Kirasi yekutanga yemishonga ichiri kushandiswa kurapa kushushikana kwepasypical
Monoamine oxidase inhibitors (MAOIs) ndiyo yaiva yekutanga yekudzivirira mwoyo yakagadzirwa kutanga kwema1950. Kunyange zvazvo zvakanyanya kuwedzererwa nedzimwe makirasi emishonga, MAOIs inenge iine nzvimbo yayo mukurapa, kunyanya kune vanhu vakaonekwa vane atypical depression .
Maitiro MaOI Anoshanda sei
Maitiro anonyanya kurongerwa nemakemikari muuropi anonzi neurotransmitters .
Kune mhando mitatu yemaurotransmitter inowanzobatanidzwa mumafungiro- serotonin , norepinephrine , uye dopamine -yose iyo inotsanangurwa se monoamines (zvinoreva kuti ine imwe yemamino acid boka).
Inoshandiswa neurotransmitter inowanzoparadzwa neine enzyme inonzi monoamine oxidase. Zvisinei, kana chirongwa ichocho chisina simba uye chakawanda kwazvo chinonzi neurotransmitter chakaparadzwa, munhu anogona kukura neuropsychiatric zviratidzo nenzira yekuora mwoyo.
MAOIs basa nekuvhara basa re enzyme iyi, zvichiita kuti zvikwata zvepamusoro zvevanokonzerwa neurotransmitter uye kuvandudzwa kwezviratidzo zvekuora mwoyo.
MAOI zvinodzvinyirira zvinotenderwa kushandiswa muUnited States zvinosanganisira:
- Marplan (isocarboxazid)
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- Emsam - selegiline transdermal
Kunyange zvazvo MAOI isingawanzoshandiswa mumutsara wokutanga kurapwa kwekuora mwoyo, iyo inonyanya kushanda mumamiriro ezvinhu ekunyadzisira kunotyisa . Iyi ndiyo nzira yekuora mwoyo inoratidzirwa nekunyanya kudya, kunyanya kuora, kunzwisirwa kukanganisa, uye kutungamirira kuora mitezo (kunonoka kutama nekuda kwekuona kunetseka mumakumbo nemaoko).
MAOI anowanzoshandiswa kurapa chirwere cheParkinson uye anogona kushandiswa seimwe nzira prophylactic (inodzivirira) kurapwa kwemagraines akaoma.
Chikonzero nei MAOI Maitiro Mashoma Anowanzoshandiswa
Mazuva ano, kuora mwoyo kunowanzobatwa kune rimwe boka rechirwere chinonzi serlicon serotonin reuptake inhibitors (SSRIs) iyo inosanganisira Zoloft (sertraline) uye Paxil (paroxetine) .
Izvi zvinokonzerwa, muchikamu, kuwanda kwemigumisiro uye kusangana kwemishonga kunoonekwa nevanhu vari MAOIs.
Chimwe chezvinonyanya kukosha ndezvokudya zvinodyiwa izvo vanhu vari MAOI vanoda kuchengetedza kudya uye zvinwiwa zvine tyramine . Izvi zvinosanganisira chiropa uye zvakabikwa zvokudya zvakadai sekizi uye doro. Nokuti tyramine inokanganisa kuwedzera kweropa uye MAOI inowedzera tyramine, chero kuwedzera kune kudya kunogona kutungamirira kune dambudziko guru rehutano uye zvichida kufa.
MAOI anobatanidzwawo nezviratidzo zvekuregererwa kana kurapwa kwambomira. Kunyange zvazvo vamwe vanodzvinyirira vanewo rutivi rwunopinza, inofungidzirwa kunyanya kuve neMaOIs. Somugumisiro, mishonga inoda kudiwa kubva pasi pekutariswa kwechiremba uye inopedzerwa nepfungwa yekurapa chero ipi zvayo kubva kwemavhiki maviri kusvika mashanu kusati kwavapo mushonga mutsva unodzvinyirira unotanga.
Kubatana Kwemishonga
Chimwe chinetso chikuru cheMaoIs ndechekuwandisa kwakasiyana-siyana kwekushandisa kwezvinodhaka munhu anogona kuonekwa panguva yekurapa. Izvi zvinosanganisira mishonga yepamutemo uye kupfuura-the-counter nemishonga yemigwagwa. Kunze kwekutarisirwa zvakanaka, maMaOI anogona kupindira mune dzimwe mishonga kana kunyange kuderedza kushanda kweMaOI pacharo.
Nhamba yekubatana kwemishonga inosanganisira:
- Amphetamines
- Antihistamines
- Antipsychotics
- Mishonga yeAshmma
- Ropa kudzvinyirira mishonga
- BuSpar (buspirone)
- Cocaine
- Demerol (pethidine)
- Prozac (fluoxetine)
- Ritalin (methylphenidate)
- Tegretol (carbamazepine)
- Tricyclic vanodzvinyirira
- Tryptophan
- Wellbutrin (bupropion)
Iko, chaizvoizvo, inotaridzika ine ngozi kana MAOI inotorwa ne cocaine, Demerol, Prozac, kana chero tricyclic inodzvinyirira. Kazhinji kutaura, MAOIs haifaniri kushandiswa nemhando ipi neipi yehutachiona hwehutachiona, kusanganisira imwe MAOI.
Shoko Rinobva
MAOI, kunyange zvisingawanzoshandiswa mazuva ano kupfuura SSRIs, inogona kushanda mune zvakajeka, zvakaoma-kubata-maitiro.
Kana zvakatemwa MAOI, zvakakosha kuti iwe upiwe chiremba wako pamusoro peipi uye nemishonga yose yaunotora, yemutemo kana zvimwe. Uyezve, kana chirwere chakatangwa, haufaniri kutora chero mishonga, kusanganisira pane-in-inotonhora uye mishonga yemishonga, pasina kutanga kutaura nachiremba wako.
> Kwakabva:
> Grady, M. na Stahl, S. "Practical guide yekuraira MAOIs: debunking myths uye kubvisa zvipingamupinyi." CNS Spectrums 2012; 17: 2-10. DOI: 10.1017 / S109285291200003X.