Modafinil (Provigil) inoshandiswa kubata chirwere chekurara, chirwere chinoputika uye zvimwe.
Vanhu vazhinji vanoshandisa zvisina kunaka kugadzirisa-kugadzirisa kana psychostimulant zvinodhaka mune unyanzvi husina kunyorwa kuitira kuti kuwedzere kubereka, kurwisana kuneta uye kubatsirana nezvinetso zvepfungwa. Kunyange zvazvo kushandiswa kwekutsvaga kwekushandisa-zvinodhaka zvinodhaka zvakadai seamphetamine, methylphenidate, uye modafinil (Provigil) inowanzobatanidzwa nevadzidzi veyunivhesiti - inofungidzirwa kuti 7 kusvika ku20 muzana yevadzidzi vekuUkoloni vadzidzi vakashuma kushandiswa kwemishonga - mamwe mapoka anoshamisa evanhu vanoshandisa zvisina kunaka izvi zvinodhaka, zvakare.
Somuenzaniso, 8,9 muzana yevashandi vanovhiya vakaongororwa muGermany vakarondedzera kushandiswa kusina kunyorwa kwezvinodhaka-zvinowedzera zvinodhaka.
Modafinil inofanirwa kunge isina kudhakwa kupfuura dzimwe psychostimulants yakafanana neamphetamine; zvisinei, isu tisati tanyatsonzwisisa kuti chirwere ichi chinoshanda sei kana kuti yakareba kwenguva yakaipa. Uyezve, modafinil inogona kukonzera mimwe miitiro yakaipa uye inofanira kutorwa chete kana yakarongerwa nachiremba.
Chii Modafinil?
Modafinil dzimwe nguva anonzi "kukamuka-kukurudzira agent." Vatsvakurudzi vanodavira kuti mishonga iyi inoshandisa kuburikidza nekuwedzera kwema-synaptic kuwanika kwevana neurotransmitters vakaita se monoamines, catecholamines, dopamine, serotonin, adenosine, histamine uye noradrenaline. Modafinil inokanganisa hypothalamus, hippocampus, uye amygdala izvo zvikamu zvehuropi.
Modafinil ipiritsi inotorwa nemuromo kazhinji kamwe-ne-zuva. Vanhu vazhinji vanoshanda masikati vanotora mushonga mambakwedza paine dumbu rakazara kana risina chinhu. Zvisinei, vashandi vanoshandura vanotora mishonga kuti vakurudzire kumuka vatore mishonga vasati vachinja matangi.
Modafinil Anoitei?
Modafinil inoshandiswa kubata zvirwere nekuziva, kumutsa, nekumuka. Mamwe mamiriro ezvinhu anobatwa ne modafinil anosanganisira zvinotevera:
- Dambudziko rekunyengera
- Shift-work sleep disorder
- Kudzivisa kubatwa nehope
- Kukuvara kwepfungwa kunetseka
- Adjuvant kurapa kuora mwoyo
- ADHD
- Kuchengetedza kana kuguma-kwe-upenyu kutarisira
Nekuremekedza kuchengetedza kurapa kana kuguma-kwe-hupenyu, nyanzvi dzakawanda dzinosarudza kuisa pfungwa dzepfungwa dzakadai se modafinil nokuti dzinovandudza mafungiro ekukurumidza kupfuura mishonga yepfungwa. Uyezve, kuvimba hakusi kunyanya kunetseka panguva yekupedzisira-ye-hupenyu hwekutarisira.
Migumisiro yakaipa
Migumisiro yakaipa zvikuru yeModafinil inosanganisira zvinotevera:
- Kudzora
- Nausea
- Kushungurudzika
- Kufunganya
Mimwe migumisiro yakaipa inosanganisira zvinotevera:
- Kunyunyuta
- Diarrhea
- Constipation
- Sweating
- Hoarseness
- Kuoma kufema kufema
- Chipfuva chepfu
- Kusagadzikana kwepfungwa
- Kuda kuzvipira (pfungwa dzekuzviuraya)
- Hlulucination
- Mapundu
- Blisters
- Hives
Mimwe yemigumisiro iyi yakaipa inotyisa uye ine ngozi saka iva nechokwadi chekuonana nechiremba wako kana iwe ukaona chero ipi zvayo.
Uyezve, mamwe emigumisiro iyi yakaipa yakadai sekusuruvara, kusagadzikana, kurwadziwa kwepfupa, kushungurudza, nekunyonganiswa kunogona kukonzerwa nekudarika kwepamusoro ne modafinil. Kana iwe uchifungidzira kuwedzeresa, danai mabasa ekukurumidzira kana kuti taura nachiremba pakarepo.
Contraindications
Modafinil haisi yevanhu vose, uye pamberi pechiremba wako asati akuraira mishonga iyi, unofanira kumuudza nezvekutevera:
- Allergy ku modafinil kana armodafinil (anantianomeri we modafinil)
- Kushungurudzwa kwemishonga kunosanganisira SSRIs, TCAs, uye benzodiazepines
- Antiseizure mishonga se phenytoin uye carbamazepine
- Antifungal mishonga inonzi itraconazole uye ketoconazole
- Kushandisa zvinodhaka zvisina kunaka kana kuvimba
- Vitamine, kuwedzerwa kwezvokudya zvinovaka muviri, uye mishonga inowedzera
Vanhu vane angina kana kuti munguva pfupi yapfuura vane chirwere chemwoyo havafaniri kupiwa modafinil. Uyezve, hazvina kunyatsojeka iyo iyo modafinil inobata chikumbaridzo. Nokudaro, modafinil inogona kuva nengozi kune vanhu vane chirwere chekufa uye zvimwe zvinetso zvekukunda.
Hapana huongorori kwenguva refu pamusoro pemigumisiro ye modafinil pauropi. Chiremba anofanira kunyatsocherechedza kana kuti anyore modafinil uye akayera kubatsirwa kwezvinhu zvayo zvinokurudzira uye zvinogona kuva nemigumisiro yakaipa.
Kunyange zvazvo modafinil zvichida kusanyanya kuwedzera kune zvimwe zvinokurudzira zvakadai seamphetamines uye methylphenidate, zvinogona kunge zvichitungamirira kukuvimba.
Ndapota zivai kuti nguva dzose apo chiremba anoita chisarudzo chekupa modafinil, sarudzo iyi ndeyechero. Mune mamwe mazwi, kana iwe wakanyorerwa modafinil kana imwe yimwe psychostimulant, iyi mishonga ndeye iwe chete. Iwe haufaniri kugovana kana kutengesa modafinil-kana chero chero chirwere chemishonga chechiitiko ichocho. Kusiyana kwakadaro kunokuvadza uye hakubvumirwi nemutemo.
Sources
Liu D, Norman MA, Singh B, Lee K. Kuora mwoyo uye Mamwe Matambudziko Ehutano Hwepfungwa. Mu: Williams BA, Chang A, Ahalt C, Chen H, Conant R, Landefeld C, Ritchie C, Yukawa M. eds. Ikozvino Kuongorora nekurapa: Geriatrics, Second Edition . New York, NY: McGraw-Hill; 2014.
Siu G. Pharmacotherapy. Mu: Maitin IB, Cruz E. eds. KUBATSIRA KUTAURIRWA & Kurapa: Physical Medicine & Rehabilitation . New York, NY: McGraw-Hill; 2015.
Nyaya yakanzi "Kuwedzera kwekuziva nezvekugadzirisa zvinhu kunoshandiswa pakati pevadzidzi veNew Zealand vepamusoro" neSam uye vanyori vanyori kubva kune Drug uye Alcohol Review yakabudiswa muna 2015.