Chii Chinonzi Dopamine Dopamine?
Muchikamu chino, iwe uchadzidza nezve dopamine chikamu chegonism. Izvi zvinonyatsoenzanisirwa na aripiprazole (zita rechiratidzo: Abilify), yechizvarwa chechipiri antipsychotic / atypical neuroleptic iyo inomira kunze kweimwe yose inypical antipsychotics nokuda kwekuita nenzira yakasiyana yekuita.
Aripiprazole yakasiyana sei nedzimwe Atypicals?
Nzira dzakawanda dzinopesana nemasikirwo anonzi antipsychotics ane chimiro chakajeka cheuropi serotonin receptors asi zvakanyanya kusimba uye zvisingakwanisi muuropi dopamine receptors.
Aripiprazole yakasiyana nedzimwe dzakawanda dzeatypicals maererano nehutano hwekuita. Muchidimbu, aripiprazole inoshanda kuburikidza nedopamine. Nokudaro, kubva pakuona kwaro inoshanda, aripiprazole iri pedo kune inowanzoonekwa kana kuti chizvarwa chekutanga chinonzi neuroleptics, icho chinobatana nekuvhara dopamine muuropi (zvinonzi dopamine antagonism) sechinhu chinowanzogadzirisa chiito.
Kana Aripiprazole Ichishanda paDopamine Nei ichitsanangurwa seAtypical?
Chikonzero chacho chiri chirwere chekuropiprazole : chiitiko chayo chekuti zvimwe zvirwere zvinokonzerwa neurological zvinokanganisa zvakadai sezvikamu zvehutachiona hwehutachiona hutsika (dystonia) kana kusazvibata kusina kuipa kwevhiringidzi (dyskinesia) yakaderera, iyo inowanikwa iyo inowirirana seyesu; zvinopesana nevanopesana nehutachiona ane ngozi yakawanda yehutachiwana hwemhando iyi yemigumisiro yakaipisisa, iyo inorondedzerwa seye typicals.
Aripiprazole inonzi dopamine partial agonist - asi inopesana nemudzivisi weDopamine kana blocker sainowanzozvarwa antipsychotics.
Chii chinonzi Dopamine Antagonism?
Dopamine ndeimwe yemapurisa eurotransmitter anowanikwa pamwero we synaptic space, nzvimbo mukati-neuroni. Dopamine inosunungurwa mu synaptic nzvimbo kubva kuma vesicles inogara mu-pre-synaptic neuron, zvino inosunga kune dopamine receptors pamwero we postsynaptic neuron.
Funga pamusoro peizvi sechinhu chakakosha uye cheki chekuita apo dopamine receptors ndiyo inovhara iyo inozaruka apo dopamine "key" inopinda mukati. Chimwe chezvifungiro zvechichichiphrenia ndechokuti mune dzimwe nzvimbo dzeuropi kune dopamine yakawandisa mu synapse. Zviratidzo zvinoratidza schizophrenia zvinofungidzirwa kuti ndezvikonzero zvezvose izvi "zvekare" dopamine molecules dzinosunga kuti dopamine receptors. Vanopikisa Dopamine vanosunga kune dopamine receptors, saka kudzivisa dopamine kusunga. Uye kunze kwekona chaiyo, kureva dopamine, ichocho hachizaruri - mune mamwe mazwi, sezvo dopamine dambudziko rinodarika rinoruramiswa pamwero we synapse hapana maitiro akaipa (zviratidzo zvakanaka) zvinokonzerwa naro. Chinetso chacho ndechokuti dopamine blockade inowanikwa kwose kweuropi apo dopamine yakawandisa mune schizophrenia inongogumira kune zvimwe zvikamu zveuropi. Uyezve, mune schizophrenia, asi dzimwe nhengo dzouropi dzinotarisana nedopamine kudarika, dzimwe nhengo dziri kunyatsoona dopamine. Vanopikisa Dopamine havangoiti kuti zviputi zviwanike mune dzimwe nzvimbo kune zvakawanda kwazvo asiwo munzvimbo dzisina dopamine yakakwana. Ichi ndicho chikonzero nei mishonga iyi, iyo ichishanda kune zviratidzo zvakanaka - nekuda kwekuvhara mapepa emakorokori nzvimbo dzine dopamine yakawandisa, inowanzoitawo kuwedzera zviratidzo zvisingaiti , kugadzirisa pfungwa, uyewo ngozi ye parkinsonism kune varwere vanovatora, nekuda kwekuvhara ye dopamine muuropi nzvimbo dzisina dopamine shoma.
Chimwe chinogona kugadzirisa dambudziko iri kushandisa varonti vashoma.
Chii chinonzi Partial Dopamine Agonist?
A partial dopamine agonist iro molecule inosungirirwa kune iyo inogadzirisa uye inokonzera zvishoma. Funga pamusoro payo seyiyi iyo inofanirwa kuve yakagadzikana mucheki kuitira kuti suo rinyatsogadziriswa asi risati rakasununguka zvachose. Izvozvo zvinokonzerwa nechikamu chinonzi dopamine agonist chakashata kupfuura zvese zvakakwana zve dopamine asi zvinopfuura kuperevedza kwakakwana, izvo zvinoitika apo mukana wacho wakadziviswa zvachose. Mune mamwe mazwi, kushanda kwechikamu. Izvi zvinoreva kuti kana pane dopamine yakawanda zvakapoteredza aripiprazole (a partial dopamine agonist) nokutora dopamine nzvimbo pane zvakagadziriswa uye kuvabatisa chete zvishoma zvichazobvisa chibereko che dopamine yakawanda.
Izvi zvinoreva zvakare kuti mumamiriro ezvinhu apo pane dopamine shoma zvakapoteredza kuti iite zvose zviripo zvinogamuchirwa aripiprazole zvichanyatsobatanidza kune vasina kuchengetwa zvakagadziriswa uye zvayo, kunyange kana zvisingasaruri, ikozvino kuwedzerwa ku dopamine effect mu synapse nokuda kwekuwedzera kwe iyo dopaminergic inokonzerwa nedopamine-yakasimwa chechiapse.
Kutaura muchidimbu, aripiprazole, sechinhu chinokonzera dopamine agonist, inoshanda se modulator ye dopamine madhara. Kana iripo, inoderedza migumisiro yezvose dopamine kudarika (nokuderedza dopamine chiito kana pane zvakawanda kwazvo) uye kukanganisa (kuburikidza nekuwedzera dopamine chiito kana pane zvishoma zvayo).
Kuverenga Zvakare
Arvid Carlsson: Dopaminergic kuperevedza kwechikonzero chechichichiphrenia: nzira yekutsvaga. Dialogues Clin Neurosci. Mar 2006; 8 (1): 137-142