Fungidzira kuve nekukwanisa kuwana chirwere chinogona kukupikisa mukurwisa nicotine . Mushure mokunge mutsva wezvinyorwa zvinokurudzira muviri wako kuti uite zvirwere zvinokonzera nicotine, chirwere chacho chinogona kupa mishonga isiri yodhakwa.
Kunyange zvazvo zvingaita sokuti hazvina kukwana, chirwere chakadai chiri pasi pekugadzirwa. Pakutanga kuongororwa nevatsvakurudzi veNabi Biopharmaceuticals pasi pezita raNicVax, Nabi akapiwa $ 10 mamiriyoni muna 2009 neNational Institute on Drug Abuse, chikamu cheNational Institutes of Health kuti chienderere mberi nekutanga kwechikamu chechitatu chechirwere.
Zvinosuruvarisa, muna July wegore ra2011, vakataura migumisiro yakaodza mwoyo, vachiti chikwata chekutanga chechitatu chakatadza, uye 30% chete yevarwere vachiona chero mhinduro. MunaNovember wegore rimwe chete, ivo vakazivisa chikwata chechipiri chechitatu chakanga chakakundikana, uye chirwere ichi chisina kuita nani pane placebo.
Mishonga Inoshanda Sei?
Kana munhu akawana mushonga, pfuti yacho ine zvimwe zvehutachiona hunotarirwa kana mabhakitiriya mune imwe nzvimbo isina simba kana yakafa. Kana imwe yakaziviswa mumuviri, maitiro ezvirwere zvezvirwere anoziva uye anogadzira zvirwere zvinoparadza kana kudzivisa zvirwere zvinopinda. Nenzira iyi, muviri wakagadzirirwa kurwisana nehutachiona hwehupenyu kana mabhakitiriya, kana zvichiitika.
Nzira yekuti Nicotine Vaccine yakagadzirirwa sei kushanda
Maikorolekemu mashoma uye anofamba nyore nyore kuburikidza neropa reuropi, apo vanosungira nicotine receptors iyo inobatsira nzira yekupa muuropi, ichiwedzera dopamine . Dopamine inonzi neurotransmitter iyo inokonzera manzwiro emufaro, hukama hwakanaka, uye kuvimba.
Iyi ndiyo nzira inofungidzirwa kuti ndiyo inokonzera kusvuta mumuviri.
Iyo nicotin vaccine inodzidzisa muviri kurwisa nicotine. Inoita izvi nekushandisa nicotine haptens mu serum. Mafaro ndiwo masikorosi anokurudzira kugadzirwa kwehutachiona uye kukwezva kana akabatanidzwa nehukuru hwepuroteni mamolekemu.
Kana chirwere chinopinda muropa nerupfu muruoko, muviri unopinda kune haptens nekugadzira zvirwere zvinokonzera nicotine. Izvozvo zvinorwisana "zvinobata" nicotine molecules kuburikidza nazvo. Nemhaka yekuti zvirwere (uye zvakabatanidzwa nicotine molecules) zvakakura kwazvo kuti dzisakanganise ropa / kamuviri wepfungwa, nicotine haikwanisi kuenda kune uropi iyo inogona kukonzera dopamine kusunungurwa.
Pasina dopamine, vanosvuta havafariri kusvuta uye kushamwaridzana nekupindwa mumuviri kunoputsika.
Nhasi Indotini Vaccine Research
Vatsvakurudzi veThe Scripps Research Institute (TSRI) vari kushanda mukugadzira chirwere chinonyanyisa chinonzi nicotine uye vakaona zviratidzo zvinokurudzira kuti vari munzira yakarurama.
Maererano naProfesa weKemistri muTTRI, Kim Janda, kune maitiro maviri eicotine iyo mifananidzo yemifananidzo, "kuruboshwe" uye "right-handed" molecules, kana uchida. Iyo nikotine mufodya inenge yakazara zvachose necheboshwe-dzakasiyana siyana. Mushonga weNicVax wakanga wakagadzirwa nekusanganiswa kwezvose zvakasara uye kurudyi-nicotine haptens uye yakanga isiri mushonga unobatsira.
Vatsvakurudzi ve TSRI vakasika maitiro matatu emishonga: 50/50 kusanganiswa kwemaikotini maviri, uye yakachena yakachena uye yakachena yakasara-gwapa zvirwere.
Muchiedzwa chebhroatori pamakonzo, vakaona kuti 50/50 kusanganiswa kwaingova 60 muzana chete yakashanda seyakachena yakasara.
"Izvi zvinoratidza kuti zvirwere zvinotevera zvichafanirwa nechokupedzisira," akadaro Jonathan Lockner mukudhinda kwegore ra2015 kubva kuchikoro. Lockner ishamwari yekutsvakurudza muJanda lab.
Kutsvakurudza kuri kupfuurira asi kunotarisa kuvimbisa remangwana.
Nyokotini vachengeti, kana yakagamuchirwa, ichave yakakosha kune zvimwe zvakasiyana-siyana zvekurega zviwanikwa zviripo nhasi. Nehupenyu hwehupenyu huri kurasikirwa nehutachiona hunoratidzira fodya maminitsi masere ose pane imwe nzvimbo panyika, vanosvuta vanoita sarudzo dzakawanda sezvinobvira kuti vabatsire kurova nicotine kusvuta vasati vavarova.
Kunobva:
The Scripps Research Institute. TSRI Scientists Purojekiti yeNicotine Yakagadzirisa Iyo Inopa Mhinduro Yakasimba Yakasimba. http://www.scripps.edu/news/press/2015/20150112janda.html. Yakasvika muna February 2016.
Nabi Biopharmaceuticals. Nabi Biopharmaceuticals Inotanga Pivotal Phase III Chidzidzo cheNicVAX seZvabatsiro Kuputa Kusagadzikana uye Kubvisa Kwenguva refu http://phx.corporate-ir.net/phoenix.zhtml?c=100445&p=irol-newsArticle&ID=1350155&highlight=. Yakasvika muna February 2016.