Memoir Skywriting, NBC-TV, amaikadzi vepanhau Jane Pauley vakazivisa kuti ane bipolar disorder. Chirwere ichi chakaonekwa, anoti, paakapiwa steroids nokuda kwemukoko we mikoko. Ichi chizaruro chinonyanya kukoshesa ukama huri pakati pe steroid uye manic kuora mwoyo.
Pauley anonyora, muchikamu chebhuku rake akabudiswa munaAugust 20, 2004, Vanhu, kuti akawana hypomania shure kwekutanga kutungamirirwa kweSteroids kumumumuri uye kuora mwoyo kwechipiri.
Kuora mwoyo kwaiva kwakakomba zvakakwana kuti chirwere chakanyanya kuderedzwa chakanyorerwa kwaari, uye chakasvibiswa kuva nechisimba chakavhenganiswa nenyika uye nokukurumidza mabhasikoro. Chiremba wake akatsanangura, anoti, "Anodzvinyirira" akadzinga munhu asina kumbofungidzirwa kuti anokwanisa kuora mwoyo bipolar. " Asi chaizvoizvo, mafungiro aya ainge atanga izvi zvisati zvaitika - ne-steroids. Akange ari muchipatara panguva iyoyo uye akadzikama pa lithiamu.
Ndezvipi Steroid?
Maererano nePDR Medical Dictionary, izwi rokuti "steroid" rinoshanda kune "mhuri huru yemakemikari zvinhu, ine mahomoni akawanda, zvikamu zvemuviri, uye zvinodhaka." Ndiwo "mazita ekugadzirwa kwemakemikari akabatanidzwa zvakanyanya mukugadzirwa kune steroid, sterols, bile acids, glycosides yemwoyo, androgens, estrogen, corticosteroids, uye vanomirira mberi mavhithamini D" (2000). Zvechokwadi hazvidikanwi kuziva kuti izvo zvipi zvacho-asi pachena, muviri wemakemikari uye mabasa anoumbwa,, anotungamirirwa, kana kusanganiswa nezvinhu izvi zvakakura.
Zvakachengeteka kutaura kuti hapana chinoitika mumutumbi kunze kwekubatanidzwa kwe steroid. Saka, haifaniri kushamisika kuti steroid inobatsira inogona kukonzera migumisiro, iyo "steroid psychosis" ndeye imwe yenyaya yakagadziriswa. "Steroid psychosis - kana zvakakosha, steroid-induced inorwara yepfungwa - inogona kusanganisira psychosis, kushungurudza mafungiro (semuenzaniso, kuora mwoyo, mania, kana zvose), uye delirium" (Cortlandt Letters, December 2001).
Anabolic steroids, inoshandiswa nechizvarwa chevatambi kuvaka musumbu nehuwandu kusvikira yakawanda yakaipa migumisiro yakaonekwa yakawanda yemishonga iyi yakarambidzwa, inogona kuita kuti mania iite. Iyo corticosteroids, iyo ingadai yaisanganisira mishonga yakagadzirirwa mikoko yaJane Pauley, yakaratidzwa kuita zviratidzo zvepfungwa mune zvidzidzo. Mu "Steroid-Kutengesa Kunetseka Kwepfungwa" (Perry & Lund, rakadzokororwa muna 2004), vanyori vanotaura nezvekuongorora kwakaitwa muna 1972 neBoston Collaborative Drug Surveillance Programme apo varwere vakatora maitiro akasiyana ePrednisone (a corticosteroid), kubva pasi kusvika kune yakakwirira, kunowedzera kuwedzera kwekutambudzika kwepfungwa: psychosis, mania, uye kuora mwoyo. Iyo pepanhau inotaura zvakare kuti apo mania ndiyo inonyanya kupindura kushandiswa kwe steroids, kuora mwoyo kunowanzokonzerwa nesteroid kurega.
Vamwe vanoziva steroid yezvokurapa uye kushandiswa kwavo
Mamwe emamwe mazita anozivikanwa zvikuru e-corticosteroids anosanganisira:
- Cortisone uye Hydrocortisone
- Flonase® (fluticasone propionate nasal spray)
- Lanacort® (hydrocortisone topical)
- Prednisone
- Nasonex® (mometasone nasal)
Uye kune dzakawanda zvakawanda zvingadai zvisingasviki pakukura kwechikamu ichi kuedza kutumidza vazhinji vavo.
Corticosteroids inoshandiswa mukurapa kwezvirwere zvakasiyana-siyana zvehutano kusanganisira:
- Asthma
- Emphysema
- Chirwere cheCrohn
- Bursitis
- Tendinitis
- Ulcerative colitis
- Hives
- Insect bites
- Nasal miviri
- Eczema
- Psoriasis
DHEA
Pamusoro pezvokutengeserana kweimwe steroid hormone, DHEA, yakasvika mumoto kubva kune vakawanda vari munharaunda yezvokurapa - mumwe muongorori akaidana kuti "nyoka yemafuta ye" 90s. " Markowitz, Carson, naJackson (1999) vanorondedzera, "... (DHEA) ndeimwe yemaserodi akawanda muviri wevanhu uye inoita seine mabasa akasiyana-siyana ehupenyu. Kukurudzirwa kwekuchangobva kuwanikwa uye kuwanika sekunge kune-over-the-counter kuwedzera kuvanhu vose kwakaita kuti kupararira kushandiswe.
