Kutsvaga Kunogona Kurondedzera Kudzokera Kwechisimba
Vashandisi venguva yakareba yekocaine vanogona kurasika zvimwe zvekugona kwavo kubata nepamusoro nekuyeuka kunyange zvinhu zvisiri nyore uye vanogona kuita sarudzo dzavo dzekuita zvisakundikana, maererano neongororo yeMRI yebongo rea cocaine vanoshungurudza.
Kushandiswa zvisina kukodzera kwekodhaini yakakanganiswa zvakananga nekushaya simba munzvimbo dzeuropi dzakabatanidzwa mukufunga kwakakwirira nekuita zvisarudzo. Vatsvakurudzi vanotaura kuti kukanganisa kunokonzerwa nekufungidzira kunogona kubatsira kutsanangura kuti nei cocaine vashandisi vanopfuurira mukushandisa mushonga kana kudzoka kwairi mushure mekusiya nguva.
Chidzidzo chacho chaitungamirirwa naDkt. Robert Hester weTrinth College muDublin, Ireland, uye Dr. Hugh Garavan weTrinth College uye Medical College yeWisconsin muMilwaukee.
Kukuvadza kuDopamine System
"Addictive zvinhu zvakadai secocaine zvinogona kukuvadza dopamine system muuropi, uye kune yakanyanya kukonzerwa kwezvinonzi dopamine receptors muuropi dzenharaunda dzinobatanidzwa mupamusoro-kutonga kugadzirisa maitiro," anodaro Mutevedzeri weNIDA Dr. Nora D. Volkow, news release. "Nokushandisa maitiro anoshanda neuroimaging kuti aongorore kushandiswa kwevashandisi inowanzokonzerwa nekushungurudzwa kwenguva refu kwekodhaine, idzi masayendisiti akacherechedza chimwe chiitiko chekodineine kuitika pauropi iyo inogona kubatsira kutsanangura kuti nei vanhu vachiramba vari mumitemo iyi pasinei nemigumisiro yakaipa."
Muchidzidzo chacho, masayendisiti akanyorera vanhu vanoshandisa 15 cocaine vanoshungurudza uye 15 vane hutano vasina kumboshandisa mushonga. Mumwe nomumwe mubatanidzwa akapedzisa basa ravakarangarira mutsamba yematsamba kwemaawa masere uye "akadzokorora" imwe nhamba kwemasekondi masere.
Pakupedzisira vakamanikidza bhodhi pavakaratidzwa netsamba yakanga isiri chikamu cherwendo rwakapfuura. Panguva yebasa racho, bhodhi dzevadzidzi vacho dzakaongororwa kuburikidza nehutano hwemagnetic resonance imaging (MRI) inoratidzira nerve cell basa panguva yekushanda kweimwe basa.
Cocaine Inobata Mabasa Akakura Okurota
Ikococaine vashandisi vakanga vasina kunyatsokwana kudarika kutonga.
Masayendisiti akawana kuti zvido zvekushanda chiyeuchidzo zvinoda kuwedzera kushandiswa kwezvikamu zviviri zveuropi, anterior cingulate cortex (ACC) uye prefrontal cortex.
"Ongororo yapfuura yakaongorora kusangana kwepfungwa mumagetsi ecocaine vakaona basa rekudzikira mukati mekunze kwekodhekisi," anodaro Dr. Garavan. "Asi kudzidza kwedu ndiyo yekutanga kuratidza kuti kuoma kwevashandisi vekodineine vane kuvhiringidza zviito zvavo, kunyanya kana maitiro akareba ekufunga nekuita zvisarudzo zvichidiwa, vanorondedzera zvakananga nekukwanisa kuderedzwa kwebasa muAAC uye nepamusoro pezvikwata zve ubongo. "
Kunobva:
Garavan, H naHerter, R. "Kusarudzwa Kwekwakakura muCocaine Kunetseka: Uchapupu hweChirangaridzo, Chisingaridzi, uye Cerebellar Activity." Journal of Neuroscience December 2004