Kuwedzera kweNorepinephrine mazinga muuropi anogona kuvandudza simba
Norepinephrine, inozivikanwawo seyo noradrenaline, inosanganisira hormone uye neurotransmitter yeuropi, kana kuti chemikemikari. Inonyanya kuchengetwa mumapurisa (nerve cells) ehurumende yekunzwira tsitsi ine huruku shoma zvakare yakachengetwa muzvinyorwa zvepamusoro, izvo zviri pamusoro peinso dzako.
Semahomoni, norepinephrine inosunungurwa muropa neruzhinji uye inoshanda pamwe neAdrenaline (inozivikanwawo se epinephrin) kupa muviri muviri kamwe kamwe munguva dzekutambudzika, inozivikanwa se "hondo kana kuti ndege".
Sezvinonzi neurotransmitter , norepinephrine inopfurikidza nhubu dzemawere kubva kune imwe neuron kusvika kune inotevera.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
Mishonga inobvisa reuptake ye norepinephrine uye serotonin (iyo imwe yerurotransmitter) inonzi serotonin-norepinephrine reuptake inhibitors (SNRIs). Nokudzivisa reuptake yevaviri vezveuropi, SNRIs inowedzera kukosha mazinga e norepinephrine uye serotonin muuropi. Serotonin inoita kuti munhu anzwe zvakanaka uye norepinephrine inovandudza simba uye kuterera.
SNRIs yakawanikwa ichibudirira pakurapa matambudziko emafungiro akadai sokuora mwoyo, bipolar disorder, uye zvinetso zvekuzvidya mwoyo. SNRIs dzimwe nguva inorondedzerwa kuti urombo husingaperi uye fibromyalgia.
SNRIs yekurapa Matambudziko eMafungiro
SNRIs inobvumidzwa kuti ishandiswe mukudzvinyirira kukuru kunosanganisira Cymbalta (duloxetine), Effexor (venlafaxine) uye Pristiq (desvenlafaxine), asi kune vamwe vanobvumirwa kune dzimwe zvirwere pamwe chete.
Kunyange zvazvo pasina vanodzvinyirira, kusanganisira SNRIs, vakagamuchirwa neU.S. Food and Drug Administration (FDA) pakurapa bipolar disorder, dzimwe nguva inorondedzerwa sechikamu cherongwa hwehutano hwega.
Maitiro Akafanana Maitiro eSNRIs
SNRI inogona kuwedzera ropa rehupenyu hwemunhu, saka chiremba wako angada kuongorora ropa rako kana akaraira imwe.
Kana iwe uchitova nechinetso chekudzora ropa, SNRI inogona kunge isiri yakakosha iwe.
Izvi zvinowanzoitika shure kwemavhiki mashomanana, asi kana vasingakwanisi kana kuti vari kunyanya kunetseka, iva nechokwadi chekutaura nachiremba wako. Zvimwe zvinowanzova nemigumisiro yeSNRIs inosanganisira:
- Chizutu
- Dry mouth
- Kunyorera kupfuura kupfuura
- Kushungurudza mudumbu
- Kuneta
- Headache
- Kurasikirwa nechido chako
- Constipation
- Zvinetso zvepabonde
- Kufunganya
- Zvakaoma kurinha
Mhuri yeSerotonin-Norepinephrine Reuptake Inhibitors
Chimwe chezvinhu izvi SNRIs chikamu chiduku chakasiyana nemamwe.
Effexor (Venlafaxine)
Effexor ndiyo yekutanga SNRI inofanira kugamuchirwa muUnited States muna 1993. Yakabvumidzwa neDDA nokuda kwekuora mwoyo, kutya kwepfungwa, hukama hwevanhu, uye huwandu hwehutano hwepfungwa (GAD). Effexor inhibits yekudzokazve kwe serotonin zvakanyanya kudarika zvinodarika norepinephrine.
Cymbalta (Duloxetine)
Muna 2004, Cymbalta yaiva yechipiri SNRI inobvumirwa muUnited States. nenzira iyo inoshanda, ine ine nhamba yepamusoro yeDAA-inobvumirwa kurapa zvirwere, kusanganisira chirwere cheshuga chinokonzerwa neuropathy, kuora mwoyo, kuwanda kwepfungwa kushungurudzika, fibromyalgia, osteoarthritis, uye kurwadziwa kwepfungwa. Kungofanana neEfficexor, Cymbalta inofarirawo kudzivisa kubviswa kwe serotonin pamusoro pe norepinephrine, asi kusvika pamwero muduku.
Pristiq (Desvenlafaxine)
Pristiq, wechitatu SNRI kuti agamuchirwe. yakangogamuchirwa kutora kuora mwoyo kukuru kusvika ikozvino. Chemhemikari, Pristiq inoshanda zvakafanana zvakafanana neCymbalta.
Savella (Milnacipran)
Iyi ndiyo yechina SNRI inogamuchirwa muU.S. kuti inoporesa fibromyalgia. Savella inoshanda kuburikidza nekudzivisa kubatsiridza zvakare serotonin uye norepinephrine zvakaenzana uye inogona kufarira norepinephrine, maererano nezvimwe zvinyorwa.
Fetzima (Levomilnacipran)
Nhengo iyi ichangobva kuwanikwa yakaziviswa kumhuri yeSNRI, Fetzima yakabvumidzwa neDFA muna 2013 uye yakangove yakava FDA-inogamuchirwa yekurapa kuora mwoyo.
Fetzima inhibits norepinephrine reabsorption kaviri se serotonin reabsorption, ichiita kuti ive yakasiyana pakati peSNRIs.
> Sources:
> Moret C, Briley M. (2011). Kukosha kwe norepinephrine mune kuora mwoyo. Neuropsychiatr Dis Treat. 2011; 7 (Chengetedza 1): 9-13.
> Sansone, RA, Sansone, LA (2014). Serotonin Norepinephrine Reuptake Inhibitors: Kuenzanisa Kwema Pharmacological. Innovations in Clinical Neuroscience . 11 (3-4): 37-42.