Inodzora Doro-Kutsvaka Maitiro uye Kunzwisisa
Vatsvakurudzi vakabatana nepuroteni inowanikwa muuropi kune zvose zvinodhaka kutsvaga doro uye kunzwisiswa nemigumisiro yekudhakwa doro .
Vatsvakurudzi veYunivhesiti yeWashington vanorayira humwe uchapupu hwakananga mumakonzo kuti zviratidzo zveprotein kinase A (PKA) zvinodzora zvose zvinodhaka kutsvaira doro uye kunzwisisa kune mamwe emigumisiro yekudhakwa kunodhakwa, maererano neNational Institute on Alcohol Abuse and Alcoholism.
Mhinduro Yakachinjwa
Zvichipiwa sarudzo pakati pemvura uye mhinduro dzinenge doro, mice inoshaya RIIB subunit yePKA yakasarudza doro rekudhakwa pamasimba ayo akakwirira. Mukuwedzera, chigunha chekugadzirisa mapepa maitiro akanga asina kunyanya kufanana neavo vane PKA chaiyo kune zvinodhaka zvinodhaka.
Puroteni inobatanidzwa mukutaurirana kwepisracellular, PKA iripo muuropi yose. PKA phosphorylates yakawanda yeprotein intracellular uye inoronga mazita emagetsi, nokudaro ichichinja magetsi emasero uye, zvichida, masero ekushanda nekukurukurirana pakati peeurons.
Mice dzinoshayikwa RIIB, imwe yemasereji matanhatu anokonzera PKA, ane ruzivo rwekuchinja kwebasa rePKA, chiitiko ivo vanotsvakurudza vanotenda kuti vanochinja maitiro avo kumishonga ekurapa kwewaini.
Kudzora Kudha Doro
"Kutanga kutsvakurudza mune zvematongerwo emasvomisitiri nemhuka zvakaratidza kuti doro rinoshandiswa rinokonzera PKA basa," akadaro Enoch Gordis, MD, Mutungamiriri weNIAAA, uyo akapa rubatsiro rwekutanga rwekudzidza.
"Chii chiri chitsva pamusoro pebasa iri ndechokuti - izvo, kunyanya mumufananidzo wemhuka, PKA inogona kutarisira doro kushandiswa uye zvimwe zvinodhaka zvinodhaka."
Todd Thiele, Ph.D., Department of Psychology uye Doro uye Drug Abuse Institute, Yunivhesiti yeWashington, nevamwe vake vakaongorora mufambiro wokunwa mumashamba gumi nemaviri uye mhando 12 dzekugogodza pamwe nekuchinja mutauro weRIIb wePKA.
Kunyange zvazvo kusawirirana kwakawanikwa pakati pemapoka maviri mukunakidzwa kunotapira zvinogadzirisa zvinotapira kana zvinorwadza, mbeve nePKA mutation inonwa kaviri kana makumi maviri-20 muzana doro remvura semhashu yakasvibirira.
Sedative Effects
Vatsvakurudzi vakaonawo nguva inodikanwa yezvinodhaka zvinodhakwa kuti vadzorezve kukodzera. Vakayira mapoka ose emakonzo nedoro uye vakaisa pamasana avo mumapurasitiki akafanana neU. Kukohwa mice kwakawana zvakakurumidza kubva pane zvinokonzerwa newaini, kudzokerazve shure shure kwemaminitsi 65 zvichienzaniswa nemaminitsi makumi mapfumbamwe emakonzo.
"Zvichida mapeji ane RIIB mutation anonwa zvakanyanya ethanol nokuti PKA basa rinovhiringidzika muuropi dzenharaunda dzinobatanidzwa mukugadzirisa muganhu weEthanol," akadaro Dr. Thiele. "Zvino zvinokosha kuziva kuti muuropi nzvimbo dzipi dzeRIIB dzinobereka izvi."
> Sources:
> Thiele, TE, et al. "High Ethanol Consumption uye Low Sensibility kuEthanol-Induced Sedation muProtein Kinase A-Mutant Mice." Nyaya yeNeuroscience May 2000