Zvose Nezve Trycyclic Antidipressants for Bipolar Disorder and Depression
Chiremba wako angangodaro akarayira tricyclic mishonga inodzvinyirira kuporesa kuora mwoyo kwako, bipolar disorder, kana kune imwe mamiriro akadai sekurwadziwa. Mishonga iyi inoshanda sei? Ndezvipi zvinodhaka zvinotorwa kuti tricyclic zvinodzvinyirira, uye ndezvipi zvimwe zvinowanzova nemigumisiro yaunofanira kuziva?
Chii chinonzi Tricyclic Antidepressants?
Tricyclic vanodzvinyirirwa vave varipo kwenguva yakareba, pamwe chete nemishonga inotanga iri mukirasi remakemikari eve yakagadzirwa muma1950.
Kunyange zvazvo mishonga mitsva (kazhinji ine mikana yakawandisa uye pangozi yakaderera yekuwedzeresa) ikozvino yavapo, tricyclic vanodzvinyirira vanoramba vachiine nzvimbo mukurapa bipolar chirwere, kuora mwoyo, pamwe chete nezvimwe zvinhu zvakadai sekurwadziwa kusingaperi.
Chekutanga chetricyclic vanodzvinyirira, Tofranil (imipramine) yaive kuwanikwa kwakakosha uye chaizvoizvo akabatsira vashandi vepfungwa kuti vagadzirise maonero avo pamusoro pekuti kuora mwoyo kunowanikwa sei. Tricyclic vanodzvinyirira vanonzi maitiro emakemikari akawanda emishonga iri mukirasi-mishonga inoumbwa nezvindori zvitatu zveatomu.
Tricyclic Anodzvinyirira Anoshanda Sei?
Sezvo kuwanikwa kwe tricyclic vanodzvinyirira, tave tichidzidza zvakawanda pamusoro pekuti kusagadzikana kwemakemikari muuropi kunobata sei zvirwere zvakawanda zvekuora mwoyo. Izvi hazvishamisi kune avo vakararama nekuora mwoyo, sezvavakaona kuti zvirwere zvekuora mwoyo zvinogona kuitika kunyange kana zvinhu zvose muupenyu zvichiita sezviri kufamba zvakanaka.
Kuva neshamwari nemhuri kunzwisiswa kwehupenyu hwehupenyu hwekuora mwoyo uye dzimwe zvirwere zvepfungwa zvinobatsira, kuti vasaita mazwi anorwadza akadai sokuti "kungoerekana uchibuda." Mhinduro dzakadai saizvi hazvina kusiyana nekuudza mumwe munhu ane chirwere cheshuga uye chirwere cheshuga chepamusoro chekutsvaga.
Kukurukurirana pakati pemasero emasero akasiyana-siyana ari muuropi kunoitika nemakemikari anozivikanwa seveurotransmitters . Aya makemikari anosunungurwa kubva kumagumo eine nerve cell, munzvimbo inenge iri pakati pemasero (synapse), uye anotorwa kusvika mune imwe nerve sejeri seyo nzira yekuendesa mashoko.
Tricyclic zvinodzvinyirira zvinoshanda nekuwedzera huwandu hwevana neurotransmitters serotonin uye norepinephrine (nekudzivirira muviri wako kuti usaputsa aya makemikari.) Sezvo vachiwedzera huwandu hwevaya vaviri vezvematongerwo enyika, vanoonekwa se "zviito zviviri" zvinorwisa vanodzvinyirira.
Pamusoro pemigumisiro pane serotonin uye norepinephrine, tricyclic inodzvinyirira inoshandawo nekuvhara chiito cheumwe muurotransmitter, acetylcholine .
Kusiyana ne tricyclic vanodzvinyirira, mamwe evanhu vatsva vanodzvinyirira vanoshanda zvikuru nezviito zvavo pane serotonin. Semuenzaniso, sarotonin reuptake inhibitors (SSRI) inosarudza seprozac (fluoxetine) inowedzera huwandu hwe serotonin muuropi asi kwete norepinephrine. (Izvozvo zviito zvevarwere vanopesana nemanzwiro zvakanyanya kudarika izvi, naizvozvo muenzaniso uyu unoshandiswa sekuenzanisa nyore.)
Pasi pose, zvinonzwa kuti mazinga epamusoro e serotonin uye norepinephrine muuropi anoita kuti pave nemafungiro akanaka.
(Dzidza zvakawanda pamusoro pemakemikari ekuora mwoyo .)
Ndezvipi Zvirongwa Tricyclic Antidepressants Inoshandiswa?
