Genetics yeBipolar Disorder
Kana iwe une bipolar disorder uye uri kufunga kuve nevana, imwe yemibvunzo yaunenge uchizvibvunza iwe ndeyekuti iwe ungapfuura bipolar disorder yako kune mwana. Bipolar disorder hereditary? Ndeipi iyo inonzi genetics mu bipolar disorder?
Bipolar Disorder Hereditary?
Takaziva kwenguva yakati kuti bipolar disorder inogona kufamba mumhuri, uye iye zvino, ne genomic sequencing, tiri kudzidza nezvemaitiro anokonzerwa nemararamiro mune chirwere.
Kunyange zvazvo basa rekuzvarwa kunoratidzwa pachena kubva kumhuri uye mapatya maviri, kutsvakurudza kwakawedzerwa kunodiwa.
Zvose zvinotarisana nehupenyu hwekudzidzira bipolar disorder inofungidzirwa kuva pane imwe 1 kubva ku4 muzana, zvichienderana netsanangudzo, uye inenge yakawanda yemakore pakuongororwa iri 18.
Ngatitarisei zvatinoziva nezvehupenyu hwemhuri nehutano hwepipolar, uye ipapo pane zvipi zvezvemagariro zvakawana pamusoro pebasa remajeni ega ega muhutano hwepipolar uye mamwe matambudziko ehutano hwepfungwa.
Mhuri Nyaya yeBipolar Disorder
Bipolar disorder inofungidzirwa kuti ndiyo imwe yezvinetso zvakakosha zvehutano hwepfungwa zvichibva pakuongororwa kwemapuranga emhuri. Semuenzaniso, heino nhamba kubva pane chidzidzo icho chakawana ukama hwemhuri hwakakura ne bipolar disorder:
- Mwana wemubereki mumwe ane bipolar disorder uye imwe kunze ane 15 kusvika ku30 mukana wekuva neBP.
- Kana vabereki vose vane bipolar disorder, pane 50 kusvika kuzana 75 mukana kuti mwana wavo wavo, zvakare.
- Kana iwe uine mwana mumwe chete ane BP, kune 15 kusvika ku25 mukana yekuti imwe yevana vako ichave nayo.
- Kana rimwe rimwe rakafanana nemapatya rine BP, pane anenge 85 muzana mukana wekuti mumwewo achaitawo saizvozvo. Mune zvimwe zvidzidzo zvitatu, mukana wemajaya akafanana uye ane bipolar disorder ranges kubva 38 kusvika 43 muzana uye yeavizygotic (isina kufanana) mapatya ari pakati pe4,5 ne5,6 muzana.
Dzimwe tsvakurudzo dzakawanda dzakaona kuti bipolar disorder inomhanya mumhuri, kunyange isiri yose kune iyi dhigirii. Zvimwe zvinhu zvebipolar disorder zvinoratidzikawo kuti zvinomhanya mumhuri dzinosanganisira kuwedzera kwekurwara ( mania vs kushushikana,) kuwanda kwezvikamu, kuvapo kwepfungwa , kuzviuraya, nokukurumidza-mabhasikoro, kusanganisira kushandiswa kwezvinodhaka zvinoshandiswa, kunetseka kwezvinodhaka, uye kuterera (kana kuti kushayikwa kwayo) kumishonga yakadai se lithiamu nezvimwe zvinodhaka.
Nguva yekutanga bipolar disorder inowanzova duku kuvana vana vane vabereki kana vanasekuru navanasekuru vane chirwere chakanyanya kuora bipolar.
Genetics vs Environment uye Bipolar Disorder (The Nature vs Growture Controversy)
Apo bipolar disorder inomhanya mumhuri inobvunza mubvunzo uyu: Ndiyo kuwedzera kwengozi yakabatana ne genetics (inogadzirisa zvizere zvegene) kana kuti pane nzvimbo yakasikwa. Zvinoratidzika kuti nzira mbiri idzi dzinogona kunge dzichitamba uye dzinobatsira kukonzera bipolar disorder .
