Bhokisi Remafu Inyevero yeAntipsychotic Clozaril
Clozaril (clozapine) mishonga inorwisa antipsychotic yakagamuchirwa kuti ishandiswe mukurapa kusagadzikana schizophrenia uye nekuderedza dambudziko rekuzvipira kuzviuraya kune varwere vane schizophrenia kana schizoaffective disorder avo vanotaridzirwa kuti vari panjodzi dzisingagumi yekudzokororazve kuzviuraya, zvichienderana nhoroondo uye zvekuchipatara kwenyika.
Mirairo inokosha yeClozaril (Clozapine)
Clozaril ane nyevero shanu yakakomba , inonzi black box warnings, pamusoro pemigumisiro yakakomba yakawanda uye kushandiswa kwemishonga. Nokuda kwezviyeuchidzo izvi, Clozaril inogona kungorongerwa kuburikidza nehurongwa chaiwo unodzivisa kuparidzirwa kunonzi Clozapine Risk Assessment uye Maitiro ekuderedza (REMS) Programme. Vose vaviri chiremba wako uye wemhizha yako inofanirwa kunyoresa nepurogiramu iyi iyo vaiti vezvigadzirwa vakagadzirira kuitira kupa nekuparadzira Clozaril yako. Purogiramu ye REMS inochengetedza kuongororwa kweWBC count uye ANC maererano neshepfenyuro inotsanangurwa pasi apa isati yatanga kushandiswa kwechipiri chinopa mishonga.
Agranulocytosis
Agranulocytosis is an abnormally low white cell count count. Sezvo masero machena eropa akadikanwa kurwisana nezvirwere, izvi zvinogona kunge zvinouraya. Vashoma kupfuura 1% yevarwere vanotora Clozaril vanogona kukura agranulocytosis, chiitiko chinogona kutyisa upenyu.
Kana iwe uri kurapwa ne clozapine, unofanira kuva nesero rekutanga rechechi yeropa (WBC) uye nhamba yakazara yeutrophil (ANC) usati watanga Clozaril, uyewo nguva dzose yeWBC nhengo dzeANC panguva yekurapa uye kwevhiki dzinenge 4 pashure kuregererwa kwemishonga.
Ngozi Yekutambudzika
Kukanganiswa kwakabatanidzwa nekushandiswa kwe clozapine.
Dose inoratidzika kuva chiitiko chinokosha chekugumburwa, pamwe nehuwandu hwepamusoro yevhazapine doses. Kuchenjerera kunofanira kushandiswa paunotarisira clozapine kune varwere vane nhoroondo yekukundwa kana zvimwe zvinokonzera zvinhu. Varwere vanofanira kurairwa kuti vasaita chero basa ripi umo kurasikirwa kamwe kamwe kwekuziva kungakonzera ngozi huru kune ivo kana kune vamwe.
Myocarditis uye Cardiomyopathy
Myocarditis kuvhiringidza kwemwoyo yemisvo uye kushaya mwoyo kune mwoyo wakawedzerwa. Kana uine kupera kwekufema, fivha, kunyanya kuneta kana kurwadziwa kwepfuva paunotora Clozaril, iva nechokwadi chokuti utaure nechiremba wako pakarepo.
Zvimwe Zviremera ZveMwoyo Mikana uye Inopfurikidza Migumisiro
Orthostatic hypotension yakakura, kamwe-kamwe kunokonzerwa neropa pamusana pekumira izvo zvinoita kuti unzwe uine mvere mutsvuku kana kuti chizoro. Syncope inoreva kupera.
Orthostatic hypotension, kana kuti pasina syncope, inogona kuitika nekurapa ya clozapine, kunyanya paunotanga kuitora kana kuti chirwere chako chinoshandurwa. Kazhinji, izvi zvinogona kuva zvakadzama uye zvinoperekedzwa nekuputika uye / kana kusungwa kwemwoyo. Kana uine chirwere chakanyanya kana kurutsa kana zvimwe zviratidzo zvekushaya mvura, iva nechokwadi chekuudza chiremba wako. Uyezve, kana iwe uchinge uchinge wapura maviri kana kupfuura yaClozaril, taura nachiremba wako usati watora mukana wako unotevera iwe ungave uchida kutora chirwere chiduku kwenguva.
Kuwedzera kwekufa muvatana vakwegura vane dhementia
Varwere vakwegura vane chirwere chepfungwa chinokonzera kuora mwoyo kwemazuva ano vanobatwa nemishonga inorwisa antipyychotic vari pahuwandu hwekufa huenzaniswa ne placebo . Mune rumwe ruzivo, kunyange zvazvo zvikonzero zvekufa zvaive zvakasiyana-siyana, dzakawanda zvekufa zvakaonekwa kunge zviri mwoyo, zvichireva kuti dzakanga dzakabatana nemoyo wekukundikana kana kufa kamwe kamwe, kana kutapurirwa mune zvakasikwa. Clozaril haibvumirwi kurapwa kwevarwere vane chirwere chepfungwa chinokonzerwa nekuora mwoyo.
Sources:
"Clozapine (Clozaril / FazaClo)." National Alliance on Mental Illness (2014).
"Clozapine." MedLine Plus, US National Library of Medicine (2015).