Chii Chinosiyana pakati peSSSNRIs uye SNRIs uye NRIs?
Kune humwe hunyongeri pamusoro pemashoko aya SSNRI uye SNRI. Ndeupi musiyano pakati pekusarudza serotonin-norepinephrine reuptake inhibitors (SSNRIs) uye kusarudza norepinephrine inhibitors (SNRIs), uye aya anogona kushandiswa zvakasiyana here?
SSNRIs vs SNRIs - The Confusion in Terms
SNRI inomirira zvose sarotonin-norepinephrine reuptake inhibitor uye serotonin-norepinephrine reuptake inhibitor.
SSNRI inomirira chete serotonin-norepinephrine reuptake inhibitor asi inoshandiswa zvakasiyana-siyana neSNRI iye zvino uye kazhinji isingashandisi yoga. Zvadaro panewo sarudzo norepinephrine reuptake inhibitors, inowanzonzi NRIs.
Kune Zvakarewo SSRIs
Asi rumwe rutivi rwemishonga, SSRIs kana kusarudza serotonin reuptake inhibitors , inogona kuita izvi kunyanya kuvhiringidza. SSRIs inosanganisira mishonga yakadai seProzac, Paxil, Zoloft, uye Celexa. Sezvo neSNNRIs kana SNRIs, vanogona kukonzera mania kuvanhu vane bipolar disorder uye havasati vashandiswa chete.
Basa re SSNRIs uye SNRIs
SSNRIs kana SNRIs inoshanda nekudzivisa reuptake yevanaurotransmitter , makemikari anotumira mashoko kuburikidza neuropi. Reuptake inhibitors inoshanda nekudzivisa reuptake yemakemikari nemasero kubva kwavakange vakavanzwa, zvichiwedzera kuwanda kwemakemikari aripo mumusasa (uye anokwanisa kusunga nesero rinotevera rekushandisa kutumira shoko.) Nemamwe mazwi, reuptake inhibitor yaizoshanda nenzira yakafanana nekudzikisa basa remarara rinotumirwa kunotora tsvina.
Muchiitiko ichi, zvisinei, "dongo" inomukemikari inoita basa rinokosha pakugadzirisa nekugadzirisa mafungiro.
SSNRIs (kana SNRIs) inodzivisa mapurogiramu serotonin (dzimwe nguva anotumidzwa se "kunzwa zvakanaka" chemikemikari) uye norepinephrine, zvichiita kuti kuvandudza mafungiro.
Zvinodhaka munharaunda iyi zvinosanganisira:
- Cymbalta (duloxetine) inoshandiswa kuporesa kuora mwoyo, chirwere chinokonzera kushungurudzika (GAD) uye mamwe marwadzo.
- Effexor (venlafaxine) inoshandiswa kurapa kuora mwoyo, GAD, panic disorder uye kushungurudzika kwevanhu munzanga .
- Savella (milnacipran) ndiyo sarotonin-norepinephrine reuptake inhibitor inobvumirwa kugadzirisa fibromyalgia.
- Pristiq (desvenlafaxine) inogamuchirwa kupedza kuora mwoyo .
- Fetzima (levomilnacipran) inogamuchirwa kuti iite kuderedza.
Migumisiro Yechiratidzo yeSNRIs
Mishuwo yakajairika inowanzosiyana pakati pevanhu vakasiyana asi inogona kusanganisira:
- Chizutu
- Sweating
- Dry mouth
- Kushungurudza mudumbu
- Kuneta
- Headache
- Constipation
- Zvepabonde nenyaya
- Kufunganya
- Dambudziko rokurara
- Appetite kurasikirwa
Sarudza Norepinephrine Reuptake Inhibitors (NRIs)
NRIs imishonga inobvisa reuptake ye norepinephrine asi haingawedzeri reuptake ye serotonin muuropi. Zvinoshandiswa zvirwere zvakadai sekunetseka kwepfungwa / hyperactivity disorder (ADHD), kuora mwoyo uye kuzvidya mwoyo. Mishonga yakajairika inosanganisira:
- Strattera (atomoxetine) inonyanya kushandiswa kurapa ADHD.
- Ludiomil (maprotiline) inoshandiswa kuora mwoyo uye kuzvidya mwoyo.
Migumisiro Yechiratidzo yeNRIs
Zvimwe zvinokonzerwa nemigumisiro yeNRIs inosanganisira:
- Ganda redness
- Hives
- Itching
- Mapundu
- Iva nemwoyo murefu zvisina kufanira
- Zvepabonde nenyaya
- Kuneta kana kushaya simba
- Chiratidzo chakasvibiswa
- Constipation
- Chivara chine chiedza
- Kushungurudza mudumbu
SNRIs muBipolar Disorder
SNRI inogona kushandiswa kune vanhu vane bipolar disorder, asi inofunga kuti kushandiswa kwavo kunofanira kunge kwakagadzirirwa kushandiswa kwenguva pfupi kwepfungwa huru yepipolar depression. Zvimwe zvidzidzo zvakawana zvinodhaka zvakadai seSNRI dzinobatsira mune izvi, asi huwandu, kushandiswa kwevanhu vanodzvinyirirwa nehupfungwa hwekuita bipolar hakuratidzi kuti kune zvakakosha pamiganhu yepachirwere chechirwere. Izvi ndezvechokwadi kunyange kana zvichishandiswa nemafungiro emagadzirirwo kana maawa anypical antipsychotic. Kusiyana neizvi, kushandiswa kwenguva refu kweSNRIs (kana SSRIs) kunowedzera hutachiwana hwehutachiona hunopesana-induced mania kana hypomania .