Tricyclic zvinodzvinyirira zvinogona kurongerwa kana "pane mazita" kana "kunze kwereti." Pamusoro pemashandisirwo anoshandiswa anosanganisira izvo izvo mishonga iri ikozvino FDA-inogamuchirwa. "Kunyoresa" kushandiswa kwemishonga yakawanda kwakakurumbira, uye kunoreva kushandiswa kwemishonga yakagamuchirwa neDFA, asi nokuda kwechiratidzo chakasiyana pane icho chakabvumirwa.
Pamusoro pemashandisi ekushandisa tricyclic zvinodzvinyirira zvinosanganisira:
- Kuora mwoyo
- Obsessive compulsive disorder
Kunyoresa tsamba inoshandiswa kwe tricyclic zvinodzvinyirira zvinosanganisira:
- Utano husingaperi hwakadai saElavil nokuda kwekutambudzika kusingaperi
- Phantom muthu unorwadza
- Bedwetting (enuresis)
- Migraine musoro musoro kudzivirira
- Bulimia
- Panic disorder
- Bipolar disorder
- Chronic pruritis (itching)
- Chronic hiccups
- Kurara kunokonzera (doxepin iFDA inogamuchirwa kuti irege kugona)
- Irritable bowel syndrome
Vanachiremba vanosiyana nenzira yakanyatsonaka ivo vari kurondedzera mishonga yakadai seyi "off label" asi, kunyanya panyaya yekurwadziwa kusingaperi uye kubata, pane zvidzidzo zvakawanda zvakatsigira kushandiswa uku.
Inotora Nguva Yakadini Kutora Mishonga Iyi Kushanda?
Tricyclic vanodzvinyirira, sevamwe vanodzvinyirira, vanowanzoita vhiki dzinoverengeka (kazhinji masvondo matanhatu kusvikira masere) vasati vashanda kuderedza kuderedzwa. Nokuda kwechikonzero ichi, vanachiremba vanowanzokurudzira kupfuurira mushonga kwemwedzi miviri kusvika mitatu usati wachinja kune rumwe rudzi rwemishonga. Ichi chikonzero chinofungidzirwa kuti ndeyekuti mishonga iyi yose inotora nguva yekudzorera kemikari yakakosha muuropi. Izvi hazvirevi kuti hapana chaunogona kuita iwe uchimirira. Vanhu vazhinji vanowana dzimwe kurapa dzakadai sepfungwa inobatsira zvikuru pakurapwa kwemamiriro ezvinhu akadai sekuora mwoyo uye bipolar disorder, uye izvi zvinogona kutanga kutora zviratidzo zvekuora mwoyo musati mvumo "inopindira."
Mishonga Inonzi Tricyclic Antidepressants
Mimwe yemishonga inorondedzerwa se tricyclic inodzvinyirira inosanganisira:
- Elavil (amitryptyline)
- Ascendin (amoxapine)
- Anafranil (clomipramine)
- Pamelor (nortryptyline)
- Norpramin (deipramine)
- Tofranil (imipramine)
- Vivactil (protryptyline)
- Surmontil (trimipramine)
- Sinequan (doxepin)
Maitiro Anowirirana Maitiro eTricyclic Anodzvinyirira
Kunyange zvazvo imwe yevricyclic inodzvinyirira yakasiyana zvakanyanya nevamwe, inowanzova nemigumisiro yakafanana. Migumisiro yakajairika inosanganisira:
- Dry mouth
- Constipation
- Kutsemuka (mamwe mishonga inogona kugadzirirwa kurara)
- Chizutu
- Kuwedzera kudya kudya
- Kuwedzera kwehupfumi (inogona kuva yakakosha)
- Blurry chiratidzo
- Kuchinja mune zvepabonde
Kana wakamboita zvakaipa kune Tegretol (carbamazepine), kana chero mishonga yapfuura yepfungwa, ita kuti uudze izvi kune chiremba wako kana achikupa iwe kutora tricyclic antidepressant.
Mukuwedzera, kune mhinduro dzevana vane matambudziko apo vanaamai vavo vakatora tricyclic vanodzvinyirira pakupera kwekuzvimba. Tricyclics inopinda mumukaka wemvere. Kana iwe uri nepamuviri, uchiyamwisa kana kuronga kuti uve nepamuviri, kurukura nezvakabatsire nezvengozi dze tricyclic vanodzvinyirira nechiremba wenyu.
