Kutsvakurudza Kunoratidzei Nezvezvinhu Zvinokonzerwa Nezvinetso Zvinotyisa?
Parizvino, chinonyatsokonzera kushungurudzika kwepfungwa hachizivikanwi. Zvisinei, pane mazano akawanda anoita zvinhu zvakasiyana-siyana pakufunga paanoongorora zvinokonzera kukanganisa chirwere. Verenga mberi kuti udzidze zvakawanda pamusoro peshoko rezvinyorwa zvekutya chirwere.
Nyaya yeBiological The Panic Disorder
Serotonin , norepinephrine uye dopamine makemikari anoita sevanonzi neurotransmitters kana vatumwa muuropi .
Vanotumira mameseji pakati penzvimbo dzakasiyana dzeuropi uye vanofungidzirwa kuti vanokanganisa mafungiro evanhu uye kushungurudzika. Imwe nyanzvi yekutyisa dambudziko ndechokuti zviratidzo zvinokonzerwa nekusawirirana kweimwe kana zvimwe zvemakemikari.
Iyo inozivikanwa seyiyo inyanzvi yehupenyu yekutya kwepfungwa, iyi nheyo inotsvaga zvisikwa zvikonzero sechikonzero chehutano hwepfungwa. Kutsigirwa kweiyi pfungwa ndeyokuderedza kunetseka kwezvirwere zvirwere zvakawanda varwere vanowanikwa apo vanodzvinyirira, izvo zvinoshandura huropi chemakemikari, zvinotangwa. Mimwe mienzaniso ndeyi:
- Kusarudza serotonin reuptake inhibitors (SSRIs) (yakadai saPaulil (paroxetine), Prozac (fluoxetine), uye Zoloft (sertraline) inoshanda nekuwedzera nhare ye serotonin muuropi.
- Serotonin-norepinephrine reuptake inhibitors (SNRIs) (yakadai seEfficexor (venlafaxine) uye Cymbalta (duloxetine) inoshandisa yese serotonin uye norepinephrine.
- Tricyclic antidepressants (TCAs) (yakadai seAnafranil (clomipramine) neElavil (amitriptyline)) inoshandisa serotonin, norepinephrin uye zvishoma, dopamine.
- Monoamine oxidase inhibitors (MAOIs) (yakadai seNardil, Parnate) inodzivisawo kutya kuburikidza nekuchinja makemikari emakemikari.
Zvimwe Zvokutsigirwa zveBiological Theory
Kunze kwekutya kwekutyisa chirwere chekuchinja kwehupenyu hwehupenyu hunobudiswa nehutachiona hwehutachiona, kune humwe humwe uchapupu hwokuti kuchinja kwehupenyu hwehupenyu muuropi kunogona kutungamirira kune chinotyisa chirwere chinosanganisira GABA nemafungiro emagetsi.
Gamma-Aminobutyric Acid (GABA)
Inofungidzirwa kuti gamma-aminobutyric acid- GABA-isiri yemakemikari muuropi inogadzirisa kufunganya. GABA inobatsira kufara muuropi kuburikidza nekuderedza kuzvidzora nekudzivisa kushungurudzika. Kutsvakurudza kwakaratidza kuti GABA inogona kuita basa munhau dzakawanda dzehutano hwepfungwa dzinosanganisira kushushikana uye zvinetso zvepfungwa.
Mishonga yeAn anti-anxiety medication ( benzodiazepines ) yakadai saXanax (alprazolam), Ativan (lorazepam), kana Klonopin (clonazepam), inoshanda nokuti inotarisa GABA receptors muuropi. Iyi mishonga inosimudzira basa reGABA rinoita kuti rive nerunyararo uye runyararo.
Mune zvidzidzo zvakasiyana-siyana, GABA maonero evanhu vane chirwere chinotyisa chinenge chiri pasi kudarika kutonga zvisingatauri nhoroondo yekutya. Kutsvakurudza kwemazuva anotevera kujekesa zviri nani basa reGABA mukuvhiringidzika kwehutano hwepfungwa, zvichida, kunotungamirira kune nzira dzakanakisisa dzemishonga kune vanorwara.
