Kuzvidzivirira kwezvirwere kunogona kukonzera bipolar-sezviratidzo
Systemic lupus erythematosus (inozivikanwawo se lupus kana SLE) chirwere chinogadzirisa muviri chinogona kukonzera zvirwere zvisingaperi munzvimbo dzakasiyana dzomuviri. Kunyange zvazvo nzira chaiyo ye lupus isingazikamwi, mamiriro acho ekupedzisira anomiririra masimba ezvirwere anenge asisina simba, achirwisa masero anowanzoonekwa nenzira yekutadza seine ngozi.
Pakati penheyo yenheyo ndeimwe yezvinangwa zvekupindura kwemuviri.
Kana zvikaitika, zvinogona kuratidzira nezvirwere zvepfungwa zvinenge zvakafanana ne bipolar disorder .
Kunyange zvazvo zviratidzo zvehutano huviri huripo (sezvinoita zvinodhaka zvinoshandiswa kuvabata), SLE uye bipolar hazvina kufanana. Pasinei nokutenda kwakakurumbira, SLE haina kukonzera bipolar disorder.
Ukuwo rumwe rutivi, SLE dzimwe nguva hazvizivikanwi sebipolar disorder. Kana izvi zvikaitika, munhu angave akaratidzirwa kurapwa zvisina kufanira uye zvisina kukodzera.
Neuropsychiatric Symptoms of Lupus
Apo lupus inokanganisa nheyo yepamusoro yenheyo, inogona kukonzera zviratidzo zvakasiyana-siyana, zvose zveuropiyo uye zvepfungwa. Tinotaura nezvechiitiko ichi seurouropsychiatric systemic lupus erythematosus (NPSLE). Zviratidzo zvinogona kubva pane zvinyoro kusvika kune zvakanyanya uye zvinosanganisira:
- Headaches
- Matambudziko epfungwa, kusanganisira kuora mwoyo uye zviratidzo zvebipolar
- Kurasika kurasika
- Kurasikirwa kwekugadzirisa basa
- Kuvhunduka, tic, uye kushamwaridzana kunoitwa
- Kushungurudzika kana gumbo risingachinji
- Kugumburwa
- Chiratidzo chakasvibiswa
- Kunzwa zvinetso
- Dambudziko rekutaura
- Kuvhiringidzika uye kununura
- Kuenzanisa, kupera, kupisa, kurwadziwa kwehutano
- Stroke
NPSLE inokanganisa makumi mana kubva muzana yevanhu vane lupus, kazhinji vanozviratidza sekuora mwoyo, kukanganwa kwepfungwa, uye kukanganwa kwevanhu vakawanda. Iko kunofungidzirwa sechisungo chakakomba chinotungamirira kumudziro wakaderera wehupenyu uye kuwedzerwa chirwere.
Tsvakurudzo yezvino inoratidza kuti NPSLE inobatanidza nekuwedzera kwegumi kwekufa nekuenzaniswa nevanhu vari vanhu vakawanda.
Zvinokonzera NPSLE
Panzvimbo pane kuva nechikonzero chimwe chete, NPLSE inokonzerwa nekubatana kwezvinhu zvinosanganisira zvirwere zvekudzivirira muviri, zvirwere zvehomoni, kuputika kwemavhutu, uye kukanganisa zvakananga kumatope anotyisa. Kunyange mishonga yemishonga inogona kuita kuti zviratidzo zvivepo. Uyezve, nzvimbo yakachengetedza inopoteredza uropi, iyo inonzi ropa yeropa, inogona kuvhiringidzika ne lupus, ichibvumira kuti inxins ipinde uye inokuvadza neural tishu.
Zvimwe zvezviratidzo zveNPLSE zvinogonawo kufananidzwa nemamiriro ezvinhu anonzi demyelinating syndrome umo kupindurwa kwemoto kunopedza zvishoma nezvishoma myelin sheath (funga nezvayo sevhavha inovhara) yeropa. Zvichienderana nezvinoitika izvi, zvinogona kukonzera zvakasiyana-siyana zvekunzwisisa, kunzwisisa, uye zvinetso zvekuona.
Kuongororwa kweNPSLE
Nokuti zvakaoma kusiyanisa pakati pezvikonzero zvakasiyana-siyana zveNPSLE (kusanganisira kuzvimirira kwezvirwere zvepfungwa), hapana mhando yegoridhe yekuongororwa. Sezvo zvakadaro, kuongororwa kunowanzoitwa nekuregererwa, kuongorora zvimwe zvinokonzera zvinokonzerwa nekutapukira, zvirwere zvinokonzerwa, pamwe nemigumisiro yemishonga.
Izvi zvinowanikwa pane imwe nyaya-ne-zvikonzero zvayo pasi pekutungamirirwa kweumwe nyanzvi anoziva muNPSLE.
Kana chirwere chinonzi demyelination syndrome chikafungidzirwa, kuongororwa kunogona kuitwa kuitira kusimbisa kuvepo kwezvimoto zvinokonzerwa ne autoimmune (autoantibodies) inosanganiswa ne myelin kukuvara.
Kurapa kweNPLSE
Kazhinji kutaura, mishonga inoshandiswa pakurapa zvirwere zvepfungwa nemafungiro inogonawo kushandiswa kurapa zvirwere zvepfungwa zveplus.
Muchiitiko cheNPSLE yakasimba, kurapwa kuchashandiswa pakushandiswa kwemishonga inopedza uye yekuenzanisa mhinduro yekuzvimirira. Zvisarudzo zvinosanganisira high-dose corticosteroids (yakadai se prednisone kana dexamethasone ine intravenous cyclophosphamide).
Mamwe marapirwo akadai anosanganisira rituximab, intravenous immunoglobulin (antibody) therapy, kana plasmapheresis (plasma dialysis). Zviratidzo zvinyoro kuenzanisa zvingave zvichirapwa nemuromo azathioprine kana mycophenolate.
Zvakakosha kucherechedza, zvisinei, kuti maitiro makuru e corticosteroids anogona kukurira kushungurudzika kwepfungwa uye, muzviitiko zvisingaiti, zvinotungamirira ku psychosis.
> Sources:
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> Ho, R .; Thiaghu, C .; Ong, H ;; et al. "Meta-Kuongorora Serum neCerebrospinal Fluid Autoantibodies muNeuropsychiatric Systemic Lupus Erythematosus." Autoimmunity Reviews . 2016; 15 (2): 124-38.
> Magro-Checa, C .; Zirkzee, E .; Huizinga, T .; uye Steup-Beekman, G. "Mutungamiri weNeuropsychiatric Systemic Lupus Erythematosus: Nzira Dzozvino uye Zuva Rinozoitika." Zvinodhaka . 2016; 76 (4): 459-83.
> Shimizu, Y .; Yasuda, S ;; Kako, Y .; et al. "Post-Steroid Neuropsychiatric Zviratidzo zvakajeka zvakanyanya kuwanda muSLE Kusienzaniswa nedzimwe Zvimwe Zvirwere Zvirwere Zvirwere Zvirwere uye Kufanirwa Kubudirira Zvakanaka Kuenzaniswa neDe Novo Neuropsychiatric SLE." Autoimmunity Reviews . 2016. 15 (8): 786-94.
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