Mishonga inogamuchirwa kurapa kushungurudzwa kwepachirwere kune vanorwara nekenza inogona kubatsira zvakaoma zvikuru-kubata-doro zvinoderedza kunwa kwavo nekuderedza kuda kwavo doro, asi hazvigone kuwanika mumatare akakodzera ekudhakwa kudhakwa.
Rimwe remapoka evanhu vanomwa dambudziko izvo zvakaoma kugadzirisa zvakanaka ndeavo vanozivikanwa sevanotanga kusvika kune vakadhakwa - avo vanoita doro vanoshandisa zvinetso vasati vasvika makore 25.
Iri boka rinofungidzirwa kuva nehupenyu hwehupenyu hwekudhakwa, uye ine mhuri yakasimba yekushungurudza doro.
Kutanga-kutanga kunwa doro kazhinji kunopesana nemaitiro ekurapa oga, zvichida nokuti vane kusawirirana pakati pemakemikari maviri "vatumwa" muuropi, serotonin, uye dopamine. Uku kusaenzana kunotendwa nevasayendisiti kugadzira chido chodhakwa.
Nhamba Yakawanda Yokudzoka Pakutanga-Isa Doro
Pane hutsvakurudzo hwakawanda hunoratidza serotonin kudzvinyirira pakati pekutanga-kutanga doro.
Kutanga-kutanga kunwa doro kune "mhuri yakakura yekushungurudza doro, yakawedzera kuwedzera kwehutsika hwevanhu, uye chirwere chinogadzikana uye chakanyanya kupfuura avo vane chirwere chekudhakwa kwekupedzisira," maererano neNational Institute on Alcohol Abuse and Alcoholism.
Mavambo ekutanga-doro anonyanya kunwa doro hazvisi kubatsirwa nekupa mazano, kuratidza kupesana kwehutano hwevanhu uye kuva nehuwandu hwezvekuita zvakare kana vachiedza kurega kunwa.
Kutsvaga Mafarirwo Anogadziriswa
Nemhaka yekuti boka iri hariti kupindura zvakanaka kurapwa kwetsika chete, vatsvakurudzi vave vachitsvaga mishonga yekurapa kusagadzikana kwemakemikari avo.
Imwe yemishonga inowanikwa kakawanda kuderedza kunhuva kune vanodhakwa avo vanowanzogadziriswa kunodhakwa ndeye ondansetron, mushonga waDAA unogamuchirwa kuti ushandise kurapa kunyorera mune varwere vekenza.
Inotengeswa pasi pezita rechiratidzo Zofran.
Zvidzidzo zvakasiyana nemapoka ekutanga-kutanga madhakwa akabatwa neboka rimwe ne ondansetron uye boka rinodzora rine placebo vakaona kuti mishonga inobatsira kuderedza doro ravo rekudhakwa.
Ondansetron Inoderedza Kuda, Kunwa Mazuva
Chidzidzo paYunivhesiti yeTexas Health Science Centre muSan Antonio yevamwe 271 varwere vakaonekwa sevanokurumidza-kunwa doro vakawana kuti madhawiti e ondansetron pamusoro pevhiki gumi nemana yakaguma nekunwa zviduku pazuva uye mazuva akawanda vasina kunwa zvachose, zvichienzaniswa ne kudzora boka.
Chimwe chidzidzo chakafananidza kuti zvakajeka sei kuti chirongwa chepadhesetron chichiita kuti chido chinenge chichigadziriswa kune avo vanozivikanwa sevanonoka-vanotanga doro - avo vakashandisa doro kushandisa kushungurudza pashure pezera remakore 25. Ondansetron yakabudisa zvakanyanya kuderedza mukuda muboka rekutanga-kutanga, asi kwete kunonoka-kutanga doro.
Zvinodhaka Zvinogadzirisa Dopamine System
Zvinodhaka zvinongorodza basa reropi re dopamine system kuburikidza nemigwagwa yeveurural yakaratidzwa mune zvidzidzo zvekare kuti uchinje maitiro ekunwa. Iyi mishonga inosanganisira ondansetron, naltrexone , topiramate , uye baclofen.
Chimwe chekudzidza kwevhiki masere chakawana kuti kuunganidza ondansetron uye naltrexone zvakanyanya kuderedza kunwa doro mumapoka akafungidzirwa, zvichienzaniswa neutongi hwe placebo.
Zvishomanana Maitiro Akaita NaOndansetron
Zvese zvidzidzo zveeddansetron dzakawana kuti chero migumisiro yemigumisiro yemishonga ine unyoro. Iyo migumisiro yakaipa inowanzotaurwa kuti yaiva kuvhiringidzika, misoro, uye sedation.
Zvisinei, chimwe chematambudziko ekurapa zvinodhaka ne ondansetron ndechokuti chiyero chemishonga inoshandiswa mune zvese zvidzidzo zvekliniki yaive shoma kudarika kuyerwa kunoshandiswa kurapa chirwere chetsva muvanorwara chekenza.
Kwete Kutengeserana Kunowanikwa neAlcoholism Treatment
Mishonga haisi yekutengeserana inowanika mune zverapautic treatment dose yekudhakwa, asi inowanika chete, kunze kwekutsvakurudza zvirongwa zvekutsvaga, mumutero wepamusoro yekurapa chemotherapy-induced nausea.
Chimwe chidzidzo chakatsvaga kuziva kana chirwere chinoshandiswa pakurapa tsvina chichishanda pakurapa doro asi hachina kubudirira. Vatsvakurudzi vakapedzisa vachiti: "Zvinoratidzika kuti muyero wakakwana wokurapa udhakwa haufaniri kutsunga."
Munguva iyi, FDA Inobvumira Campral
Kunyange zvazvo tsvakurudzo inoratidza kuti ondansetron inoshanda mushonga unobatsira kwekutanga-kutanga kudhakwa kwave kwakataurwa kwemakore, zvichiri kushaya FDA kubvumirana nokuda kwechiratidzo ichi. Panguva ino, mushonga weCrazil wakagamuchirwa neRDA kuti ubate utsotsi kuburikidza nekudzikisa kuda.
Neydansetron iyo yave iri pamusika kwenguva yakakwana zvokuti ikozvino inowanikwa muhuwandu hwemagetsi, zvichida haisi kuzova mari inokwanisika kune mugadziri kutsvaga kubvumirwa kweropa rezasi rekurapa dambudziko rekushandisa doro.
Ait-Daaoud, N. et al. "Kubatanidza ondansetron uye naltrexone kunoderedza kushuva pakati pezvinhu zvinokonzerwa nehutachiona hwakagadziriswa: kutanga kwechipatara uchapupu." Psychopharmacology February 2001
Bankle, AJ, et al "Mishonga Kuchengetedzwa Kwemarudzi Akawanda Okunwa Doro." American Journal of Psychiatry June 2010
Caorrea Filho, JM, uye al "Muchikoro chekudzidza chizere-dose ondansetron kuti vabate varume vane simba-kunwa vachibva kunwa doro muBrazil." Addictive Behavior April 2013
Johnson, BA, et al. "Ondansetron inoderedza kushuva kwezvinokonzerwa nezvinokonzerwa nezvinokonzerwa nehupenyu." Psychopharmacology April 2002