ADHD Vakwegura paDambudziko Rakawanda Rokunyanyisa Doro
Ndezvakaitika here kuti hafu yevanhu vakuru vanozivisa zviratidzo zvekucherechedza-kusakwana kwehutano hwehutano (ADHD) zvakare inorondedzera kusawirirana kwezvinodhaka zvekushandisa zvinodhaka, kusanganisira kudhakwa?
Pane chimwe chinhu chinowedzera dambudziko kune rimwewo here? Kana kuti kune mamwe maitiro ekubatanidza pakati pekusava nehanya, motokari, kushushikana, uye kudhakwa ? Kana kuti ihwo humwe humwe humwe humwe humwe here?
Vamwe vatsvakurudzi vanotenda kuti vakaona zvakasiyana-siyana zve phenotype kana "purogiramu" yevanhu vane co-existing ADHD uye kudhakwa.
Kunyange zvazvo zvidzidzo zvepakutanga zvakaratidza kuti maitiro ehuwandu hweHDH uye kudhakwa, imwe yunivhesiti yeRugensburg yekudzidza yakashaya ruzivo rwakakosha rwemhando mbiri dzakasarudzwa dzemakemikari, iyo inokurudzira polymorphism ye serotonin transporter gene (5-HTT) uye 5-HT2c mutezo Cys23Ser polymorphism.
Zviratidzo zveHADH uye Doro Rinoshatiswa
"Zvigumisiro zvedu zvinoratidza kuti vanhu vanoramba vachiratidza zviratidzo zveDHD mukukura kunoita sevari pangozi yakawanda yekuita doro-kushandiswa kwechirwere ," akadaro Monika Johann, chiremba uye chikwata chekutsvakurudza paYunivhesiti yeRegensburg uye wokutanga munyori wekudzidza. "Uyezve, kune uchapupu hwekuwedzera kwakanyanya kwekudhakwa kwewaini mune zvidzidzo neAdHD."
Vatsvakurudzi vakatsvaga 314 vakwegura vakuru (262 varume, 52 vakadzi) pamwe ne 220 vasina hutano hwakanaka hwekutonga, zvese zveGerman.
Mumwe nomumwe muboka akaongororwa nezvirwere zvepfungwa, zvakadai sekushandisa-kushandisa-kusanganisira doro), ADHD, uye kusagadzikana kwehutano hwevanhu (APD).
Sources of Genetic Liability
Varwere vane nhoroondo yematambudziko makuru epfungwa, kusanganisira kuora mwoyo uye schizophrenia , uye avo vane zvinodhaka kune zvinodhaka kunze kwewaini uye nicotine havana kubviswa kubva pakutsvakurudza.
Genotyping yakaitwa pasina ruzivo rwehutano hwekuongororwa, nekutarisa kune 5-HTT anokurudzira uye 5-HT2c Cys23Ser polymorphism.
"Prior neuroendocrine dambudziko rinodzidza nemishonga inonzi fenfluramine munyaya dzine ADHD kana kudhakwa kwakaratidza kusiyana kwakafanana mumusana wekutengesa serotonergic kana tichienzaniswa nenyaya dzakanaka," akatsanangura kudaro Johann. "Chiitiko chinowanzoitwa fenfluramine chirongwa ndechekuwedzerwa kunogona kuenzaniswa muprolactin inotenderera.Ukuwedzera uku kwacho kunosanganiswa munyaya dzine ADHD kana kudhakwa." Zvivako zvakakosha zvinoshandiswa fenfluramine-induced prolactin kusunungurwa ndeye 5-HTT uye 5-HT2c receptors Saka, zvose zviri zviviri zvinoratidzika sezvinyorwa sezvinyorwa zvakanyanyisa zvekuberekwa kweAIDS uye kudhakwa. "
Genetic Predisposition Haifaniri Kuwanikwa
Hapana kana iyo, kunyange zvakadaro, inoratidzika seine maitiro ehutachiona hunokonzerwa nemuenzaniso unongororwa. "Nhoroondo yedu inoratidza kuti 5-HTT anokurudzira uye 5-HT2c Cys23Ser polymorphism haibatsiri pakuisa zvinowanzogadzirisa zvirwere zveAdHD uye kudhakwa kwewaini," akadaro Johann. "Zvisinei, mamwe mazita emamwe mazita emagetsi haafaniri kuongororwa."
