Chronic Cocaine Use Rinogona Kukonzera Kuchinja muBongo
Vakawanda venguva refu vanoshandisa cocaine vanotambura nokuora mwoyo. Izvo zviyero zvekuora mwoyo zvinorondedzerwa mukusingaperi kwekodhaine vanoshungurudza zvakanyanya zvikuru kudarika kune vanhu vakawanda.
Kuedza kuziva chikonzero nei vashandisi veCocaine vanonzwa kuora mwoyo uye zvimwe zvinetso, masayendisiti anofunga kuti yakabatanidzwa nekukuvadza kunoitwa nemishonga kune masero europi anoita kuti vashandi vanzwe vakasimudza pavanoita cocaine.
Kukuvadza kana kuuraya masero europi anobatsira musikana kunzwa kufara angakonzera kuwanda kwemaitiro ekudengenyeka pakati pevasingaperi vanokanganisa cocaine , vatsvakurudzi vakati.
Dopamine Neurons Akavhunduswa
Apo cocaine inoshandiswa inowedzera huwandu hweDopamine muuropi, huchiita yakakwirira iyo vashandi vanonzwa, asi kushandiswa kwenguva refu kwechirwere kunoderedza dopamine mazinga, zvichiita kuti zvive zvakaoma kumushandi kuti ave nemanzwiro akanaka.
"Ichi ndicho uchapupu hunonyatsojeka kuti uone kuti inonzi neurons cocaine inopindirana uye isingaifariri uye inodzvinyirirwa nemigumisiro yemishonga," anodaro Karley Little, MD, muongorori wepurofesa wepfungwa paYunivhesiti yeMichigan Medical School uye mukuru we Ann Arbor Veterans Affairs Medical Center Akanaka Neuropharmacology Laboratory. "Mibvunzo yatinosangana nayo ndeyokuti: Masero anogara kana kuti akaparara, ndeyekugadziriswa kana kusingaperi, uye zvinodzivirirwa here?"
Yenguva Dzakanyanya Kokaine Ushumiri Vakadzidza
Vechidiki uye vashandi vakadzidza zvidzidzo zvehuputi zvisikwa zvakawanikwa munguva yekutsvaga kwevashandisi 35 venguva refu yekushandisa cocaine uye 35 vasiri vashandisi. Vakatsvaga tissue ye dopamine uye protein yeVMAT2, iyo inowanikwa mune dopamine vatengesi.
Urini kana sarum samples zvakare dzakaongororwa nokuda kwekocaine, opioid, antidipressants, uye antipsychotic.
Munhu ari pedyo nemunhu mumwe nomumwe akabvunzurudzwa pamusoro pekushandisa zvinodhaka kweumwe munhu, kudhakwa, uye zviratidzo zveunhu uye hutano hwepfungwa.
Inotsanangura Cocaine Kuchengetedza Zviratidzo
Vatsvakurudzi vakawana kuti vashandisi veCocaine vaiva nehuwandu hwakanyanya hwe dopamine neVMAT2 muhupenzi hwavo kupfuura ivo vasiri vashandisi. Uyezve, vashandisi veCocaine vane chirwere chekuora mwoyo vaiva nezvikamu zvishoma zveVMAT2 kupfuura avo vasina kuora mwoyo.
"Nhoroondo yedu inopa hutano hwakanaka hwehupenyu hwekodhaine kuregererwa kwezviratidzo. Mabhuku aripo anoratidza kuti munhu anoshungurudzika wekhocaine achange aine matambudziko akawanda kuchengetedza mhuri nebasa, nguva yakaoma kuregera, inowanzosiya kurapwa, uye zvinowanzoita kuzviuraya, "akadaro Little.
Cocaine Inoshandura Bongo
Vaduku uye vaaishanda vakanga vasina chokwadi kana dopamine masero akanga aparadzwa kana kuti akangoshandiswa nekocaine, uye kana kuchinja kwakadaro kwaigona kuchinjwa.
"Tingave tichiona mugumisiro wekuedza kweuropi kutonga dopamine system mukupindura kushandisa kocaine, kuedza kuderedza kuwanda kweiyo dopamine yakasunungurwa nekuderedza kukwanisa kuiunganidza mumasvingo," akadaro Little. "Asi isu tinogonawo kuona kuora kwechokwadi kana kufa kune dopamine neurons .
Chero nzira, izvi zvinoratidzira fragility yee neuroni idzi uye zvinoratidza utsinye hunoshandiswa necocaine kushandiswa. "
Zvimwezve kuedza pakutsanangura zvinokanganisa zvinokonzerwa nekodineine mumasero europi zvinogona kubatsira mukugadzirwa kwekugadzirisa kwakanaka kwerapa uye pharmacotherapies, vatsvakurudzi vakaratidza.
Kudzidza kwakabhadharwa mune chikamu neNational Institute on Drug Abuse.
Sources:
Little, KY, et al. "Kurasikirwa kweStriatal Vesicular Monoamine Transporter Protein (VMAT2) muHuman Cocaine Users." American Journal of Psychiatry January 2003
Milne, D. "Cocaine Inowanikwa neDamage Brain's Dopamine Neurons." Psychiatric News February 2003