Cocaine ine mishonga yemwoyo yakawanda. Hapana chimwe chazvo chakanaka.
Kune zvinhu zvishomanana zvipatara vanachiremba vanovhunduka pane kungoona mudiki wekodineine anoratidza kurwadziwa kwepfupa, kana zvimwe zviratidzo zvinoratidza hutano hwepfungwa. Kutya kwavo kwakanyatsotsika.
Zvakashata kuti mudiki uyu, munhu akasiyana-ane hutano angave ari kutambura nehutachiona-hutsva hunotyisa hupenyu kana hutachiona-hunoita hutano hwehutano.
Chimwe chinowedzera kuipa ndechokuti chiremba anoziva kuti kugadzira chirwere chakarurama kunogona kunge kwakaoma uye kunodhura (sezvo cocaine inogona kukonzera matambudziko akawanda emwoyo).
Kunyanya kunetseka, kana chirwere chinonyatsokonzerwa, chirwere chinogona kunge chakanyanya kuoma, nemhaka yemigumisiro yakawanda yekodineine mumuviri wepanyama. Uyezve, iyo chirwere chechidiki kwenguva refu chinogona kunge chichigadzirisa, kunyange kana chirwere chakarurama chichiitwa nokukurumidza, uye kurapwa kunotangwa pakarepo.
Kocaine Inobatsira Sei Mwoyo Mwoyo?
Cocaine imishonga inobvisa reuptake ye norepinephrine mumakurendi. Izvi zvinoita kuti norepinephrine igare yakashanda kwenguva yakareba, zvichiita kuti simba iri rive neurotransmitter rine simba mukati mehutano hwemutsitsi. Iko kunokanganisa kunzwira tsitsi kwebasa kwakave nemigumisiro yakawanda pamwoyo yemavhu.
Inonyanya kuwedzera simba remitsipa yemwoyo sezvinobvumirana, uye panguva imwechete iyo inosimudzira kushaya mwoyo uye kuwedzera kweropa. Zvinhu izvi zvose zvinowedzera basa remwoyo, uye naizvozvo kuda kwemoyo kune oxygen nemuviri.
Asi panguva imwechete iyo inokonzera mhepo yehutano kushanda zvakaoma zvikuru, cocaine inokonzerawo constriction ye capillaries, kuderedza kubuda kweropa kusvika pamwoyo wemisungo.
Mukuwedzera, cocaine inokurudzira ropa kuvhara mukati memidziyo yeropa.
Uku kukanganiswa kwakaipa kwemigumisiro. Kunyange zvazvo ichichiwedzera kuwedzera kwechido chemoyo we oxygen, cocaine panguva imwechete inorega ropa richiyerera kusvika pamwoyo wemisungo, zvichidzivirira huwandu hwemhepo yakakwanisa kununurwa. Mwoyo yemavhudhi saka inowedzera kuomeswa.
Ndezvipi Zvirwere Zvemwoyo Zvinokonzerwa neCroatiaine?
Zvimwe zvinokosha zvepfungwa dzemwoyo zvinogona kukonzerwa nekubatanidzwa kwemigumisiro inokonzerwa nekushandiswa kwecocaine.
Izvi zvinosanganisira:
- Myocardial infarction (kurwisa mwoyo). Kutambudza mwoyo ndechimwe chinhu chinonyanya kuzivikanwa chekushandisa kwecocaine, uye chinogona kuitika nemuipi wekhocaine, uye kunyange munguva yekutanga vashandisi. Yakawanda yekodineine-inokonzerwa nemwoyo inorwisa inowanikwa mukati meawa imwe yekushandisa chirwere ichi, uye iyo inonyanyove yakawanda vaduku. Kutaura zvazviri, kushandisa kocaine kwave kwakabatanidzwa mune zvinenge makumi maviri ne25 zvekurwadziwa kwemoyo zvinowanikwa kune vanhu vanopfuura 45. Verenga pamusoro pekurapa kwemyocardial infarction.
- Aortic dissection. Kugadzikana kwakanyanya kweaortic - kusvetuka kamwe kamwe kworusvingo rwe-aorta - chinhu chinorwadza zvikuru uye chinotyisa upenyu. Kunyange zvazvo pane zvikonzero zvakawanda zveaortic dissection, muvanhu vaduku cocaine vanoshandisa chikonzero chakawanda.
