GABRG3 Inobatana Yakabatana neAdha Inodedera
Masayendisiti achiongorora DNA kubva kune vanhu vanopfuura 10 000 vanoita zvirongwa zvekudhakwa uye mhuri dzavo dzakaona geni rinoita seirikubatanidzwa nehuwandu hwekudhakwa kwechidhakwa.
Ijini inobatana newaini inobvumira kufamba kweGamma-amino butyric acid (GABA) pakati pemasero emagetsi. GABA ndiyo inonyanya kushandiswa kwemakemikari mumutambo wepamusoro wemagetsi.
Ichi chidzidzo ndicho chekutanga chekuwana hukama pakati peiyo geni uye kudhakwa kwewaini , vatsvakurudzi vakati.
Genesisi uye Migumisiro Doro
"Paiva nemiganhu yeuchapupu kubva kune zvimwe zvidzidzo - zvidzidzo zvemhuka, in vitro zvidzidzo - izvo zvakaratidza kuti GABA receptors inobatanidzwa mune zvinoita zvekuita doro," anodaro munyori anotungamirira Danielle M. Dick, Ph.D., purofesa anotsigira kutsvakurudza masayendisiti kuWashington University School of Medicine muSt. Louis. "Nemhaka yokuti gABA receptor geni yaive yakakodzwa uye zvidzidzo zvekare zvaibatanidza nzvimbo iyi pamusoro pechromosome 15 kusvika kunodhakwa , takapinda muzvikamu zvitatu zveGABA receptor asi takawana kushamwaridzana kwakakura nomumwe wavo."
Sangano Rokubatanidza Rudzi Rwenyika kuGenetics of Alcoholism (COGA) chirongwa chinosanganisira kubvunzurudzwa uye DNA samples kubva kune vanhu vanopfuura 10 000 vanorwara uye vasingachaperi doro rekurapa uye mhuri dzavo.
Mhuri mumubatanidzwa weCOGA inowanzove nenhengo dzakawanda dzine doro.
Doro Gene Kuzivikanwa
Ichi chidzidzo chikamu chejekiti yeCOGA. Vatsvakurudzi vakaongorora DNA kubva kumhuri 262, vanhu vanosvika 2 282. Vakatarisa majena matatu pamusoro pekromosome 15 - GABRA5, GABRB3 uye GABRG3 - vanogara pedyo zvikuru pamwe chete nekromosome.
Kushandisa zviratidzo zvinonzi SNPs (single single nucleotide polymorphisms), vakaongorora kusiyana kwemajeri ezvibatanidza.
Maitiro Aunoita Nengozi Hazvizivikanwi
Zviratidzo zvakaratidza zviduku zvakasiyana-siyana zvemajini zvakaratidzika kuti zvinokonzera njodzi yekudhakwa nedoro , asi mune imwe yemagenhi: GABRG3.
"Hazvizivikanwi kuti GABRG3 inokonzera sei dambudziko rekudhakwa," vakatsvakurudza vakati. "Ongororo yekare yakaratidza makemikari anowedzera GABA receptor basa anogona kukurudzira maitiro ekudhakwa, zvakadai sedation, kurasikirwa nekuzvidya mwoyo uye zvinetso nemagetsi ekubatanidza. Kusiyana naizvozvo, makemikari anoderedza GABA receptor basa anogona kuita zvakasiyana.
Nzira Yokunwa Doro?
"Izvi zvinoratidza kuti nenzira imwe neimwe gABA yekugamuchira inogona kuve yakabatanidzwa mune izvi zvinokonzerwa nemitemo," anodaro Dick. "Asi isu hatizivi kuti sei, saka hatigoni kutaura kuti nzira inogona kuve iri inotungamirira kubva kuGABA gadziriro yemagetsi kusvika kune doro."
"Kuwana kuti GABA inobatanidzwa mukudhakwa nekudhakwa kunotsigira nheyo yemazuva ano iyo yakagadziriswa kudhakwa kwechidhakwa inogona kupiwa nhaka sechikamu chehutano hwehuropiti," akadaro Dick. "Vanhu vari panjodzi yekudhakwa zvinodhaka vanogona kugara nhaka yejena dzakasiyana-siyana dzinobatsira muhurumende iyi.
Zvichida doro rinowanzoita kuti munhu afare, zvichiita kuti vanhu vane chirwere chinotyisa chinoshandiswa kushandisa doro kakawanda kuitira kuti vadzidzise hutano hwepfungwa. Izvozvo, zvaizovaisa pangozi yakakura yekuwedzera kunwa doro. "
Kwete Kutongerwa Kuva Doro
Iye akati zvakakosha kuratidza kuti maitiro ekugadzirwa kwemazwi haasi kureva kuti munhu anenge atongerwa kuva doro.
"Chimwe chikonzero chakaoma zvikuru kuwana mazamu anobatanidzwa mune zvinetso zvepfungwa ndezvekuti pane kuwirirana pakati pei genetic uye zvakatipoteredza," anodaro. "Munhu anogona kutakura marudzi ose ejeni anowanzoita kuti awedzere kunwa doro, asi kana vasingatombotomwi, havazove doro."
Kunobva:
Dick, DM, et al. "Kushamwaridzana kweGABRG3 Nedoro Dzokuvimba." Kunwa doro: Chipatara & Ongororo Yokuongorora January 2004