Chinyanyozivikanwa nezvemigumisiro inogona kuipa yeDHEA kana inopedzerwa pachirwere kana chisingaperi. Isu tinoshuma nyaya ye mania mune murume akwegura anobvuma kubasa redu rezvepfungwa risati rave nemunhu wekare kana wemhuri nhoroondo yebipolar disorder iyo yakaratidzika kuva yakabatana neDHEA inoshandiswa munguva ichangopfuura. Murwere akanga atanga DHEA kushandisa mwedzi mitanhatu asati adzoka uye akanga achitora 200-300 mg / zuva panguva yekuratidzwa. "Zvinosuruvarisa kuti vatengesi vakasiyana-siyana vakati DHEA" zvinoshamisa "zvinodhaka kana tsime revechiduku. .
Maererano nehuongorori hwezvepfungwa Dr. Henry Lahmeyer, steroid isina kushandiswa isingakonzereki kukonzera chero mhando ipi yekushungurudzika kwepfungwa; asi, ihwo huwandu hunogara huripo uye huchigadziriswa hwe steroid iyo maitiro emapfungwa anogona kuonekwa. Mumamiriro aPaley, aive achitora steroidhi kwemwedzi mishanu kusati kwamboitika mafungiro.
Kutsvakurudza mabhuku ezvokurapa uye zvepfungwa zvakakodzera kunobereka zvidzidzo zvezviitiko zvakasiyana, zvakadai sezviri kutaurwa kare, izvo zvinoratidza kuti steroid inoshandiswa inogona kukanganisa zviitiko zvekuvhiringidzika kwepfungwa. Uye apo kutsvakurudza kusati kwazarura chikonzero chaicho chezviitiko izvi, zvimwe zvitsva zviri kutanga kujekesa mubvunzo uyu. Wood et al (2004) inorondedzera kuti mukutsvakurudza nemakonzo, kusagadzikana kusingaperi, pamwe nekugadzirisa kushungurudzika kwehomoni corticosterone, kunokonzera kuchinja kwemuviri mukusanganiswa kweveuroni mu hippocampus, chikamu cheuropi. Iko kushandura kunoenderana nekuchinja kwetsika.
Parizvino hapana tsvakurudzo inopa chiratidzo chokuti steroids inogona kukonzera kusagadzikana kwepfungwa kwenguva refu kana kurwara. Ingram naHageman (2003) nhoroondo, "Mamwe mapepa akabudiswa anorondedzera kuonekwa kwezviratidzo zvepfungwa nemararicosteroid kushandiswa." Kunyange zvazvo nzira yacho isingazivikanwi, mhinduro yacho inowanzoshandurwa nekodzero yekurasi kana kuregera kwe corticosteroid. zvakaitwa, zvakajairika kurapwa zvinosanganisira mishonga yekurapa. " Tsvakurudzo yeBuz et al (2004) inoratidzawo kuti dzimwe shanduko dzakataurwa mu hippocampus dzinogona kudziviswa ne "kusarudza antidepressant uye anticonvulsant mishonga yezvirwere." Ava vatsvakurudzi vakaongorora kushandiswa kwe lithiamu munharaunda iyi uye vakaona kuti kupora kwenguva refu ne lithiamu kunogona kuchengetedza hippocampus zvakare. Kuenderera mberi kweiyo tsvakurudzo mune ramangwana inobata chivimbiso chekunzwisisa zviri nani zvose steroid-induced psychiatric effect uye inogadzirisa kushanda kwezvinodhaka mukurapa bipolar disorder.
> Sources
> Cortlandt Forum. Iko bipolar varwere vari pangozi yakakura ne steroid?
> Ingram, DG, &. Hagemann, TM (2003). Promethazine kurapa steroid-induced psychosis mumwana. The Annals of Pharmacotherapy. Dec 01: 37: 1036-1039.
> Markowitz, JS, Carson, WH, & Jackson, CW Zvingaita > dihydroepiandrosterone > -nduced mania. Biological Psychiatry, 45, 241-242.
> PDR Medical Dictionary. Baltimore, Maryland: Lippincott Williams & Williams. 2000.
> Perry, Paul, > Ph.D >, BCPP, uye Brian C. Lund, Pharm.D. "Steroid-Inokonzerwa Nokusawirirana Kwepfungwa." (Yakarongwa 2004).
> Wood, GE, Young, LT, Reagan, LP, Chen, B., & McEwen, BS "Kutarisana nemafungiro emakemikari mumagetsi: Kudzivirirwa nemishonga ye lithiamu." Proceedings ye National Academy of Science yeUnited States yeAmerica. Mar 04: 101: 3973-3978.