Wellbutrin - anozivikanwawo nezita rawo, bupropion - inonzi antidepressant iyo dzimwe nguva inoshandiswa kurapa kuora mwoyo mu bipolar disorder. Bupropion's manufacturer anotengesa mushonga uyu pasi pezita rechitatu, zvakare: Zyban, chirwere chinotengeswa kubatsira vanhu kuti varege kusvuta.
Mishonga inowanikwa munguva pfupi yakasunungurwa (75 uye 100 mg mahwendefa) uye kusunungurwa kusununguka (100 uye 150 mg) mavara (anotengeswa se Wellbutrin SR®).
Hazvisi pachena nei Wellbutrin inoshanda kuderedza zviratidzo zvekuora mwoyo . Chemhemikisi, haisi yakabatana kune chero ipi zvayo yakakura yekurwisana nayo. Zvisinei, zvidzidzo zvinoratidza kuti zvinoshanda, uye zvinogona kuva nezvimwe zvinobatsira pamusoro pevamwe vanodzvinyirira pakurapa kuora mwoyo kune vanhu vane bipolar disorder.
Wellbutrin muBipolar Disorder
Anodzvinyirira , kusanganisira Wellbutrin, anoshandiswa zvakanyanya muhutano hwebipolar, kunyange zvazvo pasina humwe humwe uchapupu hwekuchengetedza kwavo uye rubatsiro. Zvishoma zvakagadzirwa zvakanaka, zvidzidzo zvechiremba zvekugara kwenguva refu zvakaitwa, uye hazvisi pachena zvakajeka kuti zvinokonzera sei zvinodhaka zvinogona kuwirirana nemafungiro emagariro anowanzopiwa kune avo vane bipolar disorder.
Chimwe chekudzidza kwevhiki-gumi chakaratidzira Wellbutrin akabatsira vanenge hafu yevanhu vane bipolar disorder avo vairapwa nemishonga pamwe chete vachitora mafungiro emagetsi.
Pazvinorondedzera vanodzvinyirirwa nevanorwara neBipolar, vanachiremba vanonyanya kunetseka nezve "mafungiro ekuchinja," iyo apo kuora mwoyo kunoshanduka kamwe kamwe kuine mania, hypomania kana kuti yakavhengana.
Kune humwe humwe uchapupu hwokuti Wellbutrin inogona kuva nemadhura maduku e "manic switch" kana ichienzaniswa nemamwe marudzi evanhu vanorwisa zvinodhaka, zvakadai sevakwegura tricyclic vanodzvinyirira uye norepinephrine-serotonin reuptake inhibitors (SNRIs). Vanenge 10 muzana yevarwere mumusangano wevhiki gumi vakaona kuwedzera kukuru kwezviratidzo zvavo zvevanhu, vachienzanisa ne29% kune avo vanotora SNRI.
Maitiro ekuchinja anoita seanoitika kakawanda kune vanhu vane bipolar I vanotora antidepressants. Nokudaro, nyanzvi dzinokurudzira kuti bipolar I varwere vanongorayirwa zvinodzvinyirira pamwe chete nemafungiro ekusimudzira mishonga.
Kutanga Wellbutrin: General Guidelines
Chiremba wako kazhinji achada kutanga newe Wellbutrin kana Zyban pamwero wepasi uye wowedzera kuwedzerwa kwako, nekuda kwekuda kwemigumisiro .
Paunotanga kutora Wellbutrin, muyero wako wekutanga haufaniri kuva kupfuura 150 mg / zuva. Izvi zvinogona kuwedzerwa kusvika kune 300 mg / zuva pazuva rechina pachinoshandiswa senzira yekurega-kusvuta, uye pakupedzisira kusvika 400 mg (yakasunungurwa kusunungurwa) kana 450 mg (nokukurumidza kusunungurwa) iyo yakashandiswa kurapa kuora mwoyo.
Pakuwedzerwa kwe 400-450 mg / zuva njodzi yako yekukundwa katatu, kunyange zvazvo ichiripo, duku zvikuru: zvina pa1 000 vanhu vanopunzika kubva kune Wellbutrin pane imwe yepamusoro iyi. Varwere vanonzwa kushungurudzika, kusagadzikana kana kusuruvara kunofanira kugara pane imwe nguva yakaderera uye / kana kuwedzerwa kuyerwa zvishoma nezvishoma. Zvinogona kutora vhiki imwechete kana ina kuvarwere vanotora bupropion kuti vanzwe zvakakwana zvikomborero.
Zvizhinji zvinowanzova nemigumisiro yemutachiona zvinosanganisira misoro yemusoro, yakaoma muromo, kuora mwoyo, uye kusuruvara.
Kunyange zvazvo vakawanda vanodzvinyirira vachiita sevanokonzera kana kuti vanoita kuti kuwedzere kuwedzera, Wellbutrin / Zyban inoonekwa se "kuyerwa kwekutakura," uye vanhu vakawanda vanoti vanorema kudarika kuwana uremu pavanotora mishonga.
Kuchenjerera paWenbutrin / Zyban
Heano zvimwe zvinhu zvaunofanira kutarisira paunotora iyi mishonga:
- Chikamu chiduku chevanhu vanoona anorexia pavanotora bupropion, saka varwere vane nhoroondo ye anorexia nervosa kana bulimia , kana vane nhoroondo yekubatwa, haafaniri kutora mishonga iyi. Ichokwadi, mamwe mabhuku anopa kuti Bupropion isatorwa nemunhu wese asingakwanisi kurasikirwa neanopfuura 5% yehutano hwemuviri huripo.
- Kana uri kutora MAOI kuora mwoyo, iwe unofanira kumirira kwemavhiki masviri mushure mekupedzisira mukana wako wemishonga kuti utange Wellbutrin / Zyban.
- Bupropion haina kuzivikanwa kuva nengozi panguva yekudzivirira kana kuyamwisa, asi zvirokwazvo, chiremba wako uye chiremba wevana vanofanira kuziva mishonga yose yauri kutora nguva dzose.
- Kana iwe uchinge warasikirwa neipi, SKIP IT. Ngozi yekubatwa ndeyekudzivirira, uye kuwirirana kunowedzera kukonzera kubatwa.
- Usambozvitora zvose Wellbutrin naZyban. Zvose zvaunenge uchiita zviri kuwedzera kuwedzerwa kune imwe nguva inogona kuipa.
- Kushandiswa - kunyanya kushandisa zvakanyanya - doro kunowedzera mukana wekutora kana uchitora bupropion.
- Kuchengetedza kunofanira kutorwa paunobatanidza Wellbutrin kana Zyban neanticonvulsant mishonga phenytoin (zita rinonzi Dilantin), carbamazepine (zita rinonzi Tegretol) (iro rinowanzoshandiswa kurapa bipolar disorder), kana phenobarbital, kana kuti nechirwere chemishonga cimetidine (zita rinonzi Tagamet ).
Sources:
National Alliance on Mental Illness. Bupropion (Wellbutrin) chokwadi peji.
Pacchiarotti I et al. Sangano reInternational for Bipolar Disorders (ISBD) rinoshanda mushumo rinorondedzera nezvekushandiswa kwezvinorwarisa muBipolar disorders. American Journal of Psychiatry. 2013 Nov; 170 (11): 1249-62.
Post RM et al. Mood inoshandura mu bipolar kuora mwoyo: kufananidza adjunctive venlafaxine, bupropion, uye sertraline. British Journal of Psychiatry. Jul 2006, 189 (2) 124-131.