Kushungurudzika-Kunokonzera Mania NeBipolar Disorder
Sezvakataurwa, zvinodzvinyirira zvakadai seSNRIs zvinogona kukonzera chiitiko chevanhu mumunhu ane bipolar disorder. Kana iwe une bipolar I disorder , iwe ungangodaro unoda kugadzirisa mafungiro kana antipsychotic zvakare kana chiremba wako anokurudzira mishonga inodzvinyirira.
Mimwe Mishonga Inoshandiswa Bipolar Disorder
Kune dzimwe mimwe mikana yemishonga inowanzoshandiswa kurapa bipolar disorder. Izvi zvinosanganisira:
Maitiro Anodzivirira
Kungofanana nezita racho rinotsanangura, mafungiro ekugadzirisa mafungiro anobatsira kuchengeta mafungiro ako akasimba uye anobatsira kudzivirira kuva ne manic kana hypomanic episodes. Mimwe mishonga inoshandiswa sezvinosimudzira mafungiro echokwadi anticonvulsants anoshandiswa kune vanhu vane chirwere chekufa. Zvimwe zvinowanzogadzirisa mafungiro ndezvekuti:
- Lithium
- Depakote (divalproex sodium)
- Tegretol (carbamazepine)
- Lamictal (lamotrigine)
Zvinokonzerwa nemigumisiro yemamiriro ekusimudzira mafungiro ari kunzwa nyota, kukurumidza, kushungurudzika mumimba, kugumburwa, kuputika kwekutaura, kuzvimba, kudengenyeka, kuratidzwa kwemaonero, kusagadzikana kwepfungwa, kuva nekukanganwa kazhinji, kukanganisa uye kusviba.
Anti-Psychotics
Chirwere chinopesana nemasikirwo (zvichida chinonzi antipsychotic kana antiyyptic antipsychotic ) chinogona kuwedzerwa kana kushandiswa muhurongwa hwako hwekurapa kana iwe uchinetseka nemanzwiro ako kunge akaderera kana kuti akakwirira. Mienzaniso yevanopesana nenyuchi dzinosanganisira:
- Risperdal (risperidone)
- Geodon (ziprasidone)
- Zyprexa (olanzapine)
- Abilify (aripiprazole)
- Latuda (lurasidone)
Zvimwe zvinokonzerwa ne antipsychotics zvinogona kusanganisira kuderera kweropa, kusvinura, kuvhara, kuwana uremu, kugumburwa, kugona, muromo wakaoma, kurutsa, tic kana kutengesa. akachena masero ekuyera ropa uye kushungurudza mudumbu.
Kurwisa Kuzvidya Mishonga
Kana iwe uine dambudziko nekuzvidya mwoyo uye / kana kurara kwako, nyanzvi yako yehutano hwepfungwa inogona kukupa iwe mishonga inopesana nezvinodhaka inonzi benzodiazepine kuti ibatsire. Zvinowanzobatanidza:
- Xanax (alprazolam)
- Klonopin (clonazepam)
- Valium (diazepam)
- Ativan (lorazepam)
Zvimwe zvinokonzerwa nemishonga inopesana nezvinokanganisa zvinogona kusanganisira kuvhiringidzika, kukotsira, kushaya simba, kuoma kwekufema, kutaura kwekutaura uye zvinetso zvekubatanidza. Vanowanzobatwa vasati vavata kuti vakubatsire kurara, zvakadaro, kuitira kuti iwe usakwanisa kuona izvi.
Shoko Rinobva
Kunyange zvazvo SNRIs inogona kubatsira kuvanhu vane kuora mwoyo, basa ravo pakurapa kuora mwoyo kunoenda nehupipolar disorder hakusi nyore. Ne bipolar disorder, idzi mishonga inofanira kushandiswa chete pamwe chete nemafungiro emagariro kana antipsychotic mishonga, uye inongova nguva pfupi kwenguva pfupi yepamusoro yepipolar depression apo inofungidzirwa kuti zvikomborero zvichapfuura njodzi.
Zvidzidzo zvinoratidza kuti kushandiswa kwemazuva mazhinji, pamwe nekukwanisa kwekugadzirisa mania kana hypomania, kunogona kuguma nemigumisiro yevarombo yevanhu vane bipolar disorder. Zvechokwadi, munhu wose ane bipolar disorder akasiyana, uye mupfungwa yako wepfungwa anogona kunzwa kuti kushandisa kwenguva refu kwemishonga iyi kuchakubatsira iwe pachako.
Sources:
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