Chirwere chemishonga inonzi inozivikanwa kuti inopindirana nemimwe mishonga uye zvimwe zvokudya, asi inogonawo kugadziriswa nekuputa-uye kusvuta kusvuta.
Mamwe Mishonga Inonyorwa Mishonga Inopesvedzerwa neSigarette Smoke
Zvokudya zvatinodya zvakaputsika (metabolized) muzvinhu zvinovaka muviri izvo miviri yedu inogona kushandisa. Izvi zvinotanga nemakemikari, izvo zvinoita sechigadziriso chekugadzira chirwere.
Kune marudzi akawanda emakemikari. Mamwe acho anobatsira kuputsa mapuroteni, mamwe anobata ma carbohydrate, uye vamwe pane mafuta.
Nenzira imwecheteyo, kune ma enzymes anochera mishonga yemishonga. Chimwe chezvinokonzera mishonga iyi, CYP1A2, inokanganiswa nemamwe makemikari muutsi hwefodya. Izvozvo zvinokonzera, zvinonzi PAHs (polycyclic anonhuhwanda hydrocarbons) dzinozivikanwa kuti ndiyo imwe yemakemikari anonyanya kunyanya muutsi hwefodya .
Apo PAHs inosangana neCYP1A2 iyo enzyme inowedzera kushanda. Izvi zvinokonzera mishonga inoputsika neCYP1A2 kuti ive yakagadziriswa zvakanyanya nokukurumidza kupfuura iyo inofanira kuva. Somugumisiro, vanosvuta vanowanzoda chiremba chakakwirira pane zvingawanzopiwa.
Apo kusvuta kunomira pakarepo, zvakadai sokupinda muchipatara uko kusvuta hakubvumirwi kana kuti kurega kutonhora kunotonhora, CYP1A2 basa rinoderera uye mukana mukuru unogona kukurumidza kuwandisa. Mukana wekusava nemigumisiro yakaipa yemishonga inowedzera nokukurumidza zvakare.
Zvakakosha kuti mishonga iongororwe uye zvichida kugadziriswa nekugadza chiremba kana munhu achirega kusvuta.
Zvirongwa Zvinodhaka Zvinoputirwa neYP1A2
Sezvaunogona kuona kubva pane urongwa, mishonga yakawanda yakasiyana-siyana inoshandiswa neYP1A2. Mamwe acho haazokonzeri kupindira kwakaitika mushure mekupera kusvuta, asi zvimwe zvinogona kukonzera migumisiro yakakomba kana chirwere chisina kuchinjwa kana kugadziriswa kana munhu arega kusvuta.
Usanonoka kugovera yako kurega kusvuta fodya neboka rako rehutano hwehutano kuitira kuti vakwanise kuramba vakatarira chero kuchinja chero kupi zvingangodaro.
- Alosetron (Lotronex): antidiarrheal inoshandiswa kurapa chirwere chinokanganisa chirwere
- Clozapine: zvinodhaka zvinoshandiswa kurapa schizophrenia
- Flutamide (Eulexin): hormone-based chemotherapy mishonga
- Fluvoxamine (Luvox): inoshandiswa kurapa maitiro asina kukodzera kana kumanikidzira
- Frovatriptan (Frova): inoshandiswa kugadzira migraine misoro
- Haloperidol (Haldol): anobata schizophrenia, psychosis yakajeka, uye inoshandiswa kumashoko ezwi nemashoko e Tourette's syndrome
- Imipramine (Tofranil): yaishandiswa kurapa kuora mwoyo
- Melatonin: pamusoro pemubhadharo wokuwedzera unoshandiswa kurara
- Mexiletine (Mexitil): antiarrhythmic inoshandiswa kurapa kusagadzikana kwepfungwa
- Mirtazapine (Remeron): anodzvinyirira anoshandiswa kurapa kuora mwoyo.
