Muedzo Unogona Kuona Kukanganisa Kunwa Doro, Kudzokorora
Vashandi vehutano avo vane hanya kuti varwere vavo vangave vari kunwa doro pane zvinokuvadza vane kuongorora ropa vanogona kushandisa kuti vaone kana vari kunyanya kunwa doro.
Kuongorora kwemahydrohydrate-deficient transfrin (CDT) yakagamuchirwa muna 2001 ne FDA semuedzo wewaini wewaini. Inogona kushandiswa kuona kana mumwe munhu akadhakwa kana kuti anonwa zuva nezuva (mana kana zvimwe zvinwiwa pazuva).
Inogona kushandiswa kutarisa kana doro rinodzokorora zvakare.
Zvikonzero Zvokurapa Hazvifaniri Kunwa
Kune mamiriro ezvinhu akawanda ekurapa umo murwere haafaniri kudya doro, kana kusadya doro rakawandisa doro. Vanhu vane chirwere cheshuga kana kuwedzerwa kweropa, somuenzaniso, havafaniri kunwa zvakanyanya, uye havafanirwe munhu ane Hepatitis C kana chirwere cheropa.
Varwere vari kutora mimwe mishonga havafaniri kunwa nekuda kwedambudziko rekutarisana nemishonga uye doro . Vanhu vari kurapwa nemarwadzo ane opioid painkillers kana avo vari kutora sedatives kana kuti zvigaro zvekurara havafaniri kunwa doro zvakanyanya nekuda kwekuda kwehutano hwavo hwemagetsi huvhara.
Kuzvipira Kuzvipira Kusingaitiki
Nenzira, vanachiremba nevamwe vashandi vehutano vakashandisa nguva shomanana yekuongorora kuongorora doro kuti vaone kana mukana wevarwere vavo doro rekushandisa. Dambudziko neavo kuongorora kuongororwa nemigumisiro yavo inobva kune murwere ari akatendeseka pamusoro pehuwandu hwavanonwa.
Varwere vasina dambudziko rezvinodhaka zvinogona kunyanya kunyanya kuzvitaurira kuti ivo vanoshandiswa sei. Asi avo vane dambudziko vanowanzoita kuti vasanyanya kunwa doro ravo. Kuwedzerwa dambudziko racho, kunyanya murwere acharamba doro rinodhaka.
Saka, izvo zviitiko zvishomanana zvekuongorora zvinyorwa zvinotarisirwa muhutano hwekuchengetedza hutano hazvizoiti kuongorora kwakarurama.
Chirwere cheCDT chinopa muchengeti wehutano chimwe chinhu kana vachifungidzira murwere angave achishandisa doro zvisina kufanira.
Chiyero cheCDT chii?
Transferrin inhengo muropa iro rinotakura dare kumapfupa emapfupa, chiropa, uye spleen. Apo mumwe munhu anonwa zvakanyanya, inowedzera mamwe marudzi e transfratory ayo asina kukwana-carbohydrate. Apo iyo-carrihydrate isingakwanisi transfrin yanda kuwedzera, inogona kuyerwa muropa uye naizvozvo ndiyo inoshandiswa kudhakwa zvinodhaka .
Muedzo weCTT unoshanda sei?
Vanhu vasingadi kunwa, kana kunwa zvakaenzana, vachava necheputiki yehydrohydrate-yakakwana kutengesa maitiro muropa ravo, zvimwe zvidzidzo zvinoshandisa kudonhedzwa kunopfuura pasi pe1,7 muzana. Asi, vanhu vanonwa zvimwi kana kupfuura zvinwiwa pazuva, mazuva masere mashanu pavhiki kwevhiki mbiri vasati vaedzwa vachave neCDT pane zvikamu zvakakura zvikuru.
Kune varwere vanonwa bhodhoro rewaini, madoro mashanu, kana hafu yepiti ye whiskey pazuva, kuongorora kweCDT kwakanyatsokwana pakuona iyo yezinga rekumwa doro .
Zvakawanda nenzira imwechete iyo kuongorora kweA1C kunogona kuona mazinga emushuga muropa kwemazuva makumi mapfumbamwe, chirwere cheCDT chinogona kuona doro rinodhaka kwenguva yakareba.
Kana munhu wacho akarega kunwa, maCDT achaderera, asi kana achatanga kunwazve, maitiro acho achawedzera zvakare.
Nhema Nhamba
Kutanga, havasi vose vane CDT senzwi. Muchikamu chiduku chehuwandu hwevanhu, doro rinodhaka rinoshandiswa haritauri huwandu hwehydrohydrate-yakakosha transferrin. Nokudaro, vatapi vehutano vanofunga kuti kunwa kwakanyanya muvarwere vavo vanokurudzirwa kushandisa imwe doro inonzi biomarker test zvakare.
Kune zvimwe zvinhu zvinokonzerwa nehupenyu zvinogona kuwedzera zvenhema maCDT, zvakadai semasikirini akasiyana-siyana, mahomoni evanhukadzi, mashizha ematare, pasi mashoma mashizha, catabolic states, chronic mapirmaria chirwere, uye kuguma-gadziriro yechipwere chechiropa.
Mavambo ekutanga eCDT aizodzoka maonero emanyepo nekuda kwezvikonzero zvataurwa pamusoro apa, asi zvino maedzo matsva anogona kuona zviratidzo zvinokonzerwa nemararamiro anogona kukonzera zviratidzo zvenhema nezvisina kunaka, uyewo maitiro anokonzerwa nechirwere chechiropa chakaenderana nekunwa doro.
Kuunganidza Mamwe Mashoko
Pakave nekuongororwa kwakawanda kunoitwa kubudirira kwekushandisa chirongwa cheCDT kuti uone kunwisa kwakanyanya kune varwere, uye kunyange zvazvo zvidzidzo izvi zvichiwana kuti kuedza ndiko kwakarurama kwazvo, hazvina maturo.
Vatsvakurudzi vanoratidza kuti kana chirwere cheCDT cherwere chichiratidza kunwa kwakashata, vatapi vezvoutano vanoshandisa dzimwe nzira kuti vabatsire kusimbisa zvabuda-kusanganisira kushandiswa kwemibvunzo, yeGGT (gamma-glutamyl transpeptidase) test, kana chirongwa cheGeG (ethyl glucuronide) ( inoona kunwa doro mumaawa 24-72 apfuura).
Nei Kutariswa kweCDT Kunokosha?
Chimwe chezviongorori zvekutsvakurudza zvakashandisa kuongororwa kweCDT pakati pevarwere vane chirwere cheshuga nehuwandu hwehutachiwana vakawana kuti kune 799 varwere vakadzidza, 9 muzana yevanhu vane chirwere cheshuga uye 15 muzana yevaya vane ropa rekumanikidza vari kunwa pane zvinokuvadza.
Kana zvikamu izvi zvikaita munyika yose, zvinogona kureva kuti 1.35 mamiriyoni evanhu vane chirwere cheshuga uye 7.5 mamiriyoni ehutachiona hwehutano vari kunwa pamazinga ari kuisa hutano hwavo pangozi.
Nokudaro, vanotsvakurudza vanoratidza kuti mari yehutano inogona kuderedzwa zvikuru kana vashandi vezvoutano vakashandisa kuongororwa kweCDT kuti vaone varwere vane chirwere cheshuga, huwandu hwehutano, uye mamwe mamiriro ezvinhu ari kunwa zvakanyanya.
Inobatsira Mukuona Kuchengeta
Mukuwedzera pakuona kunwisa kwakanyanya kune varwere vane doro-yakaoma, mamiriro ekuongorora maCDT anogona kushandiswa munharaunda yekushandisa zvinodhaka kuti vaone kuregerera uye kudzokera zvakare.
Vamwe vanofunga nezvepfungwa uye vezvepfungwa vanobata newaini zvinoshandisa chirwere cheCDT kuti vawane nhamba yepamusoro apo pavanotanga kusangana nemurwere. Mumavhiki nemwedzi inotevera, vanogona kushandisa sarudzo dzeCCDT mune ramangwana kuti vaone kana munhu wacho akasara kana kuti akadzoka pachivande.
Maererano nevatsvakurudzi, chirongwa cheCDT ndicho chete chinodhaka chinodhaka chinonzwisisika kuti chione kuderedza kudha doro kana kushanduka zvakare.
Sources
- Bianchi, V. et al. "Kufananidza pakati peSerum carbon-deficient transferrin nemvere ethyl glucuronide pakuona kusingaperi doro kushandiswa muitiro." Doro uye Doro May 2015.
- DeGiovanni, N, et al. "Kubatsira kwevanhu vanodhakwa zvinodhakwa mumusoro uye sarum-carbohydrate-yakakosha transferrin: nhau yenyaya." Kuongorora Zvinodhaka uye Kuongororwa December 2014
- University Medical South Carolina. "Kuwedzerwa Kunwa Doro Doro - Dhaifidhi Yakakosha yeChydhydrate (% CDT) uye Urine Ethylglucuronide (EtG) Kuedzwa." Institute of Psychiatry Akawana June 2015
- US National Library of Medicine. "Gamma-glutamyl transpeptidase." Medical Encyclopedia