Topiramate Inonyanya Kubudirira MuDoro Rekushandisa Matambudziko
Topiramate, mishonga inorwisa-seizure inowanzonyorerwa kune vakwegura vane chirwere, inobatsira zvikuru mukubatsira vanodha-vanovimba vanoramba kunwa. Iyo inobva kune shuga inowanzoitika monosaccharide D-fructose. Zvenguva refu zvidzidzo zvinoratidza zvishoma zvishoma zvinetso zvakakomba zvine chokuita nekutora ichi chirwere kuvanhu vakawanda.
Iyi ndiyo mishonga yokutanga iyo yakaratidza kuti inoshanda kune vanodhakwa zvinodhakwa vachiri kunwa.
Zvimwe "kumisa-kunwa" zvinodhaka ndezvevaya vakatosiya kunwa.
Vanonwa vanowana kunakidzwa nedoro pavanodzinga makemikari dopamine muuropi. Topiramate inoshanda ne "kushambidza" iyo yakawandisa dopamine. Mune mamwe mazwi, vakadhakwa havasati vava kuwana mufaro kana kunwa.
Clinical Evidence for the Alcoholism Pill
Sezvo Topiramate yakatanga kuratidzwa sekurapa kunwa doro zvisina kufanira, tsvakurudzo dzakawanda dzakaitwa kuti dziedze kubudirira kwayo. Inenge imwe neimwe yeiyi yakaratidza kuti mushonga wacho unoshanda kana unovimbisa. Zvisinei, hazvibvumirwi zvakananga neDDA yekurapa doro rekushandisa chirwere.
Semuenzaniso, kumwe kuongorora kwakawana kuti vanonwa zvinodhaka vakange vanowanika katanhatu kuti varambe vaine mwedzi kwemwedzi kana vakabata mishonga, kunyange mudiki. Vatori venzvimbo vachitora placebo kanowanikwa katatu kakawanda kuti vanwe zvikuru panguva yekuedzwa kwekliniki.
Vose makumi mashanu nevatatu vatori vechikamu vakanga vachiri kunwa zvakanyanya vasati vatora Topiramate asi vakanga vachironga kusiya.
Zvimwe zvitsva zvinowanikwa kubva muchidzidzo chechipatori zvinosanganisira:
- Mushure memwedzi mitatu, 24 muzana yeTopiramate boka rakanga risati rarega kwemwedzi umwe. Vane 4 muzana chete muboka re placebo vaiva nemwedzi mumwe wakangwara.
- Muboka reTopiramate, 50 muzana havana kubata mumwedzi wokupedzisira, vachienzanisa ne16 muzana yevaya vanotora placebo.
- 50 muzana yeTopiramate boka rakataura zvido zvishomanana zvewaini, zvichienzanisa ne15 muzana muboka re placebo.
Chimwe chiitiko chekupedzisira chinyorwa chinoratidzika sechichigadzirisa nyaya idzi, zvisinei kuti hazvirevi nematanho akafanana. Izvi zvakatongwa zvinosanganisira vatori vechikamu 371, hafu yaro yakagamuchira topiramate uye imwe hafu ye placebo. Zvakare, topiramate yakaratidza kuti inoshanda kuburikidza nevhiki yechina yekudzidza nehomanana mazuva ekunwa kwakanyanya kunotaurwa pakati peavo vakaitora.
Makomborero eAlcoholism Pill
Topiramate is innovative nokuti inopa rubatsiro rwekurumidza kune vanodhakwa mumatambudziko. Inotangawo mazano matsva ekurapwa kwemishonga ekudhakwa kwekushandisa doro.
Migumisiro yezvidzidzo zvakaitwa kusvikira ikozvino zvinoratidza kuti kunyange kuderera kwemashoko eupiramate ane simba rokunatsiridza kushungurudzika uye kusagadzikana kwemafungiro ekusiya kunwa zvinokonzera. Yakagadzirisawo zvakanyanya pakuvandudza kugadzirisa kuchengetedza uye kuderedza doro rekushandisa .
Zvimwe Zvikamu zveTopiramate
Kunyange zvazvo Topiramate inogona kukubatsira nedambudziko rako rekunwa, unogona kuva nemigumisiro. Nguva dzose zvakakosha kuyeuka kuti munhu wese akasiyana uye uyu haasi mushonga-zvose kune zvose zvinodhakwa.
Pakati pezvinonyanya kukosha kune vanodhakwa kutsvaga kuzviuraya, kufunganya kuwedzera kana kurwisana, kana mamwe maitiro asina kujairika anochinja.
Izvozvo zvakafanana nemigumisiro yevamwe vanhu vanowanzoona mumishonga yekurega-kusvuta, Chantix . Izvi zvinonyanya kukosha kune ani zvake ane nhoroondo yekuora mwoyo kana zvimwe zvinetso zvehutano hwepfungwa. Iyi nyevero inofanira kutorwa zvakanyanya uye chimwe chinhu chaunoda chaizvo kukurukura nachiremba wako.
Dzimwe mimwe migumisiro ye-topiramate inonyanya kuitika mumuviri:
- headache
- kutadza kudzora maziso uye kudedera kwechikamu chemuviri wako
- kuchinja mukukwanisa kuvira zvokudya
- kushaya nguva yekuenda kumwedzi uye kunyanya kunonoka kuenda kumwedzi
- kugona nokushayiwa simba
Zvinokurudzirwawo kuti madhairiro awedzere zvishoma nezvishoma pakutanga, ndokuderera zvishoma nezvishoma usati warega kuitora.
Zvakakosha kudzivisa pakarepo kumira iyi mishonga pasina kubvumirwa kwachiremba.
Dzimwe Mishonga yekudhakwa
Vatsvakurudzi vave vachitsvaka mushonga wokurapa doro. Kune mishonga mitatu chete inogamuchirwa neRDA yekurapa doro muUnited States Aya ndiwo Antabuse (disulfiram), naltrexone, uye Campral (acamprosate).
Antabuse hairevi kuderedza zvido, zvinongoita kuti anwe anzwe achirwara kana achidya doro. Naltrexone naCampral vave vakaratidzirwa kuderedza chishuwo kune vanodhakwa avo vakatosiya kunwa.
Sources
- > Johnson BA, et al. Topiramate yekurapa doro kuvimba: Randedzed Controled Trial. JAMA. 2007; 298 (14): 1641-51.
- > Johnson BA. Pharmacotherapy nokuda kweAllow Use Disorder. Kusvika pari zvino. 2017.
- > Swift RM, Aston ER. Pharmacotherapy Doro Kushandiswa Kwechirwere: Mazuva Ano uye Emerging Therapies. Harvard Review ye Psychiatry. 2015; 23 (2): 122-133.
- > US National Library of Medicine. Topiramate. Medline Plus. 2015.