Kunyange zvakadaro, zvakawanikwa zvinoratidza zvakasiyana-siyana zve phenotype, nzira yekuyera chimiro chinocherechedza kana mufambiro.
Chidzidzo cheRefensburg chakawana kuti vanhu vakwegura vakuru vane ADHD vane huwandu hwekudhakwa kwezuva nezuva zuva rose, makore ekutanga ekutanga kunwa doro , kuwedzera kwemafungiro pamusoro pekuzviuraya, nhamba yakawanda yekutongwa kwematare, uye APD.
Nokudaro, pasinei nekushayikwa kwechirwere chemazuva ano, "data inoratidza zvakare kuti kuva ADHD kunoreva kuva pangozi yakawanda yekuvandudza doro rekudhakwa," akadaro Ema Loncarek, chiremba, uye chiremba mune kliniki yepfungwa University of Regensburg. Loncarek inoshanda padivha nekuda kwemishonga isina kukodzera mishonga yemishonga, kugovera detoxification nekurapa.
ADHD Inoita Zvinonetsa Kuoma
"Zvakawanikwa naDohn Johann zveen phenotype zvakaswedera pedyo nezvatinoona mune zvinodhaka zvinodhaka neAdHD, uye chii chakatsanangurwa kare nevamwe vanyori.Tinoona nguva dzose kuti zvinodhaka zvinodhaka neAdHD zvakaoma kubata. kushandisa zvisina kufanira zvinodhaka mberi kwevamwe vanhu, shanduka kare kune 'zvakaoma' zvinodhaka, kutora nguva refu kuti utange kurapwa, uye kutora nguva yakareba kuti ugone kupedza utachiwana. "
Chidzidzo chacho chakawana kuti mukati meboka iri revadhakwa, zvidzidzo neAdHD mukukura ndezvi:
- Kazhinji kusvika kashanu pane dzimwe nguva kupfuura vanhu vakawanda
- Makore mana ari vaduku pakutanga kudhakwa
- Drank 50 gramu imwe doro pazuva
- Kaviri kacho ingave nemhuri yekare yekushungurudza doro
- Katatu kanopfuura yepamusoro yehutano hwehutano hwevanhu
- Kazhinji kanomwe huwandu hwekuda kutarisana nematare
- Zvinopfuura kaviri kuwanda kwekufunga kuzviuraya
Specialized Treatment Inodiwa
Vose Johann naLoncarek vakataura nezvekudiwa kwekuvandudzwa uye kuongororwa kwezvirongwa zvekurapa zvakanyatsotarisana ne "phenotypical specifics" pamwe nekusawirirana kunovapo-kwakadai sekudhakwa uye ADHD. Kunyange zvazvo zvirongwa zvezvemishonga, izvo zvakaratidza, zvakanyatsoongororwa pakurapa kweHDH muhuduku, kunyatsotarisirwa kwakapiwa kune zvinhu-kushungurudza vanhu vane ADHD mukukura. "
"ADHD inoratidzika kunge yakanyanya kufungidzirwa muhukuru," akadaro Johann, "asi zvinoita sekuti inokosha inokonzera kukanganisa kunwa doro."
Kunobva:
Johann M, et al. Kuda Kunwa Doro Kunovimba Nokufungisisa-Kusagadzikana Kushaya Utano Kugadzikana: Kusiyanisa muPhenotype Nokuwedzera Kuwedzerwa kweDambudziko Dambudziko, asi Kwete muGenotype (Serotonin Transporter uye 5-Hydroxytryptamine-2c Receptor). Kunwa doro: Clinical & Experimental Research . 2003.