder. Izvozvo zvichiti, svesa dhesi shure kwacho inoshaya uye inopesana, zvinoreva kuti zvimwe zvidzidzo zvakawana rubatsiro uye vamwe havana. Pasinei, haisi iyo inofanirwa kana yemishonga yakashandiswa inoshandiswa nevarapi vezvepfungwa mukurapa bipolar disorder .
Ngationgororei nhoroondo yesayenzi mushure mekushandisa verapamil uye dzimwe calcium channel blockers mu bipolar disorder.
Chii chinonzi Calcium Channel Blockers?
Calcium channel blockers inoshandisa kufamba kwe calcium mumasero emwoyo uye midzi yeropa, kufara mumidziyo yeropa uye kuwedzerwa kugoverwa kweropa uye oksijeni kumwoyo. Iyo inowanzoshandiswa kurapa kukwirira kweropa, arrhythmia (kusagadzikana kwepfungwa) uye angina pectoris (kurwadziwa kwepamu-yakabatana nemwoyo).
Iyo yakakura calcium channel inogadzirisa maitiro ayo akaongororwa seanokwanisa kurapwa kwebipolar disorder, kunyanya ne manic episodes inosanganisira:
- Verapamil - mazita mazita Calan, Isoptin SR
- Nimodipine - zita rainzi Nimotop
- Diltiazem - zita reCardizem, Cartia XT, Dilacor XR, Tiazac
Verapamil
Nezvekugona kunobatsira, rimwe ra2002 kuongorora muBiological Psychiatry rakarongedza vakadzi vane 11 vane mania kana vakavhengana zviratidzo zvekuora mwoyo uye mania.
Pakati pavakadzi vane gumi nemana gumi nemana, 9 vavo vakaratidza kupindurwa kwakanaka kana kuvandudzwa mumutambo wavo mushure mokunge vatapwa ne verapamil.
Mune chidzidzo che2008 muBipolar Disorders, verapamil ndoga hauna kuvandudza mapepa evanhu, asi kana ichibatanidzwa ne lithiamu, yakaita. Izvo zvataurwa, chidzidzo chacho chakanga chichiri chiduku, uye vane varwere gumi chete vanotora kuwirirana kwe verapamil uye lithium.
Munyori akacherechedza zvakare kuti chero munhu anotora mutambo we verapamil uye lithiamu inoda kuongororwa zvakadzama, sezvo pane chiitiko chekukanganisa kwakakomba kwakafanana:
- Kuwedzera kweiyo lithium side effects
- choreoathetosis - kusununguka kusununguka
- slow heart rate kana zvichida kushaya mwoyo
- matambudziko nekubatana
Nimodipine
Chimwe che2002 chidzidzo chemuAmerican Journal of Obstetrics uye Gynecology rakashuma pamusoro pekubudirira kweiimodipine mune mukadzi waiva nepamuviri. Akange asingakwanisi kubvumira chimwe chimiro chechimiro chetsika, lithium.
Uyewo, maererano nekudzidza kwekare muBipolar Disorders , nimodipine inogona kubatsira kuvanhu vane bipolar disorder vasingateereri kumishonga yemagariro, kunyanya avo vane--kurumidza-mabhasikoro uye zvishoma zvekare zvinodzvinyirira zvikamu.
Diltiazem
Mune zvishoma zvidzidzo zvema 2000 muna Journal of Psychiatry neNeuroscience, yevatwere vasere vane chirwere chinopesana neBipolar disorder, pakanga paine kuderera kwezvose manic uye kuora mwoyo mapepa mushure mekutora diltiazem. Izvo zvichiti, pane dzimwe matambudziko pamwe nekugadzirwa kwechidzidzo. Somuenzaniso, varwere vakanga vachitora mamwe mishonga kunze kwe diltiazem, uye yakanga iri duku.
Izvi Zvose Zvinorevei?
Zvakakosha kunzwisisa kuti calcium channel blockers haisi miviri yemishonga yekuita mania - sekuratidzwa kwekuti pane zvidzidzo zvishomanana pamusoro pavo.
Nezvo, hazvina kunyatsojeka panguva ino izvo basa remangwana re calcium channel blockers richava mukurapa mania ye bipolar disorder. Zvinogona kunge zvinoshandiswa pamwe chete nemamwe mafungiro emamiriro ezvinhu kana munhu asingateereri kugadzikana kwemamiriro ega kana kuti kumwe kusanganisa kwemishonga.
Sources:
Dubovsky SL, Franks RD, Allen S, & Murphy J. Psychiatry Res. 1986 Aug; 18 (4): 309-20.
Goodnick PJ Kushandiswa kweiimodipine mukurapa kwezvinetso zvepfungwa. Bipolar Disord. 2000 Sep; 2 (3 Pt 1): 165-73.
Mallinger AG et al. Verapamil augmentatin yemiti inonzi lithiamu inogadzirisa zvinowanikwa mu mania isingateereri ku lithium chete: kutanga kwekuwana uye kukurukurirana nzira dzekurapa. Bipolar Disord . 2008 Dec; 10 (8): 856-66.
Silverstone PH & L. Birkett. Diltiazem sokurapa kwekuwedzera mune varwere vane kurapa kusinganzwisisiki bipolar disorder: a retrospective study. J Psychiatry Neurosci. 2000 May; 25 (3): 276-80.
Wisner KL et al. Verapamil kurapa kwevakadzi vane bipolar disorder. Biol Psychiatry. 2002 May 1; 51 (9): 745-52.
Yingling DR, Utter G, Vengalil S, & Mason B. Calcium channel blocker, nimodipine, pakurapa bipolar disorder panguva yekudzivirira. Am J Obstet Gynecol . 2002 Dec; 187 (6): 1711-2.