Dambudziko reInoro Rinogona Kudziviswa, Masayendisiti Anoti
Masayendisiti ave achiedza kwemakore akawanda kuti aone kuti doro rinokanganisa sei uropi mune tariro yekuvandudza mishonga inobatsira vanhu vari kuedza kurega kunwa.
Kana tikadzidza kuti makemikari anochinja anoitika sei muuropi semugumisiro wekudhakwa, zvino chirevo ndechekuti, tinogona kukudziridza vanopikisa izvo zvicharambidza migumisiro yekudhakwa, zvichiita kuti zvisazonakidza kunwa.
Vamwe vatsvakurudzi vanotenda kuti vakawana mafaira ekugadzirisa zvinokonzerwa newaini uye zvinokurudzira uye, kana pavharwa, inogona kumisa doro kuitika pauropi.
Nzvimbo Dzakanaka dzeBongo
Chinangwa chekutsvakurudza uku chave chiri pamamygdala, chikamu chematunhu munzvimbo dzinofadza dzeuropi. Kwemakore, vatsvakurudzi vakaziva kuti doro rinounza zvizhinji zvekuita kwayo kunodhaka nekuita imwe yeurotransmitter imwe inonzi gamma-amino butyric acid (GABA).
GABA ndiyo inokonzera hutano hwehutano hweuropi uye inoparadzirwa zvikuru muuropi. Neurons anoshandisa GABA kuti iite zvakanaka kuisa chiratidzo mukati mehutano hwemagetsi.
Ongororo dzinoverengeka dzedambudziko rekushandisa doro dzakaratidza kuti basa reGABA rinoderera munzvimbo inofadza yeuropi munguva yekudhakwa kunwa doro uye munguva inopera nguva yekurega shure mushure mekunge munhu anonwa kunwa - iyo nguva apo munhu ane doro ari kunyanya kunetseka kudzoka zvakare.
Vatsvakurudzi vanodavira kuti kuchinja kwegasa reGABA muAmygdala panguva yekutanga-nguva yekurega nguva ndiyo chikonzero chikuru chekudzokera zvakare kune vanhu vari kurapwa nekudhakwa.
CRF Peptide Yakabatana neAdha Inonzi Dependence
Mukuedza kuziva zvakananga kuti doro rinokanganisa sei GABA receptor basa, masayendisiti paThe Scripps Research Institute akawana kuti kana zvirwere zvikabatwa nedoro zvinosunungura brain peptide inonzi corticotropin-releasing factor (CRF).
Peptide iketani shoma reamino acids.
CRF ndiyo peptide yakajairika muuropi iyo inozivikanwa nokuda kwekushanda mumamygdala tsitsi nemhinduro dzekuita kune zvinonetsa. Yakagara yakabatanidzwa nehuropiti yekupindura kumanikidziro, kushushikana, uye kuora mwoyo. CRF levels inowedzera muuropi kana doro rapera.
Migumisiro Doro Inogona Kudziviswa
Zvisinei, zvidzidzo zvakawana kuti zvikwata zveRFF zvinowedzerawo apo mhuka dzinodzinga doro, izvo zvinogona kutsanangura nei chidhakwa chiri mukutadza kudzokazve kana vachiedza kugara vasina nguva kwenguva refu.
Zvidzidzo zvezvipfuwo zvakawana kuti apo CRF receior inobviswa nekotokisi yegeneti, zvinoitika zvewaini neRFF paGABA neurotransmission yakarasika.
Muchidzidzo cheMagwaro, Neuropharmacology Purofesa George Siggins nevamwe vaaishanda navo vakawana kuti pavakashandisa mushori weRFF, doro rakanga risingachagoni kuita.
"Hazvina kungoita kuti vadzivisi vadzivise kukanganisa kweRFF mukusimudzira GABA kutapurirana, zvakare kwakadzivisa kukanganisa doro," anodaro Siggins. "Mhinduro yacho yakange yaenda zvachose - doro rakanga risati raita chero chinhu."
Rimwe Receptor Inobatanidzwa?
Siggins inofunga kuti kuwedzera mishonga inodzivirira migumisiro yeRFF, uye naizvozvo doro, panzvimbo dzinofadza dzeuropi, inogona kubatsira vakadhakwa vari kuedza kurega kunwa kuti vasadzoke zvakare.
Zvisinei, chidzidzo chekupedzisira pa VA Medical Center muDurham, North Carolina yakawana kuti CRF uye kappa-opioid receptor (KOR) zvose zvakabatanidzwa mukuzvibata zvine chokuita nekuzvidya mwoyo uye kuzvidzora kwemishonga.
Vakuru veNorth Carolina vatsvakurudza vakaratidza kuti chero ipi zvayo inogona kushandisa mishonga inofanirwa nehutsika uye hutachiona hunogona kudikanwa kusanganisira zvose zvirongwa zveRFF neKOR.
Sources:
Kang-Park, M, uye al. "Kutaurirana kweRFF uye Kappa Opioid Systems paGABAergic Neurotransmission muMouse Central Amygdala." Journal of Pharmacology and Experimental Therapeutics Nyamavhuvhu 2015
Siggins, GR, et al. "Ethanol Augments GABAergic Transmission muCentral Amygdala neRRF1 Receptors." Sayenzi March 5, 2004