Mishonga iye zvino inoshandiswa kurapa kemheyo uye migraines yakaratidzawo kuti inoshanda pakuderedza kunwa doro uye kubata chirwere checocaine. Asi topiramate haigoni kubvuma kugamuchirwa kwekudhakwa nekuda kwehupfumi.
Kwemakore anenge gumi, zvidzidzo zvekutsvakurudza zvakaratidza kuti topiramate, inotengeswa seTramax, inoshanda mukurapa doro .
Muna 2003, chidzidzo cheSouth Science Center Center cheSouth Texas Addiction Research & Technology (START) Centre chakawana kuti avo vainge vachiri vanwiwa zvinodhaka kazhinji kacho kazhinji kacho kuti varambe vakagadzirisa mwedzi, vachienzaniswa neboka re placebo.
Kubudirira pakucheka
Mune chidzidzo chekutsvaga gore rakatevera, vatsvakurudzi ve START START, vakatungamirirwa naDkt. Bankole A. Johnson, vakaita "uchapupu-hwe-gwara rekuongorora kliniki" iyo yakagumisa kuti topiramate ine simba guru pakunwa kudarika naltrexone uye acamprosate , mishonga miviri inobvumirwa kuti iite zvekudhakwa. Zvimwe zvidzidzo zvitsva zvakaratidza kuti topiramate inoshanda zvakanyanya mukuderedza mari iyo vanonwa doro vanodha kupfuura zvinenge zvichiita kubvisa zvakakwana kune vanonwa doro-vanodhakwa.
Kugadziriswa Kushandiswa Kwakakwana
Mutsika, chinangwa chekurapa kwekusvuta kwekushandisa doro ndechekuita kuti urege kuzvidzora, asi mumakore achangopfuura pane zvakanyanya kufunga nezvekuderedza kukuvadza kana kuderedza kuwanda kwedoro rinodhakwa nevarwere kana kuderedza kuwanda kwemazuva ekunwa.
Maererano nekutsvakurudza, topiramate yakawanikwa ichibudirira mukuderedza kushandiswa kwedoro zvakanyanya kupfuura ikozvino inogamuchirwa mishonga disulfiram, naltrexone, uye acamprosate.
Funga nezvekuderedza kuipa
Kuongorora kwechangobva kuitika kwekudhakwa kwechidharo muVeterans Health Administration yakawana kuti VA
vanachiremba vakanga vachinyora topiramate nokuda kwevarwere vavo vanodhaka-doro pamwero wakakwirira kupfuura naltrexone uye acamprosate pamwe chete.
Kushandiswa kwechirwere ichi hachisi kuongororwa neAV nokuti haibvumirwi kushandiswa sekushandisa doro kushandiswa kwemishonga, asi izvo hazvina kurega vanachiremba kuti vazvinyora apo chinangwa chekurapa chakanga chiri kuderedza kukuvadza kwekuwedzerwa kunwa doro.
Vanyori veV VA vakaongorora kuti kushandiswa kwe-topiramate pamusoro pemimwe mishonga kunoratidza kuchinja kwekurapa kudhakwa kwekudhakwa kunopera kuderedzwa kwezvinodhaka, panzvimbo pokudzivisa zvachose.
Topiramate Inobudirira yeKocaine Inodhaka
Kunyanya ichangopfuura, tsvakurudzo yakawana kuti topiramate inobatsirawo pakurapa cocaine kuwedzerwa . Bhuku reUniversity of Maryland Chikoro cheMishonga chevanhu vakuru 142 vakanga vachitsvaga kurapwa kwekodhaine vakawana kuti topiramate yakawedzera nhamba yekocaine isingaiti mazuva.
Pakupedzisira, zvidzidzo zvakawana kuti topiramate inogona kubatsira kuderedza kushandiswa kwemishonga nevashandisi vakanga vasina kutsvaga kurapwa kwekodhaine. Inoshanda kuburikidza nehutano hwehuropi hunoita sei kune cocaine, nokudaro nekuderedza kushuva kwechirwere.
Topiramate ndiyo mishonga inotanga kuwanika inoshanda mukurapa kukanganisa kwekodineine, maererano nevanyori vekudzidza.
Chimwe chidzidzo chakaratidza kuti chinobudirira mukurega kusvuta .
Topiramate Hapana Chengetedza Chirairo Chekuchengetedza Chidzivirirwa
Kunyange zvazvo tsvakurudzo inoratidza kuti topiramate inoshanda kwazvo, inotaura, pakuderedza kunwa kunodhaka uye mukurapa kukodhakwa kwekodineine, mushonga haugone kushandiswa pakuzara kwawo. Nemhaka yokuti haibvumirwi neU.S. Food and Drug Administration zvakananga nokuda kwekurapa zvinodhaka, makambani einishuwarenzi haagoni kubhadhara mitemo yevaya vanoshandisa.
Uyezve, nokuti topiramate haisisina kudzivirirwa nekutengeserana, uye, saka, yakazarurirwa kugadzirwa kwezvinhu, haisi mari inokwanisika kumakambani emishonga yekutsvaga mari inodhura yakadikanwa kuwana FDA mvumo yekushandisa zvinodhaka kushandiswa kwemishonga.
Chero mishonga yemishonga yekudhakwa kana kudhakwa kwaizova nzira isingadhura iyo inopinda chirongwa chekurapwa kwekugara, asi pasina inshuwarisi inobatanidzwa, topiramate ingada kudhura kupfuura mamwe mishonga yaDA-inogamuchirwa.
Kunyange zvazvo topiramate isiri FDA yakagamuchirwa mukurapa doro nekudhakwa, hapana chinorambidzwa kune vanopa utano hwehutano vachitsanangura mishonga nokuda kwezvinangwa izvi.
Sources:
Del Re, AC, et al "Chirongwa che topiramate kupedza zvinetso zvekushandisa doro muVeterans Health Administration." Addiction Science & Clinical Practice 8 July 2013
Fran, J, et al "Pharmacotherapy Doro Kudzora: Mamiriro Ezvinhu Zvokurapa Mazvino." Ikozvino Maonero muNeurobiology . 23 August 2013.
Johnson, BA, et al, "Topiramate for the Treatment of Cocaine Addiction." JAMA Psychiatry . 16 Oktober 2013.
Kampman KM, et al. "Chirwere Chiviri-Chirema, Chebhendi-Chidzorwa CheTriramate Kurapa kweComorbid Cocaine uye Doro Kubvuma." Zvinodhaka uye Doro Kubvuma 1 November 2013.
Oncken C, et al. "Topiramate yekurega kusvuta: A Randomized, Placebo-Controled, Pilot Study." Nhamba yeNicotine uye Fodya 21 September 2013.