- Coronary artery aneurysm. Irooriary artery aneurysms, ibhoti-kufanana nekudengenyeka kwemaketari emakoroni, inowanzoshandiswa mumashandisi ecocaine, inoitika kusvika kusvika 30% evashandi vasingaperi. Ikorea yerinoni aneurysms inokonzera kushaya mwoyo.
- Myocarditis uye cardiomyopathy. Cocaine inokonzera myocarditis, kana kuputika kwemutsipa wemwoyo. Myocarditis inogona kutungamirira kukuvadza kwemutsipa wemwoyo, kana chirwere chemwoyo. Somugumisiro, kukanganisa kwemwoyo kunogona kuitika.
- Mwoyo rhythm zvinetso. Kushandiswa kweCocaine kunogona kukonzera maitiro akawanda emwoyo. Mukuwedzera pakukonzera kufa kamwe-kamwe kubva kune-ventricular fibrillation, cocaine inogonawo kubudisa bundle branch block, heart block, torsades de pointes, uye marudzi akawanda epamusoro-soro tachycardias.
- Stroke. Ngozi yekurohwa pakati pevashandisi veCocaine inofungidzirwa kuti inosvika kanomwe pane yakakwirira iyo ndeye vasiri vashandisi.
Nei Klaineine Shandisa Kushandura Kurapa Kwemwoyo Matambudziko
Kazhinji, kurapwa kwemakemikari ecocaine-induced cardiovascular kufanana nekurapa kwezvinetso zvechimiroa iyo apo kushandisa cocaine hakusi chinhu. Zvisinei, cocaine inoshandisa kurapa kwakaoma mune dzimwe nzira dzinokosha:
- Beta blockers haafaniri kushandiswa nevarwere vachitora cocaine. Beta blockers inonyanya kukosha pakuchengetedzwa kwechironi chirwere chetachiona, kurwisa kwemwoyo, angina, uye mwoyo kusagadzikana. Zvisinei, kune vanhu vakatora cocaine, beta blockers (iyo inokonzera beta-tsitsi nemigumisiro ye norepinephrine) "zizarurire" alpha-tsitsi zvinoshungurudza, zvichiita kuti kuwedzere kudarika kwemasero maduku, nekuwedzerwa kweropa. Ichokwadi ichi chinotora chirwere chakakosha kunze kwechirwere chemaoko pavanenge vachitarisana nechirwere chemwoyo.
- Kana uchitarisa izvo zvinoratidzika sekurwadza kwepfungwa, kushandiswa kwemishonga ye-clot-busting - zvinodhaka zvinogadzira fibrinolysis - hazvifanirwi kushandiswa mumushandisi wekodine usina kutanga kuita catheterization yemwoyo. Izvi ndezvokuti kuchinja kweEGG kunowanzoonesa kuti kushaya mwoyo kwakanyanya kuri kuitika kunogona kuonekwa mumashandisi e cocaine avo vari kunyangwe vasina chirwere chemwoyo.
- Vanachiremba vanotya kushandisa stents kuti vabate chirwere chegoniyria chirwere mumashandisi e cocaine, nokuti stent thrombosis (kubvisa kubva kune stent) yakakwirira kwazvo kuvanhu ava.
Shoko Rinobva
Kushandiswa kwecocaine kunogona kuisa kukanganisa kwakanyanya pamwoyo uye maitiro epascular, uye kunogona kutungamirira kune zvakasiyana-siyana zvinokonzerwa nemwoyo. Uyezve, pamusana pemigumisiro yekodineine pamusoro pehutano hwevanhu, kusarudzwa kwekurapa kunongopedzisira kune vanhu vane cocaine-yakakonzera matambudziko emwoyo.
> Sources:
> Afonso L, Mohammad T, Thatai D. Crack Whips the Heart: Review of Cardiovascular Toxicity of Cocaine. Am J Cardiol 2007; 100: 1040.
> Maraj S, Figueredo VM, Lynn Morris D. Cocaine uye Moyo. Clin Cardiol 2010; 33: 264.
> McCord J, Jneid H, Hollander JE ne et al. Mutungamiri weCocaine-Associated Chest Pain uye Myocardial Infarction: Scientific Statement kubva kuAmerican Heart Association Acute Cardiac Care Committee yeChristian on Clinical Cardiology. Circulation 2008; 117: 1897.
> Schwartz BG, Rezkalla S, Kloner RA. Mwoyo Muchiratidzo cheKlaineine. Circulation 2010; 122: 2558.