Zvinokonzera, kubvuma uye kurapwa
Serotonin Syndrome ndiyo inogona kuisa upenyu hunotyisa iyo inokonzerwa nenzvimbo yakakwirira ye serotonin mumamiriro omunhu. Izvi zvinogona kuendeswa mberi nekushandiswa kwe "serotonergic" zvinodhaka, izvo zvinosanganisira marudzi akawanda evanhu vanorwisa zvinodhaka zvakadai seSRRIs (sarudza serotonin reuptake inhibitors) saPaulil neCelexa , tricyclics seamitriptyline uye trimipramine, uye MAOIs (monoamine oxidase inhibitors) saNardil uye Parnate.
Zvimwe zvinhu zvinogona kuunza sarotonin syndrome zvinosanganisira St. John's wort , cocaine, L-tryptophan, lithium, amphetamines, ecstasy, uye LSD.
Mukuwedzera, mamwe mapepa asina mishonga anogona kuchinja huwandu hwe serotonin muropa. Nokuda kwechikonzero ichi, zvakakosha kuti vese vanachiremba vako vanorayira mishonga nguva dzose vanoziva mishonga nemishonga inowanikwa ikozvino.
Zvose izvi zvinodhaka uye zvinhu zvinokonzera neurotransmitter serotonin neimwe nzira. Vamwe vanovhara nerve receptors; vamwe block reuptake ; vamwe vanonoka kuparara kwe serotonin; vamwe vanowedzera kusunungurwa kwe serotonin (nokuda kwemuenzaniso, ona Mishonga yemigwagwa uye BP: Ecstasy ). Mimwe miviri yevanhu inononoka kudarika zvinowanzoitika pakugadzirisa serotonin. Nolan uye Scoggin vakaudza kuti varwere vane zvirwere zvevascular vari pangozi yakawanda ye serotonin syndrome. (Ona Vatumwa veBongo nokuda kwetsanangudzo iri nyore kunzwisisa nzira iyo mamwe emabasa aya anoshanda.)
Zvinenge zvose zvinodhaka zvinokonzera kuti varwere vanofanira kumirira kwemavhiki masere (dzimwe nguva zvimwe) pakati pekuchinja pakati pe-MAOI-mhando yemishonga uye imwe mhando ye antidepressant (mune imwe nzira). Chimwe chezvikonzero chikuru zveizvi ingozi yokuti kuva nemhando dzose dzemishonga mune imwe nzira inogona kutungamirira serotonin syndrome.
Prozac (fluoxetine) kunyanya inotora vhiki dzinoverengeka kuti ibudiswe kunze kwemuviri.
Zviratidzo
Zviratidzo zvinowanzoitika zve serotonin syndrome zvinosanganisira:
- Kamwe kamwe-kamwe kana kutyisa-kufanana-kufanana
- Kupera kana kuvepa
- Slow or fast pulse
- Fever
- Headache
- Kufunganya
- Tsvina yakasimba
- Kusanganiswa
- Kusagadzikana
- Anokurudzira kutuka
- Kupopota
- Poor coordination
- Kukurumidza kufema
- Kusagadzikana kwepfungwa
- High blood pressure
- Kudzora
Pane imwe chirwere chinokonzerwa nemishonga, neuroleptic malignant syndrome (NMS), iyo ine zvimwe zviratidzo zvakafanana serotonin syndrome. Apo vanachiremba vari kuongororwa nemurwere ari kuratidza zviratidzo izvi, zvinokosha kuti vazive zvakanyanya sezvinobvira pamusoro pemashoko ekurapa kwemurwere. Izvi ndizvo zvinoreva kuti serotonin syndrome inowanzomhanya nokukurumidza mushure mokutanga mishonga inotanga, apo NMS inowanzoita anenge mwedzi kuratidza.
Kurapa
Mutsara wokutanga wemishonga ndeyekuregerera madhiragi ose anokonzera serotonin. Benzodiazepines inogona kubatsira kubatsira kuderedza zviratidzo zvemisumbu, uye kutsigira kurapa kunogona kudiwa pamamiriro ezvinhu akadai sekufema kunetseka. Zvinodhaka zvinonyatsoshanda maererano ne serotonin zvinogona kubatsirawo.
Muzviitiko zvakawanda, zviratidzo zvinokurumidza kukurumidza kana izvi zvaitwa uye murwere anowanazve zvakakwana.
Zvisinei, inofanira kusimbiswa kuti serotonin syndrome inogona kuuraya, saka zvakakosha kutsvaka rubatsiro pakarepo kana iwe kana munhu waunoda akawana chero humwe hwezviratidzo zvataurwa apa mushure mekunge watanga mishonga inodzvinyirira kana kuchinja kubva kune imwe kuenda kune imwe.
SSRI Discontinuation Syndrome
Izvo zvinofanira kuonekwa kuti zvimwe zviratidzo zvakafanana zvinoratidzwa pamusoro apa zvinogonawo kuitika kana munhu akangoerekana arega kutora chirwere chinopesana nemhepo kana kuti akachikurumidza kubva. Kushungurudzika, kuora musoro, kutyisa-kufungidzira, kusawirirana kwakashata, chills uye kusakanganiswa kwemajeri zvimwe zvezvinhu zvinowanzoenderana neyese syndromes.
Ona SSRI Discontinuation Syndrome yekutarira zvakadzama pane izvozvo.
> References:
> Nolan, S., uye Scoggin, JA "Serotonin Syndrome: Kuziva uye Kutungamirirwa." US Pharmacist 23: 2. http://www.uspharmacist.com/oldformat.asp?url=newlook/files/feat/acf2fa6.htm.
> Gomersall, C. "Serotonin Syndrome." July 2006
> HealthyPlace.com. "Monoamine > Oxydase > Inhibitors (MAOIs)."