Kunovandudza Mazuva Ekurapa Kwokurasikirwa
Mishonga naltrexone yava imwe yemishonga inoshandisika inoshandiswa pakurapa nokuda kwekudhakwa kwepabonde nokuti inoshanda kuderedza makemikari zvinokonzerwa nedoro muuropi.
Imwe yemishonga mitatu chete yakagamuchirwa kurapwa kunwa doro, naltrexone yakashandiswa kwemakore kubatsira vanhu vakatorega kunwa kuti vasadzoke zvakare.
Naltrexone yave ichishanda pakurapa vanhu vakave vakapindwa muropa nemishonga inonzi opioids, heroin uye vari kuongororwa mumagariro ekushandiswa kwecocaine . Izvo zvinodaro kuburikidza nekuvhara maitiro ayo opioid ane pane nzvimbo dzinofadza dzeuropi. Naltrexone inoderedza doses inoshandiswawo kurapa marwadzo anokonzerwa nemamiriro ezvinhu se fibromyalgia uye asingagumi kuneta.
Zvinetso NepaPiritsi Chezuva Rega
Nokuda kwekurapwa kwezvinodhaka kushandiswa kwewaini , naltrexone pakutanga yakarongerwa sepiritsi yezuva nezuva inowanzotorwa masvondo gumi nemaviri, uye naltrexone mufomu yepiritsi - inotengeswa seRevia neDepade-ichiri kushandiswa zvikuru.
Zvisinei, pane dambudziko rehupenyu nehupiritsi ye naltrexone - kuti iite basa, vanhu vakagadzirirwa kubatsira vanofanira kutora mishonga zuva rega rega. Kune avo vanonetseka nemigumisiro yekudhakwa kunwa doro nekudhakwa kushandiswa kwezvinodhaka , kutevera kutora chirwere chezuva nezuva kunogona kuoma.
Kubata-Kubata, Kamwe-kamwe-Mwedzi Injection
Dambudziko iri rakarondedzerwa apo vatsvakurudzi vakatanga kutarisa imwe nzira itsva ye naltrexone inogona kujowa kamwechete uye inononoka kusunungurwa mumutambo kwemwedzi.
Chimwe chezvidzidzo izvi chakaitwa kuYunivhesiti yeNorth Carolina kuChapel Hill uye chaibatanidza 624 varwere vakanga vari kurapwa nekudhakwa kwewaini muzvipatara, VA
makiriniki uye zvipatara muUnited States.
Vose varwere vakanga vachishingaira kunwa, asi vachirasikirwa nekudhakwa.
Kuderedza Mazuva Akanyanya Kunwa
Vakatora vakajowa ne 380 mg. yekare-acting naltrexone, 190 mg. ye naltrexone, kana kupa injwe ye placebo. Majekesheni aipiwa mwedzi uye mapoka ose maviri akagamuchira zvishoma zvishoma zvekugadzikana kwepfungwa dzepfungwa.
Chidzidzo chacho chakawana kuti 380 mg muyero we naltrexone wakaguma nekuderedzwa kwe 25% kwemazuva ekunwa doro, asi 190 mg muyero wakaderedza kusvuta kwemazuva 17%.
Vatsvakurudzi vakafunga kuti varume vakagamuchira naltrexone kurapwa kupfuura vakadzi uye kuti varwere ivavo vakapinda muchidzidzo nenguva isina nguva vakaona kurapwa kwakanyanya.
Zvimwe Zvikamu Zvakaoma, Asi Zvinyoro
Kubva kune avo vanotora chirwere che 380-mg, 14.1% vakadzingwa kubva mukurapa pamusana pemigumisiro yemigumisiro, kusanganisira kusuruvara, kuora musoro uye kuneta. Chete 6.7% yeboka rinogamuchira 190 mg rakaramba kurapwa nemhaka yemigumisiro yakaipa.
Iko North Carolina kudzidza ndiyo imwe yematambudziko makuru ezvidzidzo zvakabatwa nemishonga yekudhakwa nedoro. Mhedziso yevatsvakurudzi ndeyekuti nguva refu yakasunungurwa naltrexone yakanyatsorambidzwa uye yakaderedza zvakanyanya kunwa doro mukunyatsomwa vanorwara.
Vivitrol Yakagamuchirwa neDDA
Chidzidzo chacho chakawanawo kuti nguva yakareba yekuita ye naltrexone inogona kuvandudza maitiro ekurapwa kune vakadhakwa nekubvisa mishonga yekuteerera mhirizhonga uye kupa "inofanirwa kushandiswa kwemishonga inoshandiswa pakurapa."
Chidzidzo ichi uye vamwe chaive chikonzero muhutori hweUnited States neDrug Administration munaApril 2006 kuti vabvumirwe kurapwa kwegore-imwe-month naltrexone-inotengeswa seVivitrol - yekushandiswa semushonga wekudhakwa kwewaini.
Sources:
Garbutt, JC, et al. "Randedzed Tried Trial Trial Of Long-acting Injectable Naltrexone for Alcohol Dependence." Nyaya yeAmerican Medical Association April 2005
US National Library of Medicine. "Naltrexone Injection Injection Mishonga, Herbs uye Zvimwewo