Zvinodhaka Zvinoshandiswa Sezviri Kukwegura 17
Kuongororwa kwemashure makumi matatu nemazana makumi mana (34) vechidiki avo vakafa vachiri vaduku vakapa vatsvakurudzi zvishoma kuti vasaona kukanganisa kushandiswa kwechirwere chezvinodhaka kunogona kuita kune ubongo hwevashandisi.
Mune chidzidzo chakabudiswa muNeuropathology uye Applied Neurobiology, vatsvakurudzi vakaongorora ubongo hwe heroin 34 uye vanoshandisa methadone vakafa pamusikana wemakore makumi maviri nemaviri.
Vamwe vavo vakafa pa17. Vakafananidza uropi hwavo kune uhu hwevanhu vechiduku 16 vakafa vaduku asi vakanga vasingashandisi zvinodhaka.
Kuongororwa kwakawana kuti vashandisi vezvinodhaka vakanga vanowedzera katatu kuti vauye nehupombwe kune avo vasingashandisi zvinodhaka. Vashandi vechidiki vanoshandisa zvinodhaka vakaonekwa zvakafanana neyevanhu vakawanda vakwegura uye kukanganisa kwakafanana nemunhu ane chirwere cheAlzheimer.
Dambudziko reNerve Cells muVashandisi Vezvinodhaka
Masayendisiti paYunivhesiti yeEdinburgh akadzidza ubongo hwomunhu akafa akabatwa zvinodhaka zve heroin uye methadone uye akazvifananidza nehuchenjeri hwevechidiki vasiri vashandisi vezvinodhaka.
Izvo zvinokonzerwa nemasero emasero zvakanga zviri munzvimbo dzeuropi dzakabatanidzwa mukudzidza, kuyeuka, uye kunyatsogadzikana mupfungwa, uye zvakanga zvakafanana nekuparara kunowanikwa mukutanga kwechirwere cheAlzheimer.
"Kudzidza kwedu kunoratidza uchapupu hwehuwandu hunowedzera hwekuora kwehuropi hunosangana ne heroin uye methadone yekushandisa, iyo inogona kuva yakakwirira pane vechidiki apo vanhu vanogona kuwana tsika yacho," akadaro munyori wenyanzvi Jeanne Bell Purofesa weNeuropathology.
"Takaona kuti uroyi hwevaya vaduku vanoshandisa zvinodhaka hwakaratidza huwandu hwakakosha hwepuroteni mbiri dzakabatana nehutano hwehupi."
"Pataidzidza, takaona kuti kushandiswa kwezvinodhaka kunokonzera kushanduka kwekwenyoro muuropi. Kutorwa pamwechete, zvidzidzo zviviri zvinoratidza kuti kushandiswa kwemaawa kusinganzwisisiki kungave kwakabatana nekukwegura kusati kwakura kweuropi," Bell akataura.
Heroin uye Methadone Chikonzero Kukuvara
Ivhareji yemakore mumapoka maviri aya muchidzidzo chacho yaive nemakore makumi maviri nemasere uye yakabatanidza vamwe vanoshandisa zvinodhaka sevana vaduku se17.
"Tau protein, iyo inogadzikana kwayo inokosha pakukurukurirana uye kutakura mukati memasero europi, yakanga isina kusvibiswa mune mamwe masero, ichikonzera kushungurudzika kwemasero cell uye rufu munzvimbo dzakasarudzwa dzeuropi," vakanyori vakadaro. "Mamwe masero emasero akaratidza kuunganidza kweproyroid proyroid protein, iyo inoratidza kuti mapuroteni ekutakura ainge avhiringidzika uye masero esimba anoshanda."
Mvura Yakasimba Inokuvadza
"Chidzidzo ichi chinoratidza kuti kushandiswa kwezvinodhaka kunogona kutungamirira pakuvaka-up kwepuroteni inokonzera kushungurudzika kwemasero masero nekufa muzvikamu zvinokosha zveuropi.Iyo inonetseka zvikuru sezvo pane zviratidzo zvakasimba zvekushandisa zvinodhaka, kunyanya opiates se heroin uye methadone, yakaramba ichikwira mumakore achangopfuura , "anodaro Purofesa Bell.
"Vashandisi vezvinodhaka vatakatarisa muzvidzidzo zvakasuruvarisa vakafa pazera remakore, asi kune vamwe vakawanda vasingaoni migumisiro yakareba iyo mishonga iyi ingave ichikonzera."