Kubatana Kwezvinodhaka neTricyclic Antidepressants
Mimwe yemigumisiro ye tricyclic inodzvinyirira inogona kuwedzerwa nemimwe mishonga. Chiremba wako anofanira kuziva kuti ndezvipi zvimwe zvinodhaka zvauri kutora, kusanganisira mishonga yemishonga, pamusoro pemiti-zvinodhaka, nemishonga yemugwagwa. Semuyenzaniso:
- Tricyclics inogona kukonzera mwoyo arrhythmias -kukurumidza, kukura kana kusagadzikana kwepfungwa. Zvinodhaka zvinogona kuita izvi zvakanyanya kunosanganisira amphetamines, mapiritsi anodya, decongestants, mishonga yemishonga, uye mishonga yekurapa.
- Kurara mapiritsi, mishonga yekurapa, antihistamines, mishonga inononoka, antihistamines, runyararo uye doro rinogona kuwedzera nzvimbo dzekutengesa tricyclics.
Zvimwe zvinodhaka zvinogona kukonzera matambudziko kana zvichitorwa ne tricyclic zvinodzvinyirira zvinosanganisira, asi hazvirevi kune:
- Psychiatric medication
- Ropa-thinning drugs
- Mishonga yetachiona yakanyanyisa
- Tagamet (cimetidine)
- Rimwe ropa rinodzvinyirira mishonga
Pakupedzisira, zvakakomba, kunyange zvinetso zvinouraya zvinogona kuitika kana kubatanidza tricyclic vanodzvinyirira nehumwe hutano hwezvinodhaka hunozivikanwa seMaO inhibitors , kana kuti kubva pane imwe kuenda kune imwe. Kutora iyi miviri miviri yemishonga pamwe chete kana mukati memavhiki maviri kune mumwe nemumwe kunogona kukonzera kutonhora kwemuviri kusinganzwisisiki, kunyanya kukanda ropa, kusuruvara kukuru, nekufa. Chiremba wako anogona kuvarayira pamwe chete, asi mamiriro aya anofanira kunge ari pasi pekutarisa kwechiremba pedyo.
Pasi Payo Pamusoro peAkadzvinyirira
Kunyange zvazvo kune mishonga yakawanda inopesana nehutachiona iyo inoshanda kuvanhu vakawanda, kazhinji ine zvisingabatsiri, madhiragi aya achiri kuita basa mukurapa kuora mwoyo. Sezvo vakadaro, dzimwe nguva vanokwanisa kudzora zviratidzo zvekuora mwoyo izvo zvisina kudzorwa pamishonga mitsva. Mukuwedzera, vanoita kunge vane basa mukurapa kwemamiriro ezvinhu akadai sekurwadziwa kusingaperi.
Izvozvo zvakati, tricyclic vanodzvinyirira inofanira kushandiswa nekuchenjerera kune vakwegura nekuda kwerutivi rwemaitiro avo, kunyanya kuderedza zvinhu uye anticholinergic nemigumisiro yakadai sechezzinesi, maonero asina kunaka, uye kuvimbiswa.
Hazvina mhosva kuti mishonga ipi yaunorayirwa, zvakakosha kuti iwe uve nhengo inoshingaira mukutarisira kwako uye utsire kune zvido zvako zvekurapa. Taura nachiremba wako kana zviratidzo zvako zvisina kudzorwa nemishonga yako, uye taura nezvemamwe matambudziko aunoona. Munhu wese akasiyana, uye nzira chete iyo chiremba wako anoziva kuti uri kunzwa sei nemishonga yako kana iwe uchigovera pfungwa dzako. Mamiriro ezvinhu akadai bipolar disorder uye kuora mwoyo zvinogona kuva zvakaoma kugadzirisa uye kazhinji zvinoda kuti vamwe varohwe kana kuti vashayike kuti vawane rubatsiro rwakakodzera rwerapa. Asi nekufamba kwenguva, vanhu vazhinji vanogona kuwana hutano hwakanaka hwezviratidzo zvavo nehuwandu hwemigumisiro.
Kuzviuraya Kuraira Zviratidzo
Mukumwe kukurukurirana pamusoro pekuora mwoyo, zvingava zvakashata kuti usataure kuzviuraya. Zvinosuruvarisa, kuzviedza kuzviuraya uye kubudirira kuzviuraya zvakanyanya kwazvo kune avo vane kuora mwoyo. Kana iwe kana munhu waunoda akatambura nekuora mwoyo, bipolar disorder, kana chirwere chipi nechipi chepfungwa, ongorora zviratidzo zvekuzviuraya . Uye uzive kuti kune rubatsiro kunze uko maawa makumi maviri nemazuva, mazuva manomwe pavhiki. Dana zita reNational Suicide Prevention Hotline kana uine zvinetso zvachose.
Sources:
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