- Olanzapine (Zyprexa): yakashandiswa schizophrenia, bipolar disorder
- Propanolol (Inderal): yaishandiswa kuporesa kudengenyeka, angina (kurwadziwa kwepfupa), kukwirira kweropa, kukanganiswa kwemwoyo, uye mamwe mwoyo kana mamiriro ezvinhu epakati. Yakashandiswawo kubata mushonga wemusoro
- Ramelteon (Rozerem): sedative inoshandiswa pakurara
- Rasagiline (Azilect): MAOI uye antidipressant inogona kushandiswa kurapa chirwere chePalinson
- Ropinirole (Requip): dopamine kukurudzira iyo inogona kushandiswa kurapa chirwere chePasinson uye chirwere chemakumbo asingagadzi
- Tacrine (Cognex): yakashandiswa kurapa chirwere cheAlzheimer
- Theophylline: kwenguva yakareba asthma kudzora mishonga
- Tizanidine (Zanaflex): tsvina yakasununguka inoshandiswa kurapa maronda emasumbu
- Triamterene (Dyrenium): diuretic inoshandiswa kugadzirisa kuchengetedza uye kuwedzerwa kweropa
- Zolmitriptan (Zomig): triptan inoshandiswa kupora migraine misoro
Caffeine Inobatanidzwawo neYP1A2
Vazhinji vekare vari kusvuta vachakuudza kuti kofi yakanga ine simba rakanyanya kwavari shure kwekurega kusvuta. Inowanzoitwa mukombe kana maviri mangwanani, yakasiyira jitteri uye inotyisa.
Vaizonyangadza kusvika pakushayikwa kwekicinine , uye izvozvo zvinotamba basa, asi zvichida zvaive zvine zvakawanda zvine chokuita neYP1A2.
Vakasvuta vanoshambadzira caffeine panguva inenge kaviri muyero wevasati vasvuta. Hazvishamisi kuti kunwa doro rinowanzoitwa kafi kana zvimwe zvinwiwa zve caffeinated zvinobva zvisinganzwisisiki mushure mekusvuta kusvuta. Kana iwe uchangobva kurega, unogona kuedza kuderedza caffeine yako kushandiswa nehafu uye kuona kuti unonzwa sei. Iwe unogona kuderedza kana kuwedzera kubva pane izvozvo.
Nicotine uye Prescription Mishonga
Nicotine mufodya uye muicotine kushandiswa kurapwa kunogona kuitawo kuti muviri unokwanisa kupindura sei mishonga.
Nicotine inotakura midziyo yeropa uye inogona kudzivisa kuvhara kwe insulini shots.
Nicotine inokurudzira iyo inomutsa kuwedzera kwemwoyo uye kuwedzerwa kweropa. Izvo zvinogona kuita kuti kuderedzwa kwemishonga inoshandiswa kubata zvakafanana. Inobatanidzwawo nekuderedza sedation kubva ku benzodiazepines (runyararo) uye kununurwa kunorwadza kubva kune dzimwe opioid.
Rongedza Kusarudzwa Nechiremba Wako
Kana iwe ukatora mishonga yemishonga uye wakamira kusvuta (kana iwe unoronga ku), tarisa nechiremba wako kuti uongorore kuti ingangodaro inokanganiswa sei nekurega kusvuta.
Mashoko akanaka ndeokuti kubvisa kusvuta kuchavandudza utano hwako uye hutano. Iwe unogona kutowana kuti mamwe mishonga inogona kubviswa kana muviri wako uchidzoka kubva kune nicotine .
Kana wakagadzirira kusiya, shandisa izvi kurega kusvuta midziyo sekutanga. Hapana nguva yakafanana neyiyo kutanga kutanga basa pakuita kuti kurota kwako kuve kwechokwadi.
Sources:
Prescriber Australia. Kusvuta uye Kurapa Zvinodhaka. https://www.nps.org.au/australian-prescriber/articles/smoking-and-drug-interactions.
Pharmacy Times. Ziva Kuziva Enzyme: CYP1A2. http://www.pharmacytimes.com/publications/issue/2007/2007-11/2007-11-8279.