Nhoroondo yeSNRIs yePanic Disorder
Kazhinji inorayirwa kuti ipe mararamiro emanzwiro uye ekuzvidya mwoyo, serotonin uye norepinephrine reuptake inhibitors ndeimwe yezvinowanzoshandiswa kurapa chirwere chinotyisa .
Chii Serotonin uye Norepinephrine Reuptake Inhibitors?
Serotonin uye norepinephrine reuptake inhibitors, yakaderedzwa kuSNRIs, iboka rimwe remishonga inodzvinyirira. Mimwe yemhando dzakawanda kwazvo dzeSNRIs dzinosanganisira Effexor (venlafaxine), Cymbalta ( duloxetine ), uye Pristiq ( desvenlafaxine ).
Izvo zvinodzvinyirira zvinowanzotarisirwa kuti zvive nehutano hwemagariro, zvakadai sekukuvara kwepfungwa uye bipolar disorder .
SNRIs yakawanikwawo nekuchengeteka uye kubudirira kubata zvirwere zvinokonzera kushungurudzika, kusanganisira panic disorder , kusuruvara-kusagadzikana kwepfungwa ( OCD ), kushungurudzika kwevanhu mune zvepabonde, chirwere chinokonzera kushungurudzika ( GAD ), uye posttraumatic stress disorder ( PTSD ). Uyezve, SSNRIs inogonawo kubata zvakasimba kurwadziwa kunoramba kuripo kunokonzerwa nemamwe mamiriro ezvinhu, akadai se fibromyalgia uye asingagumi kuneta.
Vanoshanda Sei?
Uropi hwemunhu hune mazana emakemikari anokonzerwa nemasikirwo anonzi neurotransmitters. Aya nhume ane basa rokutungamirira ruzivo muhuropi hwose. Zvinotendwa kuti kana imwe kana akawanda emhando idzi idzi dzisina kuenzana, dzinogona kukonzera munhu kukudziridza mafungiro kana chirwere chokuzvidya mwoyo.
Irourotransmitters serotonin uye norepinephrine inofungidzirwa kuti inonyanya kusanganiswa nekuitika kwe panic disorder.
Zvose mapurogiramu eurotransmitter anobatsira pakugadzirisa mamwe mabasa uye manzwiro anokwanisa kuchinja kutanga kwechiitiko ichi. Serotonin inobatanidza nekugadzirisa mafungiro uye kurara. Norepinephrine inobatsira kuti munhu wacho anogadzirisa sei kudzvinyirira uye kuzvidya mwoyo uye inobatanidza nehondo-kana-inopinda mhinduro .
SNRIs inoshanda kuchinja zvose serotonin uye norepinephrine kuburikidza nekudzivirira kero dzomunhu dzomunhu kuti dzirege kukurumidza kunyanya ava neurotransmitter. Nokugadzirisa idzi neurotransmitters, SNRIs inogona kubatsira kuvandudza manzwiro evanhu, kuderedza manzwiro ekuzvidya mwoyo, uye kubatsira kuderedza kutya kwekutya . SNRIs dzimwe nguva yakavhiringidzwa nesarotonin reuptake inhibitors ( SSRIs ) inosarudzwa, iyo inofanana nevanodzvinyirira, asi inoshanda chete kuchinja serotonin.
Pane Mhinduro Dzepamwe Pakushandisa SNRIs?
Zvinokwanisika kuva nemigumisiro yakawanda pakutora SNRIs. Zvimwe zvikamu zvinowanzovhiringidza zveSNRIs zvinosanganisira:
- Nausea kana kurutsa
- Dry mouth
- Kukurova uye kuneta
- Headaches
- Kuita zvepabonde-migumisiro
- Kuwedzera kutya
- Kushungurudza maronda kana kurwadziwa mumimba
- Matambudziko okurara
Izvi zvinokonzerwa nemigumisiro inofanira kupedzisira ichingopera kwenguva. Tsvaga chiremba wako kana migumisiro isingagadziri kana kuipa. Zvinokwanisika kuona chirwere chakakomba chemishonga kubva kuSNRIs. Bata puromiti yako kana chiremba nokukurumidza kana iwe uri kutarisana nezviratidzo zvekurwisana kwezvinodhaka zvinokonzerwa nezvinodhaka, zvakadai sokuputika kwemuromo, chiso, kana rurimi, kusakwanisa kutora kufema kwakanyanya, kunya, kunzwa, kupisa, uye mikoko.
Pane Chekupi Kuchengetedza Kutora SNRIs?
Black Box Warning: Muna 2007, United States Chakudya neDrug Administration (FDA) yakabudisa mazano anonzi black box warning.
Kuburikidza nekunyeverwa, FDA yakanyevera kuti kushandiswa kweSNRIs nemamwe mishonga inoderedza kuzvidzora kunogona kutungamirira kukurudzira kuzviuraya nemabasa. Kunyatsotarisirwa nekuongororwa kunofanira kutorwa kune vana, vachiri kuyaruka, uye vechidiki vari kutora mishonga iyi, sezvavanenge vari pangozi yakakura yekutarisana nemigumisiro iyi yakaipa.
Kubatana Kwemishonga: Mamwe mishonga haafaniri kutorwa pamwe neSNRIs. Chengetedza chiremba wako kusvika-ne-zuva chero ipi zvayo yakatemwa uye kupfuura-in-mishonga yauri kutora.
Doro Kunoshandiswa : Kudha doro kunogona kukwidza kukanganisa kweSNRIs, iyo inogona kukanganisa kubudirira kwemishonga iyi yekurwisa dambudziko.
Special Populations:
Kuberekwa / Kuchechera - SNRIs inogona kudururwa kubva kuna amai kuenda kumwana panguva yekuzvitakura kana mukuyamwisa. Kana iwe uri nepamuviri kana mukoti, kurukurai mikana inogona kutora SNRIs nachiremba wenyu.
Vakwegura Vakwegura - Vanhu vakuru vakwegura vanowanzowanzosangana nemigumisiro yeSNRIs. Kana iwe uri munhu mukuru akakura achitora SNRIs, taura nachiremba wako pamusoro pemigumisiro inogona kuitika.
> Sources:
> Dell'Osso, B., Buoli, M., Baldwin, DS, & Altamura, A. (2010). > Serotonin norepinephrine > reuptake inhibitors (SNRIs) mune zvinetso zvekuzvidya mwoyo: kuongorora kwakakwana kwechirwere chechirwere. Human Psychopharmacology: Clinical uye Ongororo , 25 (1), 17-29.
> Gorman, JM, & Kent, JM (1999). SSRIs uye SNRIs: Kubatana kwakakura kwehutano kupfuura kudarika kukuru. Mukuona Kuongorora Kusagadzikana Kunetseka: Kuongororazve., Jan 1998, Phoenix, AZ, US . Physicians Postgraduate Press.
> Silverman, Harold M. (2010). Pill Book. 14th ed. New York, NY: Bantam Mabhuku.