Metabolic Theories uye Panic Disorder
Ongororo dzemagetsi dzinotarisa kuti muviri wemunhu unoita sei zvimwe zvinhu. Zvakawanda zvezviongorori izvi zvakaratidza kuti vanhu vane dambudziko rekushungurudzika vanonyanya kunetseka kune zvimwe zvinhu kunze kwevasiri ivo vanopisa. Kucherechedza kwakadaro kunotsigira zvakananga dzidziso yezvinyorwa, kuratidza kuti avo vane dambudziko rekutyora vangave vakaita sei maitiro akasiyana kune avo vasina mamiriro aya.
Semuenzaniso, kutya kwekutyisa kunogona kukonzerwa kune vanhu vane nhamo yekutya nekuvapa injection ye lactic acid, chinhu chinowanzobudiswa nemuviri panguva yechirwere chemuviri. Zvimwe zvidzidzo zvakaratidza mhepo yekufema nepamusoro ye carbon dioxide inogona kukonzera kutya kune avo vane chirwere. Caffeine, nicotine uye doro zvakabatanidzwawo sezvinoita zvinotyisa kune avo vane chirwere chinotyisa.
Izvi Zvose Zvinorevei?
Pasinei nezvinorehwa nekutsvakurudza kusvika panguva ino, hapana mabhuku anotsvakurudza anoshanda anogona kubatsira mukuongorora chirwere chinotyisa . Makemikari nhume muuropi uye zvirongwa zvemagetsi zvinonetsa uye zvinopindirana.
Zvichida kuti imwe neimwe yezvirevo izvi inonyanya kukoshesa mukuvandudzwa kwekutya chirwere. Ongororo inotevera inodiwa kuti iwedzere kuderedza uye kusunga pamwe zvikonzero zvinokonzerwa nekutya chirwere.
Nyanzvi dzakawanda zvino dzinobvumirana kuti kutya kwepfungwa kunokonzerwa nekubatanidzwa kwezvinhu. Kutsvakurudza kwakatsigirawo pfungwa dzinotora zvinhu zvakasiyana-siyana munyaya dzakadai semunhu wei genetic uye zvakatipoteredza. Vanotsvakurudza vanoramba vachitsvaka zvikonzero zvinokonzera utano hwepfungwa, sekutya chirwere, sezvo izvi zvinogona kubatsira mukuongorora uye kusarudza nzira dzakanakisisa dzokurapa .
Paanenge achidzidza kuti nzira dzehupenyu hwehupenyu dzinogona kuita sei kutyisa chirwere hachibatsiri zvikuru mukuita kuti chirwere chekutyisa chinetseke, ruzivo urwu runogona kubatsira zvikuru kune avo vanozeza kutora mishonga yekuvandudza zviratidzo zvavo. Izvi ndezvechokwadi kune mamwe mamiriro ezvinhu ehutano hwepfungwa zvakare. Pakave nekunyadzisa pamusoro pehutano hwepfungwa, nemafungiro ari kuenderera mberi kuti munhu anofanira kukwanisa kukunda mamiriro ezvinhu akadai sekutyisa dambudziko pavari. Tichitarisa chatinenge tichidzidza pamusoro pezvinyorwa zvehupenyu uye hwemagetsi ekunyangadza kwepfungwa, iyi mafungiro akafanana nekutaura kuti mumwe munhu anofanira kupfurikidza nehuwandu hwemagetsi nekuve nemaonero akanaka chete.
Sources:
Goossens, L., Leibold, N., Peeters, R. et al. Brainstem Response to Hypercapnia: Chiratidzo Chikurudzira Kuongorora muPathophysiology ye Panic Disorder. Journal of Psychopharmacology . 2014. 28 (5): 449-56.
Schur, R., Draisma, L., Wijnen, J. et al. Ubongo GABA Nhamba Dzose Pfungwa Dzepfungwa: Kuongorora Zvinyorwa Zvesangano uye Meta-Kuongororwa kwe (1) H-MRS Studies. Bhuku reBurin Mapping . 2016. 37 (9): 3337-52.
Zangrossi, H., uye F. Graeff. Serotonin Mukuzvidya Mwoyo uye Kutyisa: Mipiro yeAkakwirira T-Maze. Neuroscience uye Biobehavioral Reviews . 2014. 46 Pt 3: 397-406.