The Genetics of Bipolar Disorder
Kunyange zvazvo inotambudza mumhuri, zvakaoma kutsanangura mazita chaiwo ehutachiona hunokonzera. Zvidzidzo zvinotarisa genetics ye bipolar disorder zvakakundikana kuwana girasi rimwe chete rinokonzera (semuenzaniso, sezvinoitika ne cystic fibrosis.) Pane kudaro, zvinoita sokuti kune dzakawanda dzemu chromosomal nzvimbo dzine majini akawanda (polygenic,) imwe neimwe iyo inobatsira zvishoma pakusimudza kukanganisa kune chirwere.
Zvimwe zviri mumagenjini akadai se ANK3, CACNA1C, NCAN, ODZ4 uye inofungidzirwa kuti iwedzere kunzwisisika asi tsananganidza chete shoma shomanana yehutachiona hunogona. Mukuwedzera, ruzhinji rwevanhu vane "zviitiko zvekutambura" havakwanisi bipolar disorder.
Genetics uye The Response to Bipolar Medication
Nhaurirano yakasiyana yakave ichinyatsonzwisiswa nekunzwisisa kwedu mutsva kwema genetics ndeyekuti genetics inogona kuita kuti munhu apindure sei mishonga ye bipolar disorder. Semuenzaniso, avo vane mapepa maviri asina kushandiswa eYP206 geni vangave varombo maserolizers emishonga yakadai sa respiradone uye aripiprazole.
Sezvataurwa pamusoro apa, zvakadini munhu anopindura zvinodhaka zvakadai se lithiamu inogona kufamba mumhuri.
Genetics yeBipolar Disorder uye Dzimwe Matambudziko Ehutano hweMental
Mukuona kutarisa kwemajeni, zvakave zvichitaurirana kuti ivo vanobatana pakati pegene kuchinjwa kunonzi bipolar disorder uye schizophrenia , schizoaffective disorder , uye kuora mwoyo .
Unofanira Kuva Nevana Kana Une Bipolar Disorder?
Kuziva kuti pane kuwedzerwa kwehutano hwehupfungwa hwebipolar muvana veavo vane bipolar disorder, vabereki vanofanira vane chirwere vane vana here?
Uyu mubvunzo usina mhinduro yakarurama kana isina kururama. Kune zvakawanda zvirwere zvehutano zvinogona kunge zvine nhaka. Mukuwedzera, hakuna rimwe gena kana mararamiro emagetsi ano "kuvimbisa" mwana achakurira bipolar disorder.
Zvakakosha kucherechedza kuti hapana chinotaura kuti kuva nemwana anoita kuti chirwere chepfungwa chinetseke hachizove chiitiko chinoshamisa.
Mhinduro yakarurama ndeyekuti vabereki vanofanira kusarudza zvakanakire ivo pachavo nevana vavo remangwana. Kuziva kuti une nhoroondo yemhuri, zvisinei, inogona kubatsira zvikuru pakuchengeta mwana wako anofanirwa kuratidza chero zviratidzo kana zviratidzo kuitira kuti aone mamiriro acho asati agadziriswa.
Pasi pepamusoro paGenetics, Heredity, uye Bipolar Disorder
Zvinoratidzika zvakajeka kuti kune mazita ekuberekwa kwemaitiro ekuvandudzwa kwebipolar disorder, asi basa iri rinoratidzika se polygenic (rakarongedzwa zvishoma nejena rakasiyana-siyana) uye rakaoma kwazvo. Mune mamwe mazwi, hapana kana rimwe divi rinenge rakasiyana-siyana rinokonzera bipolar disorder, pane kudaro, zvakasiyana-siyana zvemajeni zvinogona kuwedzera kukwanisa kwevanhu kukura bipolar disorder. Mhuri yehutano hwechirwere haisi chikonzero chekusiya kuva mubereki. Iwe unogona kuda kudzidza pamusoro pemabhogi mutsvuku kwebipolar disorder muvana , uye mhando dzakasiyana dzechirwere .
> Sources:
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> Craddock, N., naP. Sklar. Genetics yeBipolar Disorder. Lancet . 2013. 381 (9878): 1654-62.
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