Wakambofunga nezvekuedza Chantix kuti urege kusvuta here? Chantix (varenicline tartrate) isiri mishonga yemishonga inenge isina nicotine yakagadzirwa naPfizer, Inc. kunyanya kubatsira vanhu kurega kusvuta.
Sei Chantix Inoshanda
Chantix inoshanda pamatanho maviri. Chokutanga, iyo inobatanidza zvikamu muhuropi inozivikanwa se nicotinic acetylcholine receptors iyo inokanganiswa neicotine. Izvi zvinoita kuti vatsva vatsva vatsva vaone nicotine-sezvinoitika uye inoderedza zviratidzo zvekuicotine kubvisa . Chechipiri, Chantix ine simba rakasiyana-siyana rekumisa nicotine kubva pakubatanidza kune iyo nicotine receptors kana iwe utsi uchiri kushandisa.
Iyo Nicotine Inobata Sei Bongo Chemistry
Nicotine inokupa inenge inokurumidza "kukanganisa" kwekupupurika iyo inokonzerwa nekuchinja nokukurumidza kemikemikari, uye inotanga mukati memaminitsi manomwe ekutanga kunya fodya.
Apo nicotine inopinda muuropi, inoita ne nicotinic acetylcholine receptors. Iyo nicotine molecule inofanana zvakakosha neurotransmitter inonzi acetylcholine, iyo inokanganisa mabasa akawanda emumuviri, kusanganisira kufema, moyo wepamusoro, kudzidza, nekuyeuka. Acetylcholine inobatawo dzimwe nyanzvi dzemhepo dzinokanganisa kudya, manzwiro, nekuyeuka.
Muuropi, nicotine inosungirirwa kune nerve cell receptor nzvimbo munzvimbo dzinenge apo acetylcholine ingadai, kuumba zvakafanana. Kana ikanyatsobatanidzwa, kusunungurwa kwe dopamine kunokonzerwa.
Dopamine inonzi neurotransmitter inofungidzirwa kuti inofanirwa kusimbisa kushamwaridzana nemafaro evanhu vanofara nekuputa.
Icho chiitiko chemakemikari iyo inofungidzirwa kuti inokonzera kukanganisa. Zvimwe zvinodhaka zvinodhaka zvakadai secocaine, amphetamines, uye opioids zvinoitawo kuti kusunungurwa kwedopamine.
Izvozvo zvinokonzerwa neikotine zvinopera mukati memaminitsi, saka vanhu vanoramba vachizvidzivirira kakawanda mukati mezuva kuti varambe vachifadza zvinokonzerwa neicotine uye kudzivirira kudzima zviratidzo.
Sei Chantix Inobata Nicotinic Receptors
Apo Chantix inowanikwa muuropi, inotarisa imwe rudzi rune nicotinic receptor inonzi alpha4beta2 nicotinic receptors . Iyo inokonzerwa nemamato aya, zvichikonzera kusunungurwa kwe dopamine nenzira imwechete iyo nicotine yaizoita, zvisinei kwete zvakanyanya. Kune vakwegura kare, mhedzisiro yakaenzana nechepakati kusvika kumazinga mashoma eicotine anogara kusvikira mishonga inopera, iyo maawa akawanda.
Nenzira iyi, Chantix inobatsira kuderedza zviratidzo zvekuicotine kurega izvo vanhu vanoona pavanorega kusvuta.
Bhonasi yakawedzerwa pano ndeyokuti kana Chantix yakanamirwa panzvimbo idzi dzinogamuchirwa, nicotine haigone kuita zvakafanana. Saka, kana ukasarudza kusvuta fodya paunenge uine Chantix mumutambo wako, fodya haichazoiti "inonzwa zvakanaka" kukurudzira dopamine. Kusvuta kuchava ruzivo rwakanyarara / rwakashata uye kurega kunofunga kuti zviri nyore kubudirira.
Kutsvakurudza pamusoro Kushanda kweCantix
Zvidzidzo zvitanhatu zvemakiriniki zvinosanganisira 3659 zvisingaperi zvekusvuta fodya zvakashandiswa senheyo yekubudirira kweCantix sechirapa yekurega kusvuta, maererano neU.S. Food and Drug Administration (FDA). Miedzo yakaratidza kuti Chantix yaive yakakosha kupfuura yepa placebo kubatsira vanhu kurega kusvuta. Mune miviri miedzo mitanhatu, vanhu vanoshandisa Chantix therapy (22 muzana) vakabudirira zvikuru pakurega kusvuta kune avo vanoshandisa Zyban (bupropion hydrochloride) (16 muzana) sokurega kurega kusvuta. Kune avo vanotora placebo, kuzvidzora pane rimwe gore chiratidzo chaiva ne8 muzana.
Mune imwe nguva ichangobva kuongorora, vatsvakurudzi vakatarisa vanhu 1086 vakasiya kusvuta vachishandisa imwe yenzira nhatu dzinotevera: Chantix , nicotine patch , kana chigamba uye nicotine lozenges yakashandiswa pamwe chete.
Zvigumisiro zvakaratidza kuti vatatu vakasiya nzira dzaive dzakafanana mukubudirira kwehuwandu pamwedzi mitanhatu uye gore rimwechete. Kwemwedzi mitanhatu, 23 muzana yevatori vechikamu vaishandisa chigamba vakanga vachiri kusvuta-vakasununguka, vachienzaniswa ne24 muzana yevaya vanoshandisa Chantix, uye 27 muzana yevanhu vakashandisa kusanganiswa kwechigamba uye lozenges. Pamwe gore, kubudirira kwepakati kwaive 21 muzana yechikwata, 19 muzana yeCantix, uye 20 muzana yemusanganiswa.
Imwe tsvakurudzo yakaratidza zvakare kuti kusanganiswa kweCantix uye nicotine patch kwaive nesimba kupfuura kushandisa Chantix chete, kunyange zvidzidzo zvakawanda zvinodiwa.
Kunyange Kubudirira Kudiki Ndikukunda
Kunyange zvazvo kubudirira kwehutano kungasaita sekunakidza, ramba uchifunga mupfungwa yakawanda yevanhu vanodhakwa neicotine uye vanofa nekuda kwayo nhasi. Munyika yose, zvirwere zvine chokuita nekuputa zvinokonzera kufa kwemamiriyoni matanhatu gore negore .
Isa imwe nzira, fodya inotaura hupenyu hwomunhu kwemaminitsi mashanu mashanu kune imwe nzvimbo munyika. Chirwere chinogona kubatsira vanenge makumi maviri nevashanu kubva pavanhu 100 vanochishandisa kusasiya fodya zvakakodzera kufungisisa.
Zvakakoshawo kurega kusarudza rubatsiro runowanikwa kuvanhu vanoda kurega kusvuta nokuti izvo zvinoshanda kune imwe zvingasashanda kune munhu anotevera. Chisarudzo chikuru chinokwana mukana mukuru wokubudirira, pakupedzisira.
Chantix Safety
Mumakore kubva Chantix yakavapo, zvimwe zvinetso zvakakomba zveutano zvakabatanidzwa nekushandiswa kwayo zvakaratidzwa. Chantix inorayirwa mishonga nokuti, sezvinenge iine mishonga ipi zvayo, zvinogona kuva nemigumisiro mikuru yezana shoma yevanhu.
Kana iwe uchida kushandisa Chantix, taura chiremba wako kuti asarudze kana zvingava sarudzo yakanaka kwauri.
> Sources:
> Koegelenberg CF, Noor F, Bateman ED, et al. Kubudirira kweVarenicline Yakabatana neNicotine Replacement Therapy vs Varenicline Yega Yekusvuta Kuchema: A Randomized Clinical Trial. JAMA . July 2014; 312 (2): 155-61. doi: 10.1001 / jama.2014.7195.
> Baker TB, Piper ME, Stein JH, et al. T Mhinduro dzeNikotine Patch vs. Varenicline vs. Kusanganiswa kweNicotine Replacement Therapy paKutsvaga Kupedza pavhiki makumi maviri nemakumi manomwe: Randedzed Controled Trial. JAMA . 2016; 315 (4): 371-379. doi: 10.1001 / jama.2015.19284.
> Pfizer. About Chantix. Yakavandudzwa muna July 2017.
> US Food and Drug Administration (FDA). FDA Inobvumira Rino Mishonga Yekusvuta Kupedza. Yakabudiswa